Androgens and <scp>COVID</scp>‐19

Das, Kinnor; Patil, Anant; Goren, Andy; Cockerell, Clay J.; Goldust, Mohamad

doi:10.1111/jocd.15090

Cited by 7 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 22 ] The regulation of androgens and their receptors (AR) are important factors modulating the severity of COVID-19. [ 23 ] Moreover, the expression of AR plays a role in the development of type 2 diabetes and insulin resistance. [ 24 ] The phosphorylation of the N protein produced by SARS-CoV-2 by glycogen synthase kinase 3 (GSK3) is required for its function, while the inhibition of GSK3B impairs its phosphorylation, viral transcription, and replication.…”

Section: Discussionmentioning

confidence: 99%

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review

Li,

Zhou,

Wang

et al. 2023

Medicine

View full text Add to dashboard Cite

To explore the potential mechanism of Gegen Qinlian decoction (GGQL) in the treatment of COVID-19 comorbid with diabetes mellitus (DM) through network pharmacology and molecular docking, and to provide theoretical guidance for clinical transformation research. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to screen the active compounds and targets of GGQL, the targets of COVID-19 comorbid with DM were searched based on Genecards database. Protein-protein interaction network was constructed using String data platform for the intersection of compounds and disease targets, the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of the intersection targets was performed using DAVID database. Cytoscape software was used to construct the “compound target-pathway (C-T-P)” of GGQL in the treatment of COVID-19 comorbid with DM, the molecular docking platform was used to complete the simulated docking of key compounds and targets. We obtained 141 compounds from GGQL, revealed 127 bioactive compounds and 283 potential targets of GGQL. Quercetin, kaempferol and formononetin in GGQL play a role by modulating the targets (including AR, GSK3B, DPP4, F2, and NOS3). GGQL might affect diverse signaling pathways related to the pathogenesis of coronavirus disease – COVID-19, AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, human cytomegalovirus infection and Th17 cell differentiation. Meanwhile, molecular docking showed that the selected GGQL core active components had strong binding activity with the key targets. This study revealed that GGQL play a role in the treatment of COVID-19 comorbid with DM through multi-component, multi-target and multi-pathway mode of action, which provided good theoretical basis for further verification research.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review

Li,

Zhou,

Wang

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…In some European countries such as Italy and Germany, patients affected with COVID-19 subjects showed lower testosterone patients admitted to ICU. This research outcome shows a link between the androgen levels in the blood and androgen sensitivity [ 116 ]. From some point of view, a factor causes SARS-CoV-2 inflammation.…”

Section: Sars-cov-2 Infection and Male Infertilitymentioning

confidence: 99%

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

et al. 2023

View full text Add to dashboard Cite

COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. SARS-CoV-2 may be transmitted sexually, according to preliminary research. Testicular cells exhibit a high level of the angiotensin-converting enzyme 2 (ACE2) receptor, which enhances the entry of the SARS-CoV-2 into host cells. Some instances of COVID-19 have been documented to exhibit hypogonadism during the acute stage. Furthermore, systemic inflammatory reactions triggered by SARS-CoV-2 infection may cause oxidative stress (OS), which has been shown to have profoundly deleterious consequences on testicular functioning. This work gives a clear picture of how COVID-19 may affect male reproductive systems and calls attention to the many unanswered questions about the mechanisms by which this virus can be linked to men’s health and fertility.

show abstract

“…Baghani [11]. Данные предположения могут объяснить как низкий уровень смертности среди детей препубертатного возраста, так и гендерные различия в заболевании COVID-19 [40].…”

Section: андрогенетическая алопеция и Covid-19unclassified

The association of hair loss and coronavirus infection COVID-19 – facts and hypotheses

et al. 2023

View full text Add to dashboard Cite

The main manifestations of COVID-19 are primarily interstitial pneumonia and respiratory failure. No less than 20% of patients have variable skin rashes, which try to be interpreted as markers and predictors of the peculiarities of the course of coronavirus infection. In addition, hair loss is a characteristic manifestation of COVID-19, and the salivary follicles are regarded as a target for SARS-CoV-2. The most common variants of alopecia in patients with a new coronavirus infection or vaccine-induced alopecia are acute telogenic, nondescript, and androgenetic alopecia. This review provides information on the most common variants of hair loss in patients with SARS-CoV-2 infection, the features of their manifestations, and possible mechanisms of development. Acute telogenic hair loss is the most common variant of SARS-CoV-2-induced alopecia, is characteristic of patients with subacute course of COVID-19 and can be combined with trichodynia, anosmia and aguvia, which are markers of nervous syste damage. Given the variability in the time of onset after infection, a heterogeneous pathogenesis of alopecia can be assumed. Nested alopecia after COVID-19 is often a relapse of the disease, its severity and frequency do not correlate with the severity of the infectious disease, and its prevalence in women indicates the importance of hormonal factors in its development. Androgenetic alopecia may be a predictor of high risk of infection, severe course, and recurrence of COVID-19. The first two variants of alopecia may be associated with COVID-19 vaccination, and the latter is a predictor of inadequate immune response to vaccine administration. The mechanisms of the damaging effects of SARS-CoV-2 on hair follicles have not been fully deciphered and are most likely complex, with different leading links in different types of hair loss. Deciphering these mechanisms may provide prerequisites for understanding the mechanisms of COVID-19 damage to other tissues and organs.

show abstract

Androgens and COVID‐19

Cited by 7 publications

References 36 publications

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

The association of hair loss and coronavirus infection COVID-19 – facts and hypotheses

Contact Info

Product

Resources

About