Androgens regulate mitochondrial cytochrome <i>c</i> oxidase and lysosomal hydrolases in mouse skeletal muscle

Koenig, Harold; Goldstone, Alfred; Lu, C Y

doi:10.1042/bj1920349

Cited by 37 publications

(19 citation statements)

References 21 publications

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“…In rodents, androgens have been shown to up-regulate CO expression in several tissues, including kidney, epididymis, aorta, and skeletal muscle (Koenig et al, 1980;Goldstone et al, 1981;Cornwall et al, 1992). Both HVc and RA express androgen receptors (Arnold et al, 1976;Balthazart et al, 1992;Brenowitz and Arnold, 1992;Smith et al, 1996), so T could exert a direct effect on the amount or activity of the CO enzyme in these areas.…”

Section: Discussionmentioning

confidence: 97%

Testosterone treatment increases the metabolic capacity of adult avian song control nuclei

2001

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In songbