Androgen Synthesis in the Gonadotropin-Suppressed Human Testes Can Be Markedly Suppressed by Ketoconazole

Roth, Mara Y.; Nya-Ngatchou, Jean-Jacques; Lin, Kelvin; Page, Stephanie T.; Anawalt, Bradley D.; Matsumoto, Alvin M.; Marck, Brett T.; Bremner, William J.; Amory, John K.

doi:10.1210/jc.2012-3527

Cited by 12 publications

(11 citation statements)

References 29 publications

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“…9,10 The high efficacy among Chinese men has also been replicated using monthly TU injections. Limited invasive studies measuring intratesticular testosterone (and DHT) suggest that the degree of depletion may not predict reliably complete suppression of sperm output [196][197][198][199] and that other noninvasive markers of endogenous Leydig cell function, such as circulating epitestosterone 200 or 17-hydroxyprogesterone 201 or nonsteroidal testicular products such as INSL3, 202,203 may be markers of intratesticular androgen depletion. 187,188 However, the reasons for within-and between-population differences in susceptibility to hormonally induced azoospermia remain largely unexplained.…”

Section: Steroidal Methodsmentioning

confidence: 99%

Male Contraception

Handelsman¹

2016

Endocrinology: Adult and Pediatric

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Section: Steroidal Methodsmentioning

confidence: 99%

Male Contraception

Handelsman¹

2016

Endocrinology: Adult and Pediatric

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“…Whether these considerations are relevant in humans is not directly known. If relevant, further suppression of intratesticular testosterone by direct inhibition of steroidogenesis may be required, and proof of principle in humans has been demonstrated using a nonspecific inhibitor of steroidogenesis 49 . Drugs which inhibit 17 beta-hydroxysteroid dehydrogenase type 3 enzyme, which catalyzes the final step of testosterone biosynthesis, would specifically reduce testicular steroidogenesis.…”

Section: 3 Optimizing Mhc To Increase the Rate And Extent Of Sperm Output Suppressionmentioning

confidence: 99%

Male hormonal contraception: hope and promise

Piotrowska

Wang

Swerdloff

et al. 2017

The Lancet Diabetes & Endocrinology

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Family planning is a shared responsibility, but currently available male-directed methods are either not easily reversible (vasectomy) or not sufficiently effective (condom). Despite this, approximately 20% of couples using a contraceptive method worldwide, and up to 80% in some countries, choose a male-directed method. Male hormonal contraception (MHC) is acceptable and highly effective, with perfect use failure rates of 0.6% (95% confidence interval 0.3–1.1%) provided sperm concentration are maintained below 1 M/mL. Upon cessation of MHC, sperm quality fully recovers in a predictable manner resulting in pregnancies and live births. Spontaneous miscarriage and fetal malformation rates overlap that observed in the general population. Short-term adverse events, namely acne, night sweats, increased weight and altered mood and libido are recognized, but are generally mild. Further optimization of specific androgen-progestin regimens followed by Phase 3 studies of lead combinations is still required for successful development of an approved MHC and to determine long term adverse effects.

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“…Esetleges szerepük az azoospermia indukciójának gyorsításában merülhet fel [11], de egy TE és DMPA kombinációval végzett tanulmány során a kezelés kiegészítése a GnRHantagonista acyclinnel nem gyorsította a spermiogenezis gátlását és nem javította a spermium-célkoncentrációt elérő résztvevők arányát [36]. A GnRH-antagonisták használata egyelőre a klinikai kutatásokban való felhasználásra korlátozódik [38], bár új, per os alkalmazható hatóanyagok esetleg szerepet kaphatnak valamilyen fogamzásgátló kombinációban [11].…”

Section: Gnrh Agonisták-antagonistákunclassified

Férfi hormonális fogamzásgátlás: múlt, jelen, jövő

et al. 2017

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In certain regions of the world the enormous rate of population growth raises economic and public health concerns and widely accessible contraceptive methods would be desired. In contrast, in other countries the use of effective contraception is a question of individual preferences. Today, most of the reliable contraceptive methods are applied by women, while the options for male methods are quite limited. It is well known that significant portion of pregnancies are still unplanned and several data revealed men's willingness to take part in family planning. Based on these needs, remarkable efforts have been made to develop a suitable hormonal contraceptive agent for men. With the exogenous suppression of follicle stimulating hormone and luteinizing hormone secretion, the inhibition of the testicular testosterone production and the spermatogenesis can be achieved. In the beginning, testosterone-derivatives, or testosterone-progestin combinations were administered, later synthetic androgen agents were developed. Despite of these efforts, unfortunately, there is no safe, widely feasible male hormonal contraception to date, but in the future this goal can be achieved by solving the key hurdles. Orv Hetil. 2017; 158(46): 1819-1830.

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Androgen Synthesis in the Gonadotropin-Suppressed Human Testes Can Be Markedly Suppressed by Ketoconazole

Cited by 12 publications

References 29 publications

Male Contraception

Male Contraception

Male hormonal contraception: hope and promise

Férfi hormonális fogamzásgátlás: múlt, jelen, jövő

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