Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

Brentani, Maria Mitzi; Franco, Eduardo L.; Oshima, Celina Tizuko Fujiyama; Pacheco, Mariana Poltronieri

doi:10.1002/ijc.2910380504

Cited by 25 publications

(7 citation statements)

References 24 publications

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“…Coexpression of steroid receptors was present for PgR and AR [17], only to a minor extent for ER and AR, contrasting with previous observations [4,21]. It seems noteworthy in this context, that PgR was reported to be of greater prognostic value for the disease free interval and for overall survival [27].…”

Section: Discussioncontrasting

confidence: 80%

Androgen receptors, serum androgen levels and survival of breast cancer patients

Langer¹,

Kubista²,

Schemper³

et al. 1990

Arch Gynecol Obstet

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Summary. Steroid receptor levels and serum androgen levels were determined in 61 breast cancer patients and 34 patients with non-malignant breast lesions. Testosterone and dehydroepiandrosterone-sulfate did not and androstenedione did show a difference between the two groups. Androgen levels had no influence on survival rates. Androgen receptor (AR) levels correlated with progesterone receptor levels, but not with estrogen receptor levels or with tumor stage. Patients with positive AR findings had a better survival rate; this was independent of tumor stage. AR findings may therefore be a prognostic index in breast cancer patients.

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Section: Discussioncontrasting

confidence: 80%

Androgen receptors, serum androgen levels and survival of breast cancer patients

Langer¹,

Kubista²,

Schemper³

et al. 1990

Arch Gynecol Obstet

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“…Therefore many authors maintain that knowing the status of all the three types of steroid receptors will facilitate predicting more accurately the response of patients to hormone therapy [16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Androgen receptors as a prognostic and predictive factor in breast cancer.

Agrawal

Jeleń²,

Grzebieniak³

et al. 2008

Folia Histochem Cytobiol.

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Many theoretical and experimental models indicate that androgen receptors can play an important role as prognostic factors in breast cancer. The aim of this study was to evaluate the correlations between the presence of androgen receptors on cancer cells and other selected prognostic and predictive factors with established clinical significance in women with breast cancer after radical surgical treatment. 488 adult females were included in the study, who underwent primary radical surgery for breast cancer. 428 patients (87.7%) had Patey's conservative radical mastectomy and 60 (12.3%) Halsted's radical mastectomy. The mean age at operation was 54.3, ranging from 32 to 79. The mean length of hospitalization was 7.2 days for the patients after Patey's mastectomy and 9.8 days for those after Halsted's mastectomy. The androgen receptor is the most frequently detected steroid receptor on breast cancer cells. Therapeutic efficacy of adjuvant hormone therapy was higher in the group of androgen receptor-positive patients than in androgen receptor-negative ones. The prognosis for androgen receptor-positive patients who underwent adjuvant hormone therapy was better than for those androgen receptor-positive patients who did not receive hormone therapy after primary radical surgery for breast cancer. Assessment of androgen receptor levels on cancer cells should become a routine procedure with patients undergoing primary radical surgery for breast cancer, as it seems to be an important predictive factor.

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“…In ,ical malignancy grades or nuclear dog uterus, ER and PR levels have been found to rise several-fold during the period of follicular oestrogen secretion above values in anoestrus. In metoestrus a decrease occurs to values slightly below those in anoestrus (Johnston ) (Allegra et al, 1979;Brentani et al, 1986 did not, may indicate an enhancement in the phenotypic expression of hormone receptors in tissues engaged in the process of malignant transformation (Cikes, 1978 . In the human, steroid receptor positivity of cancer metastases is more common, and receptor levels both in primary cancers as well as in metastases are often higher (Vihko et al, 1980;Wittliff, 1984), than in our series of dog cancers.…”

Section: Resultsmentioning

confidence: 99%

Oestrogen (ER) and progestin receptors (PR) in mammary tissue of the female dog: different receptor profile in non-malignant and malignant states

Rutteman

Misdorp²,

Blankenstein³

et al. 1988

Br J Cancer

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Summary Oestrogen (ER) and progestin receptors (PR) were measured in cytosols from histologically normal mammary tissues (n=30), and in benign (n=59) and malignant mammary lesions (n=49) from female dogs. Receptor levels .5 fmol mg-1 protein were considered positive. The presence of histologically normal mammary epithelium within specimens of primary tumours was noticed as a factor that may cause falsepositive receptor results. Receptor levels in non-malignant tissues, and the receptor status of primary cancers did not vary significantly with regard to the phase of oestrous cycle (anoestrus/metoestrus) or the influence of exogenous progestins. ER-or PR-positivity was more frequent and levels of both receptors were higher in 'normal' tissues and in benign lesions than in primary cancers (P<0.001). ER and PR levels were higher in benign lesions of dogs also developing malignant mammary tumours than in benign lesions of dogs that did not (P<0.02 and P<0.05, respectively). Regional and distant cancer metastases were frequently receptornegative. In some dogs heterogeneity of receptor status was found between different sites of the same cancer.These findings indicate that in non-malignant mammary tissues of adult female dogs expression of the genes encoding ER and PR is common. In malignant tumours this property may become lost, in particular in advanced states of disease.Mammary cancer in the dog and in the human have several features in common, including the spontaneous occurrence and the sparing effect of ovariohysterectomy if performed early in life (Schneider et al., 1969, Feinleib, 1968. Oestrogen (ER) and progestin receptors (PR) have been found in a large proportion of mammary cancers in both species (Raynaud et al., 1981;McGuire et al., 1982;Pierrepoint et al., 1984), indicating a role for sex steroid hormones in growth of such tumours. The receptor status of human breast cancer has become established as a useful predictor of the likelihood of response of the disease to endocrine therapy (McGuire et al., 1982) and has also been found to be related to the degree of differentiation (Fisher et al., 1987). These observations may be interpreted as indications that steroid receptor presence in a tumour reflects persistence of normal cell characteristics. It has been difficult, however, to detect substantial amounts of ER in adult normal human breast tissue (Wagner & Jungblut, 1976). This has led to the reverse view, namely, that expression of hormone receptors reflects a feature related to the process of neoplastic transformation (Israel & Band, 1984).The present study was undertaken in order to determine the ER and PR profile of histologically non-affected mammary glands and of benign and malignant (primary and/or metastatic) proliferative lesions in the dog. Results were related to histopathological and some clinical features of affected dogs. Results of a limited number of these determinations have been included in other reports Rutteman et al., , 1988 Those that were not used for ER/PR analysis were always exam...

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Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

Cited by 25 publications

References 24 publications

Androgen receptors, serum androgen levels and survival of breast cancer patients

Androgen receptors, serum androgen levels and survival of breast cancer patients

Androgen receptors as a prognostic and predictive factor in breast cancer.

Oestrogen (ER) and progestin receptors (PR) in mammary tissue of the female dog: different receptor profile in non-malignant and malignant states

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