Androgen regulated TRPM8 expression: A potential mRNA marker for metastatic prostate cancer detection in body fluids

Bai, V. Uma; Murthy, Shalini; Chinnakannu, Kannagi; Muhletaler, Fred; Tejwani, Sheela; Barrack, Evelyn R.; Kim, Sahn‐Ho; Menon, Mani; Reddy, G. Prem Veer

doi:10.3892/ijo_00000518

Cited by 17 publications

(1 citation statement)

References 36 publications

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“…Since TRPM8 is activated by cold temperatures, this channel is considered the molecular entity responsible for cold transduction in peripheral nerves (204). In the context of cancer, TRPM8 has been strongly involved in prostate cancer wherein it is related to tumor staging (205,206). Moreover, this channel was found overexpressed in others types such as glioblastoma (207), pancreatic cancer (208), melanoma (209) and breast cancer (210).…”

Section: Trpm8mentioning

confidence: 99%

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

et al. 2021

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Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused 627,000 deaths in 2018. Since cancer is a multifactorial disease, it has become necessary to develop new molecular therapies that can target several relevant cellular processes at once. Ion channels are versatile regulators of several physiological- and pathophysiological-related mechanisms, including cancer-relevant processes such as tumor progression, apoptosis inhibition, proliferation, migration, invasion, and chemoresistance. Ion channels are the main regulators of cellular functions, conducting ions selectively through a pore-forming structure located in the plasma membrane, protein–protein interactions one of their main regulatory mechanisms. Among the different ion channel families, the Transient Receptor Potential (TRP) family stands out in the context of breast cancer since several members have been proposed as prognostic markers in this pathology. However, only a few approaches exist to block their specific activity during tumoral progress. In this article, we describe several TRP channels that have been involved in breast cancer progress with a particular focus on their binding partners that have also been described as drivers of breast cancer progression. Here, we propose disrupting these interactions as attractive and potential new therapeutic targets for treating this neoplastic disease.

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Section: Trpm8mentioning

confidence: 99%

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

et al. 2021

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TRPM8: a potential target for cancer treatment

Liu

Wei

et al. 2016

J Cancer Res Clin Oncol

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Transient receptor potential (TRP) cation channel superfamily plays critical roles in variety of processes, including temperature perception, pain transduction, vasorelaxation, male fertility, and tumorigenesis. One of seven families within the TRP superfamily of ion channels, the melastatin, or TRPM family comprises a group of eight structurally and functionally diverse channels. Of all the members of TRPM subfamily, TRPM8 is the most notable one. A lot of literatures have demonstrated that transient receptor potential melastatin 8 (TRPM8) could perform a myriad of functions in vertebrates and invertebrates alike. In addition to its well-known function in cold sensation, TRPM8 has an emerging role in a variety of biological systems, including thermoregulation, cancer, bladder function, and asthma. Recent studies have shown that TRPM8 is necessary to the initiation and progression of tumors, and the aberrant expression of TRPM8 was found in varieties of tumors, such as prostate tumor, melanoma, breast adenocarcinoma, bladder cancer, and colorectal cancer, making it a novel molecular target potentially useful in the diagnosis and treatment of cancer. This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.

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Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain

et al. 2015

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The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary cold sensor in humans. TRPM8 is gated by physiologically relevant cold temperatures and chemical ligands that induce cold sensations, such as the analgesic compound menthol. Characterization of TRPM8 ligand-gated channel activation will lead to a better understanding of the fundamental mechanisms that underlie TRPM8 function. Here, the direct binding of menthol to the isolated hTRPM8 sensing domain (transmembrane helices S1–S4) is investigated. These data are compared with two mutant sensing domain proteins, Y745H (S2 helix) and R842H (S4 helix), which have been previously identified in full length TRPM8 to be menthol insensitive. The data presented herein show that menthol specifically binds to the wild type, Y745H, and R842H TRPM8 sensing domain proteins. These results are the first to show that menthol directly binds to the TRPM8 sensing domain and indicates that Y745 and R842 residues, previously identified in functional studies as crucial to menthol sensitivity, do not affect menthol binding but instead alter coupling between the sensing domain and the pore domain.

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Androgen regulated TRPM8 expression: A potential mRNA marker for metastatic prostate cancer detection in body fluids

Cited by 17 publications

References 36 publications

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

TRPM8: a potential target for cancer treatment

Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain

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