Androgen Sulfation in Healthy UDP-Glucuronosyl Transferase 2B17 Enzyme-Deficient Men

Schulze, Jenny J.; Thörngren, John‐Olof; Garle, Mats; Ekström, Lena; Rane, Anders

doi:10.1210/jc.2011-0521

Cited by 35 publications

(63 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As an example, enzymes CYP11A1 and CYP17 from the CYP450 family participate in the modification of cholesterol to yield T,62 which is then converted to biologically more active DHT by steroid 5α-reductase type 2 enzyme (SRD5A2) in the prostate 63 64. For rational targeting of analysis and appropriate result interpretation in doping control and for ABP purposes, however, the bioprocesses concerning metabolism and urinary excretion, and interindividual variability within these processes, are of major importance.…”

Section: Abp and The Steroidal Modulementioning

confidence: 99%

Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

2014

View full text Add to dashboard Cite

In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix. For a comprehensive and scientific evaluation of the urinary steroid profile, it is necessary to define the target analytes as well as testosterone metabolism. The two main confounding factors, that is, endogenous and exogenous factors, are detailed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Technical aspects are also discussed as they could have a significant impact on the steroid profile, and thus the steroid module of the athlete biological passport (ABP). The different factors impacting the major components of the steroid profile must be understood to ensure scientifically sound interpretation through the Bayesian model of the ABP. Not only should the statistical data be considered but also the experts in the field must be consulted for successful implementation of the steroidal module.

show abstract

Section: Abp and The Steroidal Modulementioning

confidence: 99%

Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

2014

View full text Add to dashboard Cite

show abstract

“…UGT2B17 is a member of the uridine diphosphoglucuronosyltransferase (UGT) protein family and catalyzes the glucuronidation of a diverse range of substrates including steroid hormones and lipid-soluble drugs. 4,5 Therapies commonly used in CLL such as those in the FC regimen are not known to be influenced by UGT2B17. Gruber and colleagues preliminarily tried to explore how UGT2B17 For personal use only.…”

Section: Ugt2b17 As a Disease Accelerator In Cllmentioning

confidence: 99%

“…Lentiviral vector constructs, as used in the current report, have been shown to be highly effective in terms of transduction because of their ability to infect both replicating and nonreplicating cells, including hematopoietic stem cells. Current data from experimental systems indicate that lentiviruses have significantly lower genotoxicity compared with the long terminal repeat-driven ␥-retroviral retroviruses used in earlier trials of gene therapy in other immunodeficiencies that resulted in cases of leukemogenesis directly linked to the therapy: X-linked severe combined immunodeficiency (SCID), 3 Wiskott Aldrich syndrome, 4 and X-linked chronic granulomatous disease. 5,6 In addition to selection of the safest effective vector, the time frame and intensity of patient conditioning after stem cell harvest but before infusion of gene-corrected autologous stem cells requires thoughtful planning and discussion.…”

mentioning

confidence: 99%

UGT2B17 as a disease accelerator in CLL

Zhong

Byrd

2013

Blood

View full text Add to dashboard Cite

“…Parent steroids and metabolites are usually measured by gas chromatography/combustion/isotoperatio mass spectrometry (IRMS) and associated techniques. These assays are best performed in dedicated laboratories, accredited by international antidoping agencies (56,57 ). Steroid profiles, as determined routinely in doping control, provide essential information for several purposes because they are recorded and stored incrementally, with each collected drug-testing sample.…”

Section: Implications For Antidopingmentioning

confidence: 99%

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Musrap

Diamandis

2016

Clinical Chemistry

View full text Add to dashboard Cite

BACKGROUND Since its discovery in the 1970s, prostate-specific antigen (PSA) has become widely known as a biomarker of prostate cancer in males but has often been overlooked in female malignancies. Although the serum concentration of PSA differs between men and women by about 1000-fold, studies have suggested that PSA concentrations drastically differ among healthy females and those who exhibit increased androgen production. CONTENT There have been reports of increased PSA expression in women exhibiting hyperandrogenic states, including polycystic ovary syndrome and hirsutism, as well as marked increases in a subset of breast cancer patients. These findings have not only revealed the remarkable diagnostic potential of PSA in a diverse range of clinical conditions but also point to its potential of becoming a useful biomarker of steroid hormone doping among female athletes. Recently, highly sensitive assays that can measure PSA at low limits of detection have been developed, which will aid in the discrimination of PSA between these different conditions. SUMMARY The overall aim of this review is to revisit the expression of PSA in hormonally-regulated tissues and in female malignancies, and to demonstrate how the regulation of PSA permits its use in antidoping initiatives.

show abstract

Androgen Sulfation in Healthy UDP-Glucuronosyl Transferase 2B17 Enzyme-Deficient Men

Abstract: We propose that the androsterone glucuronide to epitestosterone glucuronide ratio may serve as a complementary biomarker to reveal testosterone abuse.

Cited by 35 publications

References 30 publications

Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

UGT2B17 as a disease accelerator in CLL

Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

Contact Info

Product

Resources

About