Androgenetic alopecia as an early marker of benign prostatic hyperplasia

Arias‐Santiago, Salvador; Arrabal-Polo, Miguel Ángel; Buendía‐Eisman, A.; Arrabal‐Martín, Miguel; Gutiérrez-Salmerón, María Teresa; Girón-Prieto, María Sierra; Jiménez-Pacheco, Antonio; Calonje, Jaime Eduardo; Naranjo‐Sintes, Ramón; Zuluaga-Gomez, Armando; Ortega, Salvio Serrano

doi:10.1016/j.jaad.2010.12.023

Cited by 39 publications

(33 citation statements)

References 44 publications

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“…Secondly, Habuchi et al [24] indicated that the BsmI polymorphism in the vitamin D receptor (VDR) gene plays a significant role in protection against BPH. A review finished by Adorini et al [25] demonstrate that VDR agonists, and notably to explain the increase in cardiovascular risk [26]. Interestingly, some studies suggest that BPH is associated with abdominal obesity [27], insulin levels, diabetes, hypertension [28], and systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Zhang

Zheng

Wang

et al. 2016

Urology

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Zhang

Zheng

Wang

et al. 2016

Urology

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“…A team of trained urologists collected data on a structured datasheet assessing age, use of medications, presence of previously diagnosed comorbidities e hypertension (defined as blood presure !130 Â 85 mm Hg or antihypertensive drug use), type 2 diabetes mellitus (defined as fasting plasma glucose !100 mg/dL or diabetes drug use), dyslipidemia (serum high-density lipoprotein <40 mg/dL, triglycerides !150 mg/dL, or lipid medication use), previous cardiovascular events, or previous urologic diagnoses and presence of LUTS with the International Prostate Symptom Score (IPSS) questionnaire. Presence of LUTS was categorized according to the IPSS as mild or asymptomatic (IPSS 0-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), or severe (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Presence of clinically significant LUTS was defined as a score equal to or greater than 8 on IPSS.…”

Section: Data Collectionmentioning

confidence: 99%

“…However, existing results are not only controversial but also limited by small cohorts, nonstandardized definitions of LUTS, and lack of control of confounding variables. [19][20][21][22] The objective of this study was to evaluate the association of cardiovascular risk factors and male LUTS for the first time in a Latin American population. A secondary objective was to evaluate a possible association between LUTS and AGA by multivariate analysis on a large cohort.…”

mentioning

confidence: 99%

Risk Factors for Male Lower Urinary Tract Symptoms: The Role of Metabolic Syndrome and Androgenetic Alopecia in a Latin American Population

Barbosa

Muracca

Nakano

et al. 2013

Urology

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“…Numerous studies have documented the association of androgenetic alopecia (AGA) with cancers,[12] coronary artery disease,[3] diabetes,[34] hypertension,[5] and metabolic syndrome (MetS). [678]…”

Section: Introductionmentioning

confidence: 99%

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

Chakrabarty

Hariharan²,

Gowda

et al. 2014

Int J Trichol

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Context:Although evidences for association of androgenetic alopecia (AGA) with metabolic syndrome (MetS) are accruing, inconclusiveness with respect to the gender specificity and differential association of MetS with increasing severity of AGA continues to persist. Furthermore, data specific to Indian settings are relatively sparse.Aims:The present study aimed at assessing the frequency of MetS in individuals with early AGA in Indian settings.Settings and Design:A case-control study was conducted at a trichology clinic in Bengaluru between April 2012 and September 2012 with a total of 85 cases of AGA and 85 age-matched controls.Materials and Methods:The Norwood-Hamilton classification was used to assess the grade of AGA. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, lipid parameters, and body mass index along with anthropometric measurements were assessed in all study participants.Statistical Analysis Used:Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test.Results:MetS was seen in a higher proportion of patients with AGA (43.5%) as compared to the control group (2.4%) and the differences were statistically significant (P < 0.001). As compared to controls, patients with AGA had higher triglycerides (P < 0.001), systolic blood pressure (P < 0.001), diastolic blood pressure (P < 0.001) along with significantly lower high-density lipoprotein cholesterol levels (P < 0.001). Severity of AGA was not associated with MetS.Conclusions:AGA is associated with MetS in male Indian patients aged <30 years. Studies with large sample sizes may be required to conclusively define any putative associations between AGA grades and MetS.

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Androgenetic alopecia as an early marker of benign prostatic hyperplasia

Cited by 39 publications

References 44 publications

Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

Risk Factors for Male Lower Urinary Tract Symptoms: The Role of Metabolic Syndrome and Androgenetic Alopecia in a Latin American Population

Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population

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