Androgen Levels in Older Men Who Have or Who Are at Risk of Acquiring HIV Infection

Klein, Robert S.; Lo, Yungtai; Santoro, Nanette; Dobs, Adrian S.

doi:10.1086/498311

Cited by 71 publications

(81 citation statements)

References 37 publications

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“…The small yet significant difference in sexual activity between HIV-positive and HIV-negative men may be due in part to the significantly greater prevalence of erectile dysfunction among the HIV-positive men. Studies have indicated that HIV infection may be related to decreased androgen levels and erectile dysfunction (Cove & Petrak, 2004;Jung & Schill, 2004;Klein et al, 2005). In fact, a significantly greater percentage of the HIV-positive men in our sample reported taking sildenafil in the past 6 months and ever talking testosterone or other male hormones during their lifetime.…”

Section: Discussionmentioning

confidence: 57%

“…The Cohort of HIV At-Risk Aging Men's Prospective Study (CHAMPS) is an ongoing longitudinal study of selected outcomes in older men with or at risk for HIV infection (Klein, Lo, Santoro, & Dobs, 2005). Participants were recruited through word of mouth, flyers in HIV and medical clinics, advertisements in the community, and research staff presentations at HIV community groups.…”

Section: Methodsmentioning

confidence: 99%

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Current Sexual Activity and Risky Sexual Behavior in Older Men With or At Risk for HIV Infection

Cooperman

Arnsten

Klein

2007

AIDS Education and Prevention

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In a cross-sectional analysis, we investigated frequency of sexual activity and factors associated with risky sexual behavior among 624 older men, aged 49−80, with or at risk for HIV infection. During the prior 6 months, 75% reported sexual activity with at least one partner, and one quarter of both the HIV-negative and HIV-positive men had more than one sexual partner. Only 18% of the HIVnegative men and 58% of the HIV-positive men always used condoms with their sexual partners. Factors independently and positively associated with risky sexual behavior included lack of HIV infection, any drug use in the past 6 months, greater importance of sex in one's life, weekly or more frequent sexual activity in the past 6 months, and ever taking sildenafil. These results suggest that older men with or at risk for HIV infection are sexually active, participate in risky sexual behavior, and need safer sex interventions.

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Section: Discussionmentioning

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Current Sexual Activity and Risky Sexual Behavior in Older Men With or At Risk for HIV Infection

Cooperman

Arnsten

Klein

2007

AIDS Education and Prevention

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“…SHBG and 17-OHP were assayed using commercially available reagents from Diagnostic Products Corporation (DPC) (Los Angeles, CA: SHBG sensitivity 0.5nmol/L, intra-assay CV 4.3% and inter-assay CV 8.6%). (19,20) Androstenedione was measured in duplicate using the Coat-aCount assay from DPC (sensitivity 0.140 nmol/L, intra-assay CV 5.7 % and inter-assay CV 8.4%). Serum glucose was analyzed by the Olympus AU400 Chemistry Autoanalyzer using the Olympus Glucose Kit.…”

Section: Methodsmentioning

confidence: 99%

Body Shape and Size and Insulin Resistance as Early Clinical Predictors of Hyperandrogenic Anovulation in Ethnic Minority Adolescent Girls

Rieder¹,

Santoro²,

Cohen³

et al. 2008

Journal of Adolescent Health

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“…Participant recruitment and study design for both studies have been described previously. 35,36 In brief, Ms-enrolled women aged 35- Recruitment for both cohorts was from methadone maintenance clinics, primary care clinics, community newsletters, health fairs, word-of-mouth, and a prior research cohort. Ms and CHAMPS shared similar methodology and data collection tools so that the outcomes of interest could be compared by gender.…”

Section: Study Participantsmentioning

confidence: 99%

Use of Complementary and Alternative Medicine in Inner-City Persons with or at Risk for HIV Infection

Milan

Arnsten

Klein

et al. 2008

AIDS Patient Care and STDs

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Previous studies have shown that use of complementary and alternative medicine (CAM) is prevalent among HIV-infected persons, but have focused primarily on men who have sex with men. To determine factors associated with CAM use in an inner city population, individuals (n ϭ 93) recruited from two established cohort studies were interviewed between October and November 2004. The interview assessed the use of dietary supplements and other CAM therapies, reasons for CAM use, and use of prescription medications. Study participants were 52% male and 47% HIV infected. Median age was 50 years, and 60% reported illicit drug use ever. CAM use during the prior 6 months was reported by 94%, with 48% reporting daily use of a dietary supplement. Vitamin C, vitamin E, and soy were used more often by HIV-infected than uninfected persons (p Ͻ 0.05). Prevention of illness was the most common reason for dietary supplement use (27%). HIV-infected persons were more likely than uninfected persons (95% versus 67%) to report use of both dietary supplements and prescription medications within the past 6 months (p Ͻ 0.001). In multivariate analysis, HIV infection (odds ratio [OR] 3.1, CI 1.3, 7.7) was the only factor associated with daily dietary supplement use whereas gender, race/ethnicity, working in the last year, homelessness, and financial comfort were not associated. CAM use among persons with or at risk for HIV infection due to drug use or high-risk heterosexual behaviors is common, and is used almost exclusively as an adjunct and not an alternative to conventional health care. 811

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Androgen Levels in Older Men Who Have or Who Are at Risk of Acquiring HIV Infection

Abstract: Most older men at risk for HIV infection have low androgen levels. Injection drug use, high body mass index, HCV infection, and use of psychotropic medications are associated with low androgen levels, and low androgen levels are associated with symptoms of hypogonadism.

Cited by 71 publications

References 37 publications

Current Sexual Activity and Risky Sexual Behavior in Older Men With or At Risk for HIV Infection

Current Sexual Activity and Risky Sexual Behavior in Older Men With or At Risk for HIV Infection

Body Shape and Size and Insulin Resistance as Early Clinical Predictors of Hyperandrogenic Anovulation in Ethnic Minority Adolescent Girls

Use of Complementary and Alternative Medicine in Inner-City Persons with or at Risk for HIV Infection

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