Androgen Deficiency in Heart Failure

Güder, Gülmisal; Allolio, Bruno; Angermann, Christiane E.; Störk, Stefan

doi:10.1007/s11897-011-0053-9

Cited by 9 publications

(3 citation statements)

References 60 publications

(79 reference statements)

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“…The certain concentration of blood testosterone can attenuate the myocardial ischemia-reperfusion injury, fibrosis, apoptosis or necrosis, and enhance the myocardial force of contraction [1][2][3]. Testosterone functions Physiologically via combining with androgen receptor (AR), and AR exists in most of atrium, ventricle, aorta and coronary artery.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Serum Testosterone Level and Morning Pulse in Athletes

Ma¹

2013

Proceedings of the 2013 International Conference on Educational Research and Sports Education

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The present study aimed to investigate the relation between serum testosterone level and morning pulse of athletes during the summer training. The results showed values of serum testosterone and morning pulse were slightly changed on the beginning and end of the summer training, and the metaphase values of serum testosterone and morning pulse were both remarkably enhanced, compared with baseline. Furthermore, the serum testosterone level was markedly correlated with the morning pulse at four time points during the summer training above. In conclusion, there exists a significantly negative correlation between the serum testosterone level and the morning pulse in athletes during the summer training.

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Section: Discussionmentioning

confidence: 99%

Correlation of Serum Testosterone Level and Morning Pulse in Athletes

Ma¹

2013

Proceedings of the 2013 International Conference on Educational Research and Sports Education

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“…[71][72][73][74] The incidence of chronic heart failure due to idiopathic dilated cardiomyopathy is associated with a significant decrease in testosterone concentrations, 74 in which androgen replacement therapy could improve heart failure symptoms. 75 Several lines of evidence indicate that testosterone may effectively provide protective effects in the cardiovascular system 76,77 and that decreased circulating testosterone may increase cardiovascular risk, atherosclerosis, and mortality in men. 76,77 Testosterone therapy has also been shown to improve the cardiac ischemic condition, comparable to the effects of existing antianginal drugs but has no beneficial effects in peripheral arterial and cerebrovascular diseases.…”

Section: Testosterone and The Pathological Heartmentioning

confidence: 99%

Roles of Testosterone Replacement in Cardiac Ischemia–Reperfusion Injury

Pongkan¹,

Chattipakorn²

2015

J Cardiovasc Pharmacol Ther

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Testosterone is an anabolic steroid hormone, which is the major circulating androgen hormone in males. Testosterone levels decreasing below the normal physiological levels lead to a status known as androgen deficiency. Androgen deficiency has been shown to be a major risk factor in the development of several disorders, including obesity, metabolic syndrome, and ischemic heart disease. In the past decades, although several studies from animal models as well as clinical studies demonstrated that testosterone exerted cardioprotection, particularly during ischemia-reperfusion (I/R) injury, other preclinical and clinical studies have shown an inverse relationship between testosterone levels and cardioprotective effects. As a result, the effects of testosterone replacement on the heart remain controversial. In this review, reports regarding the roles of testosterone replacement in the heart following I/R injury are comprehensively summarized and discussed. At present, it may be concluded that chronic testosterone replacement at a physiological dose demonstrated cardioprotective effects, whereas acute testosterone replacement can cause adverse effects in the I/R heart.

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“…This may be due, in part, to abnormalities in ventricular mass, volume or function . Although many studies have not noted strong correlations between hypertension and testosterone levels, several reports have noted that low concentrations of endogenous testosterone correlate with higher blood pressure levels which would increase risk for left ventricular (LV) hypertrophy and heart failure . Through associations with CVD risk factors or apart from these risk factors, low testosterone concentrations have also been associated with increased prevalence of subclinical atherosclerosis and thus could increase risk of heart failure through ischaemia.…”

mentioning

confidence: 99%

Testosterone and cardiac mass and function in men with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

Kim

Bebu

Braffett

et al. 2016

Clinical Endocrinology

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Structured Summary Objective Low testosterone concentrations have been reported to be associated with increased risk of congestive heart failure, but the mechanisms are unclear. Our objectives was to examine the relationship between endogenous testosterone and measures of cardiac mass and function among men with type 1 diabetes. Design Secondary analysis of a prospective observational study. Participants Men (n=508) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial. Measurements Testosterone assessed by liquid chromatography mass spectrometry at EDIC year 10 and cardiac magnetic resonance imaging (CMR) measures at EDIC years 14/15. Linear regression models were used to assess the relationship between testosterone, sex hormone binding globulin (SHBG) and left ventricular (LV) mass, volume, ejection fraction, and cardiac index before and after adjustment for age, randomization arm, alcohol and cigarette use, macroalbuminuria, hemoglobin A1c, insulin dose, body mass index, lipids, blood pressure, use of anti-hypertensive medications, and microvascular complications. Results In fully-adjusted models, total testosterone concentrations were significantly associated with LV mass (p=0.014), end-diastolic volume (p=0.002), end-systolic volume (p=0.012), and stroke volume (p=0.022) but not measures of LV function after adjustment for cardiac risk factors. Bioavailable testosterone was associated with LV mass but not volume or function, while SHBG was associated with volume but not mass or function. Conclusions Among men with type 1 diabetes, higher total testosterone was associated with higher LV mass and volume but not with function. The clinical significance of this association remains to be established.

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Androgen Deficiency in Heart Failure

Cited by 9 publications

References 60 publications

Correlation of Serum Testosterone Level and Morning Pulse in Athletes

Correlation of Serum Testosterone Level and Morning Pulse in Athletes

Roles of Testosterone Replacement in Cardiac Ischemia–Reperfusion Injury

Testosterone and cardiac mass and function in men with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

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