Androgen receptor and vitamin D receptor in human ovarian cancer: Growth stimulation and inhibition by ligands

Ahonen, Merja; Zhuang, Yibo; Aine, Risto; Ylikomi, Timo; Tuohimaa, Pentti

doi:10.1002/(sici)1097-0215(20000401)86:1<40::aid-ijc6>3.0.co;2-e

Cited by 108 publications

(100 citation statements)

References 28 publications

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“…36,37 Further supporting a role for vitamin D in protection from cancer is the finding that genetic polymorphisms in the vitamin D receptor are associated with different mortality rates for breast, 38 colon, 39,40 prostate, 41 and rectal carcinomas. 42 The addition of vitamin D to cells from prostate carcinoma, 43 colon carcinoma, 34 melanoma, 44 NHL, 45 ovarian carcinoma, 46 and renal carcinoma 47 decreases the proliferation of these cells or induces differentiation in other cell types such as colonic HT 29 cells 48 and endometrial carcinoma cell lines. 49 Previous studies examining the effect of solar UV-B on malignancy used other measures of solar radiation including average annual solar radiation and SO 2 2,12 and haze.…”

Section: Discussionmentioning

confidence: 99%

An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet‐B radiation

Grant

2002

Cancer

659

441

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BACKGROUNDThere are large geographic gradients in mortality rates for a number of cancers in the U.S. (e.g., rates are approximately twice as high in the northeast compared with the southwest). Risk factors such as diet fail to explain this variation. Previous studies have demonstrated that the geographic distributions for five types of cancer are related inversely to solar radiation. The purpose of the current study was to determine how many types of cancer are affected by solar radiation and how many premature deaths from cancer occur due to insufficient ultraviolet (UV)‐B radiation.METHODSUV‐B data for July 1992 and cancer mortality rates in the U.S. for between 1970–1994 were analyzed in an ecologic study.RESULTSThe findings of the current study confirm previous results that solar UV‐B radiation is associated with reduced risk of cancer of the breast, colon, ovary, and prostate as well as non‐Hodgkin lymphoma. Eight additional malignancies were found to exhibit an inverse correlation between mortality rates and UV‐B radiation: bladder, esophageal, kidney, lung, pancreatic, rectal, stomach, and corpus uteri. The annual number of premature deaths from cancer due to lower UV‐B exposures was 21,700 (95% confidence interval [95% CI], 20,400–23,400) for white Americans, 1400 (95% CI, 1100–1600) for black Americans, and 500 (95% CI, 400–600) for Asian Americans and other minorities.CONCLUSIONSThe results of the current study demonstrate that much of the geographic variation in cancer mortality rates in the U.S. can be attributed to variations in solar UV‐B radiation exposure. Thus, many lives could be extended through increased careful exposure to solar UV‐B radiation and more safely, vitamin D3 supplementation, especially in nonsummer months. Cancer 2002;94:1867–75. © 2002 American Cancer Society.DOI 10.1002/cncr.10427

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Section: Discussionmentioning

confidence: 99%

An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet‐B radiation

Grant

2002

Cancer

659

441

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“…Here, we assumed a spherical tumor with the radius being one-half the major axis, using the volume of the sphere to estimate the cell number. For those papers that reported relative volume, we converted the data to cell number using the information in the supplemental material sections of each paper (Okegawa et al, 2001;Fujiwara et al, 1993;Ahonen et al, 2000).…”

Section: Unit Normalizationmentioning

confidence: 99%

A Comparison and Catalog of Intrinsic Tumor Growth Models

2014

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Determining the dynamics and parameter values that drive tumor growth is of great interest to mathematical modelers, experimentalists and practitioners alike. We provide a basis on which to estimate the growth dynamics of ten different tumors by fitting growth parameters to at least five sets of published experimental data per type of tumor. These timescale tumor growth data are also used to determine which of the most common tumor growth models (exponential, power law, logistic, Gompertz, or von Bertalanffy) provides the best fit for each type of tumor. In order to compute the best-fit parameters, we implemented a hybrid local-global least squares minimization algorithm based on a combination of Nelder-Mead simplex direct search and Monte Carlo Markov Chain methods.

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“…70 Vitamin D inadequacy constitutes a largely unrecognized epidemic in many populations worldwide [71][72][73] It has been reported in healthy children, 74 adolescents 75 and adults. 76,77 Vitamin D and prostate health Normal and malignant prostate cells contain VDRs, [78][79][80] which mediate the antiproliferative action of 1,25(OH)2D. 1,25(OH)2D, the biologically active form of vitamin D, binds to nuclear VDRs in the epithelial cells of the prostate.…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

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Prostate cancer is the most commonly diagnosed cancer in the United States. Prostate cells contain vitamin D receptors as well as enzymes necessary for vitamin D metabolism. Vitamin D metabolites have an antiproliferative and a pro-differentiating effect on prostate cancer cell lines in vitro and in vivo. As a result, there has been an emerging interest in the potential role of vitamin D in the etiology of prostate cancer. This review summarizes all available epidemiological literature on the association between dietary vitamin D, circulating levels of vitamin D and sunlight exposure in relation to prostate cancer risk. To place these studies in context, we also provide some background information on vitamin D, such as its dietary sources, metabolism, optimal levels, hypovitaminosis and relationship with the prostate.

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Androgen receptor and vitamin D receptor in human ovarian cancer: Growth stimulation and inhibition by ligands

Cited by 108 publications

References 28 publications

An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet‐B radiation

An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet‐B radiation

A Comparison and Catalog of Intrinsic Tumor Growth Models

Vitamin D and prostate cancer risk: a review of the epidemiological literature

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