Androgenic Modulation of Lipid Metabolism at Subcellular Sites in Cholestatic Rats

Hossain, Al Amin; Hornick, Conrad A.

doi:10.1055/s-2007-1000766

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Even with significant increases in FT and DHT, this furthers indicates that 6-OXO supplemented at these dosages for eight weeks did not decrease fat mass or cause an anabolic response by increasing muscle mass. Increased serum androgens levels have been shown to stimulate lipolysis due to increases in the activity of hormone sensitive lipase [ 21 ]; however, relative to the dosage and/or the duration of ingestion of 6-OXO on serum androgens in the present study, neither had any effect on body composition. In our previous study, eight weeks of supplementation with 72 mg/day of the nutritional aromatase inhibitor Novedex XT had no effect on fat-free mass, but was effective at producing a modest, but significant 3.5% decrease in fat mass when compared to placebo [ 16 ].…”

Section: Discussioncontrasting

confidence: 84%

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Rohle

Wilborn

Taylor

et al. 2007

Journal of the International Society of Sports Nutrition

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The purpose of this study was to determine the effects of 6-OXO, a purported nutritional aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and clinical safety markers in resistance trained males. Sixteen males were supplemented with either 300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Blood and urine samples were obtained at weeks 0, 1, 3, 8, and 11 (after a 3-week washout period). Blood samples were analyzed for total testosterone (TT), free testosterone (FT), dihydrotestosterone (DHT), estradiol, estriol, estrone, SHBG, leutinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), cortisol, FT/estradiol (T/E). Blood and urine were also analyzed for clinical chemistry markers. Data were analyzed with two-way MANOVA. For all of the serum hormones, there were no significant differences between groups (p > 0.05). Compared to baseline, free testosterone underwent overall increases of 90% for 300 mg 6-OXO and 84% for 600 mg, respectively (p < 0.05). DHT underwent significant overall increases (p < 0.05) of 192% and 265% with 300 mg and 600 mg, respectively. T/E increased 53% and 67% for 300 mg and 600 mg 6-OXO, respectively. For estrone, 300 mg produced an overall increase of 22%, whereas 600 mg caused a 52% increase (p < 0.05). Body composition did not change with supplementation (p > 0.05) and clinical safety markers were not adversely affected with ingestion of either supplement dose (p > 0.05). While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.

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Section: Discussioncontrasting

confidence: 84%

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Rohle

Wilborn

Taylor

et al. 2007

Journal of the International Society of Sports Nutrition

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“…Increased serum androgen concentrations related to hypergonadism can accelerate lipolysis via activation of hormone-sensitive lipase (Hossain & Hornick, 1994), while a state of hypogonadism is correlated with a diminished fat-oxidation efficiency and a subsequent reduction in resting energy expenditure (Hayes, 2000). We observed significant increases in total and bioavailable testosterone levels, without any noticeable change in estradiol between AI and PL, thus indicating a possible connection between increased androgen levels and decreased fat mass, even though no markers of lipolysis were assessed.…”

Section: Discussionmentioning

confidence: 67%

Effects of a Purported Aromatase and 5 α-Reductase Inhibitor on Hormone Profiles in College-Age Men

Wilborn

Taylor²,

Poole³

et al. 2010

International Journal of Sport Nutrition and Exercise Metabolism

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The purpose of this study was to determine the effects of an alleged aromatase and 5-α reductase inhibitor (AI) on strength, body composition, and hormonal profiles in resistance-trained men. Thirty resistance-trained men were randomly assigned in a double-blind manner to ingest 500 mg of either a placebo (PL) or AI once per day for 8 wk. Participants participated in a 4-d/wk resistance-training program for 8 wk. At Weeks 0, 4, and 8, body composition, 1-repetition-maximum (1RM) bench press and leg press, muscle endurance, anaerobic power, and hormonal profiles were assessed. Statistical analyses used a 2-way ANOVA with repeated measures for all criterion variables (p ≤ .05). Significant Group × Time interaction effects occurred over the 8-wk period for percent body fat (AI: -1.77% ± 1.52%, PL: -0.55% ± 1.72%; p = .048), total testosterone (AI: 0.97 ± 2.67 ng/ml, PL: -2.10 ± 3.75 ng/ml; p = .018), and bioavailable testosterone (AI: 1.32 ± 3.45 ng/ml, PL: -1.69 ± 3.94 ng/ml; p = .049). Significant main effects for time (p ≤ .05) were noted for bench- and leg-press 1RM, lean body mass, and estradiol. No significant changes were detected among groups for Wingate peak or mean power, total body weight, dihydrotestosterone, hemodynamic variables, or clinical safety data (p > .05). The authors concluded that 500 mg of dailyAI supplementation significantly affected percent body fat, total testosterone, and bioavailable testosterone compared with a placebo in a double-blind fashion.

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“…This decrease in fat mass was further verified by an effect size of 0.60. Increased androgens associated with hypergonadism have been shown to stimulate lipolysis because of increases in the activity of hormone-sensitive lipase (10) and to also increase heat production in brown adipose tissue because of the increased expression of uncoupling protein-3 (5). On the other hand, hypogonadism is known to be associated with less-efficient fat oxidation and a concomitant decrease in the resting energy expenditure, which is the likely reason that this condition is associated with increases in adiposity and decreases in fat-free mass.…”

Section: Weekmentioning

confidence: 99%

Eight Weeks of Aromatase Inhibition Using the Nutritional Supplement Novedex XT: Effects in Young, Eugonadal Men

Willoughby

Wilborn²,

Taylor³

et al. 2007

International Journal of Sport Nutrition and Exercise Metabolism

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This study examined the effects of an aromatase-inhibiting nutritional supplement on serum steroid hormones, body composition, and clinical safety markers. Sixteen eugonadal young men ingested either Novedex XT or a placebo daily for 8 wk, followed by a 3-wk washout period. Body composition was assessed and blood and urine samples obtained at weeks 0, 4, 8, and 11. Data were analyzed by 2-way repeated-measures ANOVA. Novedex XT resulted in average increases of 283%, 625%, 566%, and 438% for total testosterone (P=0.001), free testosterone (P=0.001), dihydrotestosterone (P=0.001), and the testosterone:estrogen ratio (P=0.001), respectively, whereas fat mass decreased 3.5% (P=0.026) during supplementation. No significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones (P>0.05). This study indicates that Novedex XT significantly increases serum androgen levels and decreases fat mass.

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Androgenic Modulation of Lipid Metabolism at Subcellular Sites in Cholestatic Rats

Cited by 7 publications

References 20 publications

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Effects of a Purported Aromatase and 5 α-Reductase Inhibitor on Hormone Profiles in College-Age Men

Eight Weeks of Aromatase Inhibition Using the Nutritional Supplement Novedex XT: Effects in Young, Eugonadal Men

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