Androgens and ageing of the skin

Makrantonaki, Evgenia; Zouboulis, Christos C.

doi:10.1097/med.0b013e32832b71dc

Cited by 56 publications

(42 citation statements)

References 59 publications

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“…ACCEPTED MANUSCRIPT (Makrantonaki and Zouboulis, 2007a) and hormones (Makrantonaki et al, 2008;Makrantonaki and Zouboulis, 2009;Zouboulis et al, 2007;Zouboulis Ch, 2003).…”

Section: Skin Ageingmentioning

confidence: 99%

“…One of the key enzymes, cytochrome P450c17, which is necessary for synthesis of dehydroepiandrosterone and androstenedione, has been documented to be expressed in human sebocytes. These androgenic pro-hormones can be further converted by sebocytes and sweat glands, and probably also by dermal papilla hair cells, into more potent androgens, such as testosterone and 5α-DHT (Makrantonaki and Zouboulis, 2009;Zouboulis et al, 2007). In addition, the enzyme aromatase may convert testosterone and androstenedione to estrogens in sebaceous glands, outer as well as inner root sheath cells of anagen terminal hair follicles, and dermal papilla cells (Fritsch et al, 2001;Thornton et al, 2006).…”

Section: Sex Steroidsmentioning

confidence: 99%

“…It is not by coincidence that elderly males show a slower healing process in comparison with their age-matched female counterparts (Makrantonaki and Zouboulis, 2009). …”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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“…ACCEPTED MANUSCRIPT (Makrantonaki and Zouboulis, 2007a) and hormones (Makrantonaki et al, 2008;Makrantonaki and Zouboulis, 2009;Zouboulis et al, 2007;Zouboulis Ch, 2003).…”

Section: Skin Ageingmentioning

confidence: 99%

Section: Sex Steroidsmentioning

confidence: 99%

See 1 more Smart Citation

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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“…The deficiency of these hormones leads to dryness, wrinkling, epidermal atrophy, collagen breakdown and loss of elasticity 15 .…”

Section: Hormonal Levelsmentioning

confidence: 99%

Untitled

2014

Hygeia.J.D.Med.

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“…Estrogen deficiency directly affects skin homeostasis [3] and may also result in dysregulation of peripheral androgen metabolism. Androgens have been documented to influence skin morphology and play a distinguished role in epidermal barrier homeostasis, wound healing, sebaceous gland growth, differentiation and hair growth [4]. …”

Section: Introductionmentioning

confidence: 99%

Acne Tarda and Male-Pattern Baldness Unmasking Primary Ovarian Insufficiency: A Case and Review

Zouboulis

Achenbach²,

Makrantonaki

2014

Dermatology

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A 30-year-old woman presented with recurrent acne lesions and progressing male-pattern baldness. Furthermore, she reported amenorrhea, weight loss, mucosal xerosis and dyspareunia since discontinuation of hormonal contraception 6 months earlier in order to conceive. Acne tarda and androgenetic alopecia of female pattern were diagnosed. Hormonal and immunologic serological and ultrasound examinations revealed an autoimmune hypergonadotropic primary ovarian insufficiency (POI) with no ovarian cysts but ovarian fibrosis with marked reduced follicle pool. Immediate ovarian stimulation and in vitro fertilization led to pregnancy and the patient gave birth to a healthy child. Though presenting with clinical findings similar to menopause, 50% of patients with POI exhibit varying and unpredictable ovarian function, and only 5-10% are able to accomplish pregnancy. Genetic disorders affect the X chromosome. In 14-30% of cases POI has been associated with autoimmunity. POI may occur after discontinuation of hormonal contraception, like in our case.

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Androgens and ageing of the skin

Cited by 56 publications

References 59 publications

Skin and brain age together: The role of hormones in the ageing process

Skin and brain age together: The role of hormones in the ageing process

Untitled

Acne Tarda and Male-Pattern Baldness Unmasking Primary Ovarian Insufficiency: A Case and Review

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