Androgenetic alopecia and coronary artery disease in women

Mansouri, Parvin; Mortazavi, Seyed Mohammad Reza; Eslami, Mohammad; Mazinani, Mona

doi:10.5070/d38525g87b

Cited by 47 publications

(17 citation statements)

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“…Their study was carried out in 106 women under age 55 years who underwent coronary arteriography to diagnose CAD. The correlation of androgenetic alopecia and CAD, androgenetic alopecia, a previous history of myocardial infarction, and greying of hair and CAD were statistically significant after adjustment of data for differences in age [18]. In our research, demonstrated that CAD might be increased in patients with baldness, but the severity of CAD does not increase in this patient.…”

Section: Discussionmentioning

confidence: 39%

“…However, some other studies showed no association, but these did not control for CAD risk factors [14][15][16]. The results of the two cohort studies [17,18] were inconclusive. In 2001, Rebora et al [17] reviewed 24 articles in the literature from 1954 to 1999, as provided by MEDLINE.…”

Section: Discussionmentioning

confidence: 99%

“…Subjects who develop baldness before their 30s may have a higher risk for CAD than other men, and there may be individuals with early-onset androgenetic alopecia who also present with unusually elevated dihydrotestosterone-testosterone ratios. Interestingly, Mansouri et al [18] found that an association between androgenetic alopecia and CAD in women. Their study was carried out in 106 women under age 55 years who underwent coronary arteriography to diagnose CAD.…”

Section: Discussionmentioning

confidence: 99%

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Association of Baldness with Coronary Artery Disease and Its Severity

Arefi,

Pishgahi,

Joharimoghaddam

et al. 2020

GMJ

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Background: The pivotal role of baldness as a potential risk factor for cardiovascular disorders remains a debate, and the small body of literature has generated inconsistent findings. We aimed to assess the association between baldness and the risk for coronary artery disease (CAD) and its severity in a sample of Iranian men. Materials and Methods: This cross-sectional study was performed on 105 consecutive patients suspected to CAD and scheduled for elective coronary angiography. The severity of CAD was determined according to the number of involved coronary vessels. For assessing the severity of baldness, the Hamilton-Norwood scale for grading of androgenetic alopecia in males was used. Results: The overall frequency of CAD in the groups with and without baldness was 88.9% and 72.5%, respectively, indicating a significant difference (P=0.033). Similarly, patients with the family history of baldness suffered more from CAD as compared to those without history (93.3% vs.76.0%). However, no significant association was found between the baldness and non-baldness groups with regard to the severity of CAD (P=0.291). According to the multivariable logistic regression model, the presence of baldness could predict the increased likelihood of CAD (or=3.037, P=0.046). Conclusion: Along with traditional risk factors for CAD, the presence of baldness and positive family history of this phenotype could be considered as the primary determinant for the increasing likelihood of CAD. [GMJ.2020;9:e1474]

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Section: Discussionmentioning

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of Baldness with Coronary Artery Disease and Its Severity

Arefi,

Pishgahi,

Joharimoghaddam

et al. 2020

GMJ

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“…20 Thus, based on this premise, higher blood pressure (BP) has been found in both men and women with AGA when compared to controls. [21][22][23][24][25] The two predominant theories of the association between AGA and elevated BP involve androgens, pathogenic in AGA, binding to mineralocorticoid receptors, thus elevating BP; or hyperaldosteronism directly playing a role in AGA, which has been observed in murine models. 23 For example, Arias-Santiago et al found both significantly higher BP values and aldosterone levels in male and female AGA patients.…”

Section: Androgenetic Alopecia (Aga)mentioning

confidence: 99%

“…Hyperaldosteronism is implicated as a key player in the pathogenesis of essential and resistant hypertension and spironolactone, a mineralocorticoid receptor antagonist, is commonly used to treat AGA in women 20 . Thus, based on this premise, higher blood pressure (BP) has been found in both men and women with AGA when compared to controls 21–25 . The two predominant theories of the association between AGA and elevated BP involve androgens, pathogenic in AGA, binding to mineralocorticoid receptors, thus elevating BP; or hyperaldosteronism directly playing a role in AGA, which has been observed in murine models 23 .…”

Section: Nonscarring Alopeciasmentioning

confidence: 99%

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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Cardiovascular Disease, Insulin Resistance, Metabolic Syndrome, and AGA/FPHL

Anastassakis¹

2022

Androgenetic Alopecia From a to Z

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Androgenetic alopecia and coronary artery disease in women

Cited by 47 publications

References 0 publications

Association of Baldness with Coronary Artery Disease and Its Severity

Association of Baldness with Coronary Artery Disease and Its Severity

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Cardiovascular Disease, Insulin Resistance, Metabolic Syndrome, and AGA/FPHL

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