Androgen-induced accretion of ribonucleic acids in kidney of female mouse (Mus musculus)

Petrović, Silvana; Novaković, Milka B.; Tepavac, R. I.; Wilson, C. W. M.

doi:10.1016/0020-711x(77)90147-1

Cited by 13 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ability of androgens to increase the total RNA and the RNA/DNA ratio in male accessory organs and other susceptible organs has been documented in mammals (Frieden, 1964;DeLoecker, 1965;William-Ashman, 1965;Villee et al, 1975;Grigsby et al, 1976;Kochakian, 1964Kochakian, , 1975Kochakian, , 1976Kochakian, , 1977Liao, 1975Liao, , 1977Mainwaring, 1978;Petrovic et al, 1977). Comparable studies in fish are lacking.…”

Section: Discussionmentioning

confidence: 99%

The effect of feeding 11‐ketotestosterone on the food conversion efficiency and tissue protein and nucleic acid contents of juvenile carp, Cyprinus carpio L.

Lone

Matty

1982

Journal of Fish Biology

View full text Add to dashboard Cite

Juvenile common carp were fed 1 I-ketotestosterone for 60 days with the diet and the effect on food conversion efficiency, organ weights and protein and nucleic acids (RNA, DNA) content of the liver, kidney, brain and muscle were observed. Feeding of the steroid increased the food conversion efficiency of all the experimental groups studied as compared with controls. A decrease in weight of brain, liver and kidney in relation to body weight was noticed after 60 days of the hormone feeding. No change in the visceral weight was observed. These changes in relative weights of the organ were ameliorated 30 days after the withdrawal ofthe steroid from the food. The weight ofthe viscera decreased compared with the control weight during this time. Feeding ofthe hormone brought variable changes in the total proteins, RNA/DNA, protein/RNA and protein/DNA in all the organs studied. In addition to these findings, changes in the moisture, total lipid and ash contents ofthe muscle were also observed. The results are discussed in the light of existing knowledge of the effect of anabolic-androgenic steroids on the growth processes of different organisms.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of feeding 11‐ketotestosterone on the food conversion efficiency and tissue protein and nucleic acid contents of juvenile carp, Cyprinus carpio L.

Lone

Matty

1982

Journal of Fish Biology

View full text Add to dashboard Cite

show abstract

“…It has been shown by many studies that androgens produce an increase in renal weight in rats [13,18,19]; it is widely believed that males have larger kidneys than females [1,4,20,21]. However, kidney weight does not vary linearly with body weight [22].…”

Section: Discussionmentioning

confidence: 99%

Differences in Rat Kidney Morphology between Males, Females and Testosterone-Treated Females

Oudar

Elger

Bankir

et al. 1991

Kidney Blood Press Res

View full text Add to dashboard Cite

Kidneys of normal female and male Wistar-Kyoto rats were studied by standard morphological techniques and morphometry in order to evaluate possible differences in the overall kidney morphology between both sexes. Furthermore, we investigated the role of testosterone (DHT) on kidney morphology by treating females with daily DHT injections. Kidney weight and volume in relation to body weight were not significantly different between males and females and were not affected by DHT. Differences were found in the volume distribution among the kidney zones. The cortex was larger in males than in females, whereas the medulla was conspicuously larger in females than in males. The greater volume of the cortex in males was mainly due to a more extensive development of proximal tubules. DHT treatment in females increased the volume of their proximal tubules. Glomerular volume was similar among the three groups. Within the medulla, the difference was most prominent in the inner stripe (14.9% of the total kidney volume in females vs. 8.9% in males) and was also important in the inner medulla (7.0 vs. 4.8%). The absolute epithelial volume of thick ascending limbs in this zone was larger in females than in males. This difference was more pronounced in short loops (≈20%) than in long loops (≈10%). The values of the DHT-treated females ranged in between. In spite of the greater development of medulla and thick ascending limbs in females, urine concentration was higher in males than in females and maximum urinary concentrating ability after 48 h dehydration was not different between both sexes.

show abstract

“…The fact that in the present study, some groups particularly in muscle had higher RNA/DNA whh no growth response is due to the specific action of steroids on the transcription of RNA and this is a more regular effect in kidneys than other organs (Petrovic et al 1977). This effect probably was also responsible for the increased RSI seen in the experimental animals (discussed above).…”

Section: Discussionmentioning

confidence: 49%

The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio)

Lone

1989

Fish Physiol Biochem

View full text Add to dashboard Cite

A study on the effect of three different anabolic-androgenic steroids on the growth, food conversion efficiency and nucleic acid contents of liver, kidney, brain and muscle of carp,Cyprinus carpio was undertaken. The three steroids, methyltestosterone (MT), ethylestrenol (EE) and oxandrolone (ON), were fed in different combinations at final concentrations of 5 or 6 mg/kg diet for 60 days. No effect on the growth was observed in any of the experimental groups. A decrease in the specific growth rate (11-21%) and food conversion efficiency (20-29%) was noted. Feeding of drugs increased the cranio-somatic and reno-somatic index in all except one group. Hepatosomatic (ON+MT) and viscero-somatic (ON+MT; EE+MT+ON) indices decreased. Protein increased and RNA/DNA decreased in only one group while a decrease in protein/DNA was observed in the liver of all experimental groups. RNA/DNA increased and protein/RNA decreased only in one group while no effect was seen in protein and protein/DNA contents in any of the treated kidneys. Proteins, protein/RNA and protein/DNA decreased in certain groups in brain tissue. In muscle, no effect was seen in proteins or protein/DNA. Protein/RNA decreased in all but one group while RNA/DNA was higher only in the group fed all the three steroids together.

show abstract

Androgen-induced accretion of ribonucleic acids in kidney of female mouse (Mus musculus)

Cited by 13 publications

References 21 publications

The effect of feeding 11‐ketotestosterone on the food conversion efficiency and tissue protein and nucleic acid contents of juvenile carp, Cyprinus carpio L.

The effect of feeding 11‐ketotestosterone on the food conversion efficiency and tissue protein and nucleic acid contents of juvenile carp, Cyprinus carpio L.

Differences in Rat Kidney Morphology between Males, Females and Testosterone-Treated Females

The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio)

Contact Info

Product

Resources

About