Androgen Excess as a Major Determinant of Cardiovascular Risk in Women: Evidence from the Polycystic Ovary Syndrome

Pepene, Carmen Gerogescu

doi:10.4183/aeb.2011.529

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both insulin and testosterone promote endothelial cell dysfunction and hyperplasia, increasing cardiovascular risk. This is amplified by lipo-and glyco-oxidative stress and adipose tissue inflammation (9,13,14,20,21,44). LH -luteinizing hormone; SHBG -sex hormone-binding globulin; IGFBP1 -insulin-like growth factor binding protein1; ET1 -endothelin-1; AGE -Advanced Glycation Endproducts; HMW adiponectin -high molecular weight adiponectin; FFAfree fatty acids; SOD -superoxide dismutase; GPX4 -glutathione peroxidase 4.…”

Section: Pcom or Pcos?mentioning

confidence: 99%

Polycystic Ovary Syndrome Endocrine and Cardio-Metabolic Abnormalities: how to Manage?

Georgescu¹

2015

Acta Endo (Buc)

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS), the main cause of androgen excess in women of reproductive age, is a multifaceted, dynamic and clinically heterogenic disorder. Rotterdam 2003 ESHRE/ASRM definition criteria were recently reinforced at the NIH Consensus Meeting 2012. Concomitant identification of the clinical phenotypes of the syndrome is mandatory in medical care and clinical studies, as these are strongly related to reproductive, cardiovascular and metabolic outcomes. Documentation of polycystic ovarian morphology (PCOM) is challenging, with the AE/PCOS Task Force 2014 suggesting a threshold of ≥25 follicles/ovary in 18-35 years old women when using high-frequency transducers. Elevated levels of total testosterone and/or free testosterone and/or low sex hormone-binding globulin (SHBG) stand for androgen excess in women, as stated by the ESE Position Statement 2014. Despite evidence of increased metabolic and cardiovascular risk, increased prevalence of cardiovascular events linked to PCOS status per se is still insufficient documented, mainly because of the clinical heterogeneity of studies populations and lack of prospective data. First-line therapy in the medical management of PCOS is metformin, at least 1.5 g/d, in all patients with documented insulin resistance and hyperinsulinemia. According to Endocrine Society Guidelines 2013, other insulin-sensitizers (e.g. thiazolidinediones) raise safety concerns on the long-term, whereas statins need further evaluation to demonstrate their benefits in the treatment of PCOS, however, are indicated in dyslipidemic patients. Anti-androgens and combined oral contraceptives (COC) are targeting androgen excess, particularly in non-insulin resistant patients, with an overall benefit to risk ratio in PCOS favoring benefits.

show abstract

Section: Pcom or Pcos?mentioning

confidence: 99%

Polycystic Ovary Syndrome Endocrine and Cardio-Metabolic Abnormalities: how to Manage?

Georgescu¹

2015

Acta Endo (Buc)

View full text Add to dashboard Cite

show abstract

“…These include polycystic ovary syndrome (PCOS), hyperandrogenaemia, hypothalamic amenorrhoea, and functional hyperprolactinaemia (34,35). The most likely explanations for endocrine disorders related to epilepsy or antiepileptic drugs are: a direct influence of the epileptogenic lesion, epilepsy, or AEDs (36) on the endocrine control centres in the brain; the effects of AEDs on peripheral endocrine glands; the effects of AEDs on the metabolism of hormones and binding proteins; and secondary endocrine complications of AED-related weight changes or changes of insulin sensitivity (37) and direct insulin role in PCOS clinical signs (38).…”

Section: The Impact Of Epilepsy and Antiepileptic Drugs On Hormonal Cmentioning

confidence: 99%

Implications of Sex Hormones in the Treatment of Women with Epilepsy: Catamenial Epilepsy

Craiu¹

2014

Acta Endo (Buc)

View full text Add to dashboard Cite

The impact of sex hormones on body development is well known and extensively studied. It is important for physicians dealing with women with epilepsy (WWE) to understand the relationship between hormones -brain excitability -antiepileptic medication in the attempt of finding the most appropriate care for this population. This article presents current knowledge concerning 1. Influence of hormones on neuronal excitability and epilepsy (with general proconvulsant effect of estrogens and anticonvulsant of progesterone); 2. Role of sex hormones on brain development during puberty; 3. The influence of epilepsy and antiepileptic drugs (AEDs) on hormonal constellation, fertility and reproductive endocrine disorders including polycystic ovary syndrome; 4. Catamenial epilepsy (endocrinologists and neurologists should carefully investigate menstrual and epilepsy diaries, antiepileptic treatment and contraceptive method and choose treatment with either progesterone -for C1 menstrual type, or acetazolamide, benzodiazepines, antiepileptic medication for C2 and C3 types); 5. Contraception in WWE. Theoretical and practical issues are being discussed and organised into clinical practice recommendations.

show abstract

Lipidomics biomarkers in women with polycystic ovary syndrome (PCOS) using ultra-high performance liquid chromatography–quadrupole time of flight electrospray in a positive ionization mode mass spectrometry

Vonica

Ilie

Socaciu³

et al. 2019

Scandinavian Journal of Clinical and Laboratory Investigation

View full text Add to dashboard Cite

Androgen Excess as a Major Determinant of Cardiovascular Risk in Women: Evidence from the Polycystic Ovary Syndrome

Cited by 3 publications

References 21 publications

Polycystic Ovary Syndrome Endocrine and Cardio-Metabolic Abnormalities: how to Manage?

Polycystic Ovary Syndrome Endocrine and Cardio-Metabolic Abnormalities: how to Manage?

Implications of Sex Hormones in the Treatment of Women with Epilepsy: Catamenial Epilepsy

Lipidomics biomarkers in women with polycystic ovary syndrome (PCOS) using ultra-high performance liquid chromatography–quadrupole time of flight electrospray in a positive ionization mode mass spectrometry

Contact Info

Product

Resources

About