Androgenicity and venous endothelial function in post-menopausal women

Maturana, Maria Augusta; Rubira, Marcelo Custódio; Consolim‐Colombo, Fernanda Marciano; Irigoyen, Maria Cláudia; Spritzer, Poli Mara

doi:10.1007/bf03345786

Cited by 7 publications

(3 citation statements)

References 55 publications

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“…4 Mild increases of free testosterone, even within normal limits, have been associated with changes in endothelial function in healthy postmenopausal women. 4,30 In the present series, SHBG was significantly lower in women with METS and in those who were obese. This is in accordance with other reports indicating that SHBG levels positively correlate with HDL-C values and inversely to glucose (fasting and postprandial) and insulin levels.…”

Section: Discussionmentioning

confidence: 80%

Obesity is Related to Increased Menopausal Symptoms among Spanish Women

Fernández-Alonso

Cuadros

Chedraui³

et al. 2010

Menopause International

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Section: Discussionmentioning

confidence: 80%

Obesity is Related to Increased Menopausal Symptoms among Spanish Women

Fernández-Alonso

Cuadros

Chedraui³

et al. 2010

Menopause International

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“…These changes include the cessation of ovarian estrogen secretion, changes in several CV risk factors such as body fat distribution [26,27], hypertension [28], and adverse changes in lipid profile [29] and endothelial and autonomic function [30,31], as well as the metabolic syndrome and insulin resistance [32].…”

Section: Discussionmentioning

confidence: 99%

Subclinical cardiovascular disease in postmenopausal women with low/medium cardiovascular risk by the Framingham risk score

et al. 2015

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“…In the same study, there was no significant relationship of endogenous androgens with coronary calcification (39). In a small study on 26 postmenopausal women, FAI was positively related to acetylcholine doses for maximal vasodilation, a surrogate marker of early endothelial dysfunction (46) Current literature, in its majority, suggests a favorable role of endogenous estrogens and an adverse role of androgens on the vasculature. However, there is a substantial body of clinical studies showing no significant association of endogenous sex steroids with early atherosclerotic changes, implying that if a role of endogenous estrogen and androgen levels in the atherosclerotic process is finally confirmed, its magnitude is modest.…”

Section: Early Markers Of Atherosclerosismentioning

confidence: 90%

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Παππά

Alevizaki

2012

European Journal of Endocrinology

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Objective: Cardio-and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio-and cerebro-vascular disease in the postmenopausal period. Design and methods: We performed a PubMed search using the terms 'endogenous estrogen', 'androgen', 'cardiovascular disease', 'cerebro-vascular disease', 'stroke', 'carotid artery disease', and 'subclinical atherosclerosis'. Results: The majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive. Conclusions: Most studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio-and cerebro-vascular disease remains an interesting field of future research.

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Androgenicity and venous endothelial function in post-menopausal women

Abstract: This study suggests that FAI, even within normal limits, is related to early changes in endothelial function in healthy post-menopausal women. Longitudinal studies are required to determine the clinical relevance of these findings.

Cited by 7 publications

References 55 publications

Obesity is Related to Increased Menopausal Symptoms among Spanish Women

Obesity is Related to Increased Menopausal Symptoms among Spanish Women

Subclinical cardiovascular disease in postmenopausal women with low/medium cardiovascular risk by the Framingham risk score

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

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