Androgens in maternal vascular and placental function: implications for preeclampsia pathogenesis

Kumar, Sathish; Gordon, Geoffrey H.; Abbott, David H.; Mishra, Jay S.

doi:10.1530/rep-18-0278

Cited by 89 publications

(89 citation statements)

References 157 publications

(209 reference statements)

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“…The relationship between androgens and maternal cardiovascular and placental function deserves particular consideration because the serum T level in women with preeclampsia is elevated and correlates with vascular dysfunction [5]. Our finding of elevated serum T in women with preeclampsia supports previous studies, thus suggesting that increased androgens and androgen signaling may contribute to preeclampsia [5,11,12].…”

Section: Discussionsupporting

confidence: 87%

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Levels of sex steroid hormones and their receptors in women with preeclampsia

Lan

Lai

Cheng

et al. 2020

Reprod Biol Endocrinol

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Background: Pregnant women have high serum concentrations of sex steroid hormones, which are major regulators of paracrine and autocrine responses for many maternal and placental functions. The main purpose of this study was to compare patients with preeclampsia and patients with uncomplicated pregnancies in terms of serum steroid hormones (estradiol [E2], progesterone [P4], dehydroepiandrosterone sulfate [DHEAS], and testosterone [T]) throughout pregnancy and the levels of cord blood and placental steroid receptors during the third trimester. Methods: Quantitative real-time reverse transcription PCR, western blotting, and immunohistochemistry were used to determine the levels of steroid hormones in the serum and cord blood and the placental levels of estrogen receptor-α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Results: There were 45 women in the uncomplicated pregnancy group and 30 women in the preeclampsia group. Serum levels of T were greater and serum levels of E2 were reduced in the preeclampsia group, but the two groups had similar levels of P4 and DHEAS during the third trimester. Cord blood had a decreased level of DHEAS in the preeclampsia group, but the two groups had similar levels of P4, E2, and T. The two groups had similar placental mRNA levels of ERα, ERβ, AR, and PR, but the preeclampsia group had a higher level of ERβ protein and a lower level of ERα protein. Immunohistochemistry indicated that the preeclampsia group had a greater level of ERβ in the nucleus and cytoplasm of syncytiotrophoblasts and stromal cells.Conclusions: Women with preeclampsia had lower levels of steroid hormones, estrogen, and ERα but higher levels of T and ERβ. These molecules may have roles in the pathogenesis of preeclampsia.

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Section: Discussionsupporting

confidence: 87%

“…Androgens have the opposite effect. Previous studies have compared the serum levels of sex steroid hormones and signaling in women who had preeclampsia with women who had uncomplicated pregnancies [4][5][6][7]. Unsurprisingly, women with preeclampsia exhibited altered serum concentrations of sex steroid hormones.…”

Section: Introductionmentioning

confidence: 99%

Levels of sex steroid hormones and their receptors in women with preeclampsia

Lan

Lai

Cheng

et al. 2020

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 86%

Levels of sex steroid hormones and their receptors in women with preeclampsia

Lan

Lai

Cheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Pregnant women have high serum concentrations of sex steroid hormones, which are major regulators of paracrine and autocrine responses for many maternal and placental functions. The main purpose of this study was to compare patients with preeclampsia and patients with uncomplicated pregnancies in terms of serum steroid hormones (estradiol [E2], progesterone [P4], dehydroepiandrosterone sulfate [DHEAS], and testosterone [T]) throughout pregnancy and the levels of cord blood and placental steroid receptors during the third trimester. Methods: Quantitative real-time reverse transcription PCR, western blotting, and immunohistochemistry were used to determine the levels of steroid hormones in the serum and cord blood and the placental levels of estrogen receptor-α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Results: There were 45 women in the uncomplicated pregnancy group and 30 women in the preeclampsia group. Serum levels of T were greater and serum levels of E2 were reduced in the preeclampsia group, but the two groups had similar levels of P4 and DHEAS during the third trimester. Cord blood had a decreased level of DHEAS in the preeclampsia group, but the two groups had similar levels of P4, E2, and T. The two groups had similar placental mRNA levels of ERα, ERβ, AR, and PR, but the preeclampsia group had a higher level of ERβ protein and a lower level of ERα protein. Immunohistochemistry indicated that the preeclampsia group had a greater level of ERβ in the nucleus and cytoplasm of syncytiotrophoblasts and stromal cells. Conclusions: Women with preeclampsia had lower levels of steroid hormones, estrogen, and ERα but higher levels of T and ERβ. These molecules may have roles in the pathogenesis of preeclampsia.

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“…Hormonal dysregulation, antenatal depression and/or chronic stress lead to changes in hypothalamic pituitary adrenal axis (HPA) function. This results in stimulation of high cortisol production and release that can restrict flow of nutrients and oxygen to the fetus [97][98][99][100]. Antenatal depression may also affect maternal immune system function via glucocorticoid hormone imbalance that may increase susceptibility to various microbial infections [101][102][103][104] and poor fetal growth.…”

Section: Discussionmentioning

confidence: 99%

Global burden of antenatal depression and its association with adverse birth outcomes: an umbrella review

et al. 2020

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Background: Women of childbearing age are at high risk of developing depression and antenatal depression is one of the most common mood disorders. Antenatal depression is also associated with a number of poor maternal and infant outcomes, however, there remains a lack of focus on mental issues in antenatal care, particularly in lower income countries. This systematic review of reviews provides useful evidence regarding the burden of antenatal depression which may provide guidance for health policy development and planning. Methods: We searched CINAHL(EBSCO), MEDLINE (via Ovid), PsycINFO, Emcare, PubMed, Psychiatry Online, and Scopus databases for systematic reviews that based on observational studies that were published in between January 1st, 2007 and August 31st, 2018. We used the Assessment of Multiple Systematic Reviews (AMSTAR) checklist scores to assess the quality of the included reviews. We applied vote counting and narrative review to summarize the prevalence of antenatal depression and its associated factors, while statistical pooling was conducted for estimating the association of antenatal depression with low birth weight and preterm birth. This systematic review of reviews was registered on PROSPERO with protocol number CRD42018116267. Results: We have included ten reviews (306 studies with 877,246 participants) on antenatal depression prevalence and six reviews (39 studies with 75,451 participants) conducted to identify the effect of antenatal depression on preterm and low birth weight. Globally, we found that antenatal depression prevalence ranged from 15 to 65%. We identified the following prominent risk factors based on their degree of influence: Current or previous exposure to different forms of abuse and violence (six reviews and 73 studies); lack of social and/or partner support (four reviews and 47 studies); personal or family history of any common mental disorder (three reviews and 34 studies). The risk of low birth weight and preterm birth was 1.49 (95%CI: 1.32, 1.68; I 2 = 0.0%) and 1.40 (95%CI: 1.16, 1.69; I 2 = 35.2%) times higher among infants born from depressed mothers. Conclusions: Globally, antenatal depression prevalence was high and could be considered a common mental disorder during pregnancy. Though the association between antenatal depression and adverse birth outcomes appeared to be modest, its absolute impact would be significant in lower-income countries with a high prevalence of antenatal depression and poor access to quality mental health services.

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Androgens in maternal vascular and placental function: implications for preeclampsia pathogenesis

Cited by 89 publications

References 157 publications

Levels of sex steroid hormones and their receptors in women with preeclampsia

Levels of sex steroid hormones and their receptors in women with preeclampsia

Levels of sex steroid hormones and their receptors in women with preeclampsia

Global burden of antenatal depression and its association with adverse birth outcomes: an umbrella review

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