Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

Itami, Satoshi; Kurata, Sotaro; Takayasu, Susumu

doi:10.1006/bbrc.1995.2067

Cited by 172 publications

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“…beard) whilst inhibiting others, as in male pattern baldness, altering the production of regulatory factors. Dermal papilla cells have been shown to secrete extracellular matrix components and mitogenic factors in culture , Itami et al 1995 and, very recently, it has been reported that androgens inhibit the production of mitogenic factors by cultured human balding scalp dermal papilla cells and those of the macaque , Obana & Uno 1996. Further investigations using this model system should contribute to our understanding of the mechanisms of androgen action in androgenetic alopecia, and should lead, hopefully, to better treatments for this condition.…”

Section: Discussionmentioning

confidence: 99%

“…The culture of dermal papilla cells from the larger non-balding scalp and body hair follicles is well established (Messenger 1984) and they appear to offer a useful model for studying the action of androgens. Dermal papilla cells in vitro have been shown to retain their in vivo inductive properties (Reynolds & Jahoda 1991) and to display properties which are dependent on their in vivo sensitivities to androgens (Itami et al 1991, Randall et al 1992, Thornton et al 1993, Itami et al 1995. The correlation between the patterns of testosterone metabolism by dermal papilla cells derived from beard, scalp, pubic and axillary hair follicles (Itami et al 1991, Thornton et al 1993 and hair growth in 5 -reductase deficiency syndromes (ImperatoMcGuinley et al 1991) strongly supports the hypothesis that androgens act via the dermal papilla.…”

Section: Introductionmentioning

confidence: 89%

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Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Hibberts

Howell²,

Randall³

1998

Journal of Endocrinology

233

154

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Androgens can gradually transform large scalp hair follicles to smaller vellus ones, causing balding. The mechanisms involved are unclear, although androgens are believed to act on the epithelial hair follicle via the mesenchymederived dermal papilla. This study investigates whether the levels and type of androgen receptors in primary lines of cultured dermal papilla cells derived from balding scalp hair follicles differ from those of follicles from non-balding scalp.Androgen receptor content was measured by saturation analysis using the non-metabolisable androgen, [3 H]mibolerone (0·05-10 nM) in a 9-10 point assay. Pubic dermal fibroblasts and Shionogi cells were examined as positive controls. Repetitive assays of Shionogi cells showed good precision in the levels of androgen receptor content (coefficient of variation=3·7%). Specific, high affinity, low capacity androgen receptors were detected in dermal papilla cells from both balding and non-balding follicles. Balding cells contained significantly (P<0·01) greater levels of androgen receptors (B max =0·06 0·01 fmol/10 4 cells (mean ...)) than those from non-balding scalp (0·04 0·001). Competition studies with a range of steroids showed no differences in receptor binding specificity in the two cell types.The higher levels of androgen receptors in cells from balding scalp hair follicles with similar properties to those from non-balding scalp concur with the expectations from their in vivo responses to androgens. This supports the hypothesis that androgens act via the dermal papilla and suggests that cultured dermal papilla cells may offer a model system for studying androgen action in androgenetic alopecia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Hibberts

Howell²,

Randall³

1998

Journal of Endocrinology

233

154

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“…The relationship between insulin resistance and IH is not explained well. One explanation for this association might be stimulating effect of insulin/insulin-like growth factor (IGF) system on hair follicle growth [24]. Phillot et al [25] also demonstrated that insulin/IGF system in vitro has a role on hair follicle growth.…”

Section: Isi Homamentioning

confidence: 99%

Evaluation of various insulin sensitivity indices in lean idiopathic hirsutism patients

