2007
DOI: 10.1016/j.jsbmb.2006.11.019
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Androgens and androgen receptors in breast cancer

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Cited by 96 publications
(52 citation statements)
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References 100 publications
(146 reference statements)
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“…The exact role of androgen in breast cancer development, prognosis and therapy has been in the center of significant controversies; this is partly due to different applied methodologies, with their focus on different androgen molecules and different groups of patients [2]. Some studies have identified significant correlations between high testosterone levels and breast cancer development in pre-menopausal women.…”
Section: Introductionmentioning
confidence: 99%
“…The exact role of androgen in breast cancer development, prognosis and therapy has been in the center of significant controversies; this is partly due to different applied methodologies, with their focus on different androgen molecules and different groups of patients [2]. Some studies have identified significant correlations between high testosterone levels and breast cancer development in pre-menopausal women.…”
Section: Introductionmentioning
confidence: 99%
“…In women, sex steroid hormones are produced by the ovaries (and adrenal glands in the case of androgens) and through peripheral conversion of circulating precursors (Simpson 2003, Nicolas Diaz-Chico et al 2007, McNamara et al 2014, McNamara & Sasano 2015. SSRs are structurally related and evolutionarily conserved, have similar consensus DNA-binding motifs and use common co-factors for activity (Germain et al 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, a characteristic steroid receptor expression profile further defines these tumors as consistently estrogen receptor (ER) negative, progesterone receptor (PR) negative and androgen receptor (AR) positive. [4][5][6][7][8] Although AR expression has been variably observed in up to 60-70% breast carcinomas, 9,10 consistent AR expression tends to be a feature of apocrine breast lesions including invasive apocrine carcinomas. 4,5,8,11,12 Moreover, recently published gene expression microarray studies defined a characteristic 'molecular apocrine' gene expression profile found in apocrine carcinomas.…”
mentioning
confidence: 99%