1981
DOI: 10.3109/01485018108999301
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Androgen Transport Proteins: Physical Properties, Hormonal Regulation, and Possible Mechanism of TeBG and ABP Action

Abstract: The physical properties and hormonal regulation of testosterone estradiol binding globulin (TeBG) and androgen binding protein (ABP) are reviewed. Brief mention is made of prostatic binding protein. The discussion focuses on the mechanism of action for these proteins in androgen secretion, transport, and absorption and androgen binding models. Speculations are presented for the functional significance of these proteins.

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Cited by 39 publications
(8 citation statements)
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“…The seatrout SBP demonstrated high specificity for estrogens and androgens and low binding of C 2 l steroids, somewhat similar to the binding specificity of other teleosts and primates including humans [24,26,57]. Earlier studies with humans suggested that there may be separate estrogen and androgen binding proteins [58]; however, further study demonstrated that a single protein bound both steroids [59]. In the seatrout, the comigration of testosterone and estradiol-173 binding activity under native PAGE and the ability of estrogens to displace labeled testosterone in the specificity studies suggest that a single protein binds both steroids in this species as well.…”
Section: Discussionmentioning
confidence: 63%
“…The seatrout SBP demonstrated high specificity for estrogens and androgens and low binding of C 2 l steroids, somewhat similar to the binding specificity of other teleosts and primates including humans [24,26,57]. Earlier studies with humans suggested that there may be separate estrogen and androgen binding proteins [58]; however, further study demonstrated that a single protein bound both steroids [59]. In the seatrout, the comigration of testosterone and estradiol-173 binding activity under native PAGE and the ability of estrogens to displace labeled testosterone in the specificity studies suggest that a single protein binds both steroids in this species as well.…”
Section: Discussionmentioning
confidence: 63%
“…Further studies will be necessary to account for these observations and to delineate the precise role of SBP in this context. Two structurally related plasma binding proteins for sex hormones have been described in males: (1) SBP which is synthesized in the liver and is present at relatively high concentrations in plasma and (2) androgen-binding protein (ABP) which is produced by the Sertoli cells of the testes and is present in high concentrations in tubular fluid but is also present in plasma at low concentrations relative to SBP (Bardin, Musto, Gunsalus, Kotite, Cheng, Larrea & Becker, 1981;Lobi, 1981). The protein being measured in the present study and referred to as SBP is probably not ABP of testicular origin since it is present in relatively high concentrations in plasma and has also been identified, at similarly high concentrations in the plasma of female Myotis (A. W. Gustafson & D. A. Damassa, unpublished observations).…”
Section: Discussionmentioning
confidence: 98%
“…Shimazaki et al [27] have reported the binding affinities of five compounds relative to R 1881 in BPH nuclear extract, obtaining results similar to those presented here. In human prostate cytosol, specificity data of androgen receptors for various substances in comparison with R 1881 also appear to be similar to those in the present work [28, 291. The specificity of the binding of various steroids to SHBG, in comparison with testosterone, has recently been summarized in a review article [30]. From the data presented, it is possible to calculate that the binding affinity relative to Sa-DHT has been reported to be between 33 to 100 % for testosterone, and between 12 to 33 % for estradiol.…”
Section: Characterization Of Nuclear Androgen Receptormentioning
confidence: 99%