2012

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Hirsutism is characterized by excessive growth of terminal hair in a male pattern. Excessive hair growth in the absence of demonstrable androgen excess in ovulatory women is also referred to as idiopathic hirsutism (IH). IH is diagnosed in women who have hirsutism, normal ovulatory function and normal total or free testosterone levels. IH is a common cause of hirsutism. IH is not associated with any sign of virilization. Its cause is not understood completely. It has been proposed that women with IH have significantly increased cutaneous 5α-reductase activity. The presence or absence of such an association is not clear [1].Polycystic ovary syndrome (PCOS), another cause of hirsutism, is an insulin resistance related syndrome. Abstract. Hirsutism is characterized by excessive growth of terminal hair in a male pattern. Idiopathic hirsutism (IH) is a common cause of hirsutism. Since there are few data demonstrating IH is associated with insulin resistance, we tried to assess various insulin sensitivity indices in lean IH and compare with healthy subjects. A cross-sectional study was performed in 71 lean (BMI between 20-25 kg/m 2 ) women (17-39 years old), 31 with IH and 40 healthy individuals. Blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), hepatic insulin sensitivity (ISI HOMA ), Quicky index, reciprocal fasting insulin resistance index, fasting Belfiore index, and fasting glucose/insulin ratio (GIR) were estimated using a single fasting sample of glucose and insulin levels. Raynaud indices calculated using the mathematical estimation in a single fasting sample of insulin levels were determined and compared in two groups. Fasting insulin, Raynaud index, HOMA-IR and Fasting insulin resistance index (FIRI) results were higher in IH group than in controls (p<0.01, for all). Fasting Belfiore index, QUICKI index, ISI HOMA and FIRI -1 results were lower in IH group than in controls (p<0.01, for all). Our study showed that lean IH patients were more insulin resistant than healthy subjects. We propose that insulin sensitivity indices are useful methods for measuring insulin resistance in IH.Key words: Idiopathic hirsutism, Insulin resistance, Lean patients, Insulin sensitivity indices insulin resistance. There are few data demonstrating IH is associated with insulin resistance. Since the pathogenesis of IH is still unclear, we tried to assess various insulin sensitivity indices in lean IH and compare with healthy subjects. materials and methodsA cross-sectional study was performed in 71 lean (BMI between 20-25 kg/m 2 ) women (17-39 years old), 31 with IH and 40 healthy individuals. The protocol was approved by the hospital-based ethics committee. The protocol of the study was explained to all of the subjects. Informed consent was obtained before beginning the study.None of the control subjects had ovarian dysfunction, hirsutism, or hyperandrogenemia. The diagnosis of IH was based on the presence of hirsutism (modified Ferriman-Gallwey score, >8) [2], regular ovulatory menstrual cycles...

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“…In this model, androgens act directly on DP cells where they bind to androgen receptors and then initiate altered gene expression of regulatory factors modulating indirectly the period of time when hair is growing, size and activity of the DP, keratinocytes and melanocytes. The factors produced by these populations may be soluble paracrine factors and/or extracellular matrix factors, including insulin-like growth factor-1 (IGF-1) in growth stimulation [105], stem cell factor in altered pigmentation [102] and transforming growth factor-b [106,107] and dickkopf 1 [108] in inhibition. The opposite effects of androgens on beard and scalp follicles probably reflect differences in androgen receptor content, which is higher in beard DP than in occipital hair DP [109] and/or 5a-reductase activity, which is higher in beard than in scalp [110].…”

Section: Molecular Control Of Hair Follicle Development and Cyclingmentioning

confidence: 99%

Biology of Human Hair: Know Your Hair to Control It

Araújo

Fernandes

Cavaco‐Paulo

et al. 2010

Advances in Biochemical Engineering/Biotechnology

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Hair can be engineered at different levels-its structure and surfacethrough modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based applications. General aspects of hair biology are reviewed, as well as the most recent contributions to understanding hair pigmentation and the regulation of hair development. Focus will also be placed on the techniques developed specifically for delivering compounds of varying chemical nature to the HF, indicating methods for genetic/biochemical modulation of HF components for the treatment of hair diseases. Finally, hair fiber structure and chemical characteristics will be discussed as targets for keratin surface functionalization.

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Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

Cited by 172 publications

References 0 publications

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Evaluation of various insulin sensitivity indices in lean idiopathic hirsutism patients

Biology of Human Hair: Know Your Hair to Control It

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