Androgenic steroids dysregulation and the risk of coronary artery disease

Joury, Abdulaziz; Alshehri, Mona G.; Li, Luke Z; Rezan, Tameem

doi:10.1080/14779072.2022.2077193

Cited by 2 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low levels of testosterone were found to be related to an increased risk for CAD [ 52 , 53 ]. Despite some studies showing a relationship between the serum levels of steroids and an increased risk of CAD [ 54 , 55 , 56 ], there was no established direct connection between pregnenediol sulfate and atherosclerotic vascular disease until recently.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Profiling of Stages of Coronary Artery Disease Progression

Anlar,

Anwardeen,

Al Ashmar

et al. 2024

Metabolites

View full text Add to dashboard Cite

Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are key contributors to CAD development. Metabolomics, with its comprehensive analysis of metabolites, offers a unique perspective on cardiovascular diseases. This study leveraged metabolomics profiling to investigate the progression of CAD, focusing on the interplay of hypercholesterolemia, hypertension, and diabetes. We performed a metabolomic analysis on 221 participants from four different groups: (I) healthy individuals, (II) individuals with hypercholesterolemia (HC), (III) individuals with both HC and hypertension (HT) or diabetes, and (IV) patients with self-reported coronary artery disease (CAD). Utilizing data from the Qatar Biobank, we combined clinical information, metabolomic profiling, and statistical analyses to identify key metabolites associated with CAD risk. Our data identified distinct metabolite profiles across the study groups, indicating changes in carbohydrate and lipid metabolism linked to CAD risk. Specifically, levels of mannitol/sorbitol, mannose, glucose, and ribitol increased, while pregnenediol sulfate, oleoylcarnitine, and quinolinate decreased with higher CAD risk. These findings suggest a significant role of sugar, steroid, and fatty acid metabolism in CAD progression and point to the need for further research on the correlation between quinolinate levels and CAD risk, potentially guiding targeted treatments for atherosclerosis. This study provides novel insights into the metabolomic changes associated with CAD progression, emphasizing the potential of metabolites as predictive biomarkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolomics Profiling of Stages of Coronary Artery Disease Progression

Anlar,

Anwardeen,

Al Ashmar

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

“…Comprehensive and extended analytical retrospectivity for AASs have been subject of continued research, but also advanced means facilitating the differentiation of natural and endogenously produced steroids from synthetic substances as well as enhancing the understanding of metabolic pathways depending on drug amounts or application routes. 102 In the light of the considerable health risks associated with AASs, both physically [38][39][40][41][42][43] and psychologically, [44][45][46] detection and containment in recreational as well as elite sport remains critical. 103 Here, the utility of luteinizing hormone (LH) was revisited and reported to represent a sensitive marker for current androgen abuse, 47 which, in concert with established targeted testing approaches, can contribute further insights into the prevalence and misuse of steroidal substances.…”

Section: Anabolic Agentsmentioning

confidence: 99%

Annual banned‐substance review—Analytical approaches in human sports drug testing 2021/2022–

Thevis

Kuuranne

Geyer

2022

Drug Testing and Analysis

View full text Add to dashboard Cite

Also in 2021/2022, considerable efforts were invested into advancing human sports drug testing programs, recognizing and taking into account existing as well as emerging challenges in anti-doping, especially with regard to substances and methods of doping specified in the World Anti-Doping Agency's 2022 Prohibited List. In this edition of the annual banned-substance review, literature on recent developments published between October 2021 and September 2022 is summarized and discussed.Focus is put particularly on enhanced analytical approaches and complementary testing options in human doping controls, appreciating the exigence and mission in anti-doping and, equally, the contemporary "new normal" considering, for example, the athlete's exposome versus analytical sensitivity and applicable anti-doping regulations for result interpretation and management.

show abstract

Androgenic steroids dysregulation and the risk of coronary artery disease

Cited by 2 publications

References 55 publications

Metabolomics Profiling of Stages of Coronary Artery Disease Progression

Metabolomics Profiling of Stages of Coronary Artery Disease Progression

Annual banned‐substance review—Analytical approaches in human sports drug testing 2021/2022–

Contact Info

Product

Resources

About