Androgen Insensitivity Syndrome with Gynandroblastoma and Vulvar Leiomyoma

Tian, Wenyan; Wang, Yingmei; Zhang, Huiying; Liu, Guoyan; Ma, Xuegong; Xue, Fengxia

doi:10.1097/lgt.0b013e3182702796

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…Later similar syndrome was reported by others too [6–9]. Very recently Tian et al reported a case of 64-year-old female (phenotypically) with androgen insensitivity syndrome having bilateral vulval leiomyoma [10]. …”

Section: Discussionsupporting

confidence: 53%

Leiomyoma in Vulva: A Diagnostic Dilemma

Pandey

Shetty

Saxena

et al. 2014

Case Reports in Obstetrics and Gynecology

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With the help of this case we summarize some crucial features to be picked up from history and examination before labeling a case as Bartholin's abscess or cyst. A 20-year old unmarried girl, deaf and mute since birth, was initially diagnosed to have Bartholin's abscess. On careful reexamination after inflammation subsided, a decision of excision of this tumor was taken. Intraoperatively it was found to be well encapsulated. Histopathology ascertained the diagnosis of vulval leiomyoma.

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Section: Discussionsupporting

confidence: 53%

Leiomyoma in Vulva: A Diagnostic Dilemma

Pandey

Shetty

Saxena

et al. 2014

Case Reports in Obstetrics and Gynecology

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“…Most patients presented with a long history of a painless mass. 4 , 12 , 14 , 27 , 28 Because the mass usually remains small (often for 10–20 years) 10 , 12 , 27 and grows slowly in the early period, many patients do not initially see a physician. As the mass increases in size, patients often have difficulty walking, sitting, or having intercourse.…”

Section: Results (Table 1)mentioning

confidence: 99%

“…The most common presentation of vulvar leiomyoma is a painless mass 4 , 12 , 14 , 27 , 28 in the clitoris or labium minora. 24 On physical examination, palpation usually reveals a non-tender mass with firm consistency and partial mobility.…”

Section: Discussionmentioning

confidence: 99%

Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor

et al. 2017

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The objective of this article is to discuss the pathophysiology, diagnosis, differential diagnosis, and therapy of vulvar leiomyoma. We performed a review of all English-language reports of vulvar leiomyoma published in PubMed from 1978 to 2015 using the following search terms: “vulval leiomyoma,” “vulvar leiomyoma,” “vulval smooth muscle tumor,” and “external genitalia smooth muscle tumor.” Vulvar leiomyomas, which are rare benign monoclonal tumors, most commonly occur in the fourth and fifth decades of life. The genetics of vulvar leiomyoma remain undefined. Three principal histological patterns have been identified: spindled, epithelioid, and myxoid. Imaging tests such as ultrasound, endoscopic ultrasound, and magnetic resonance imaging are used in diagnosis. Surgical excision is the only curative treatment for vulvar leiomyomas. Establishment of a full differential diagnosis list and correct final diagnosis before surgery are essential for optimal clinical management. Although recurrence of vulvar leiomyoma is extremely rare, long-term follow-up of all cases is advisable.

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“…The histogenesis of gynandroblastoma is unknown, but it is generally assumed that it originates from a single progenitor cell that can differentiate into both female and male elements [ 11 ]. During embryogenesis, gonadal tissues develop from the mesoderm of the urogenital ridge and the ridge organizes the endocrinologically active tissues of the gonad, which includes granulosa cells, Sertoli cells, theca cells, ovarian stromal cells, and Leydig cells [ 12 ]. Gynandroblastoma and other sex cord-stromal tumors are considered to have their origin in the cells of the urogenital ridge.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review

Jang

Lee

Jang

et al. 2018

J Pathol Transl Med

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Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Pelvic computed tomography showed a large multilocular cystic mass, suspected to be of ovarian origin. We performed a total abdominal hysterectomy (total abdominal hysterectomy was performed) with bilateral salpingo-oophorectomy. A 13-cm multilocular cystic mass with serous fluid was observed in her right ovary. Upon microscopic examination, the solid component of the mass showed both Sertoli-Leydig cell and juvenile granulosa cell differentiation, which we diagnosed as gynandroblastoma. Gynandroblastoma with a juvenile granulosa cell tumor component is extremely rare and, until now, only six cases have been reported in the English literature. We report the first gynandroblastoma with a juvenile granulosa cell tumor component diagnosed in an elderly patient, along with a literature review.

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Androgen Insensitivity Syndrome with Gynandroblastoma and Vulvar Leiomyoma

Cited by 6 publications

References 10 publications

Leiomyoma in Vulva: A Diagnostic Dilemma

Leiomyoma in Vulva: A Diagnostic Dilemma

Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review

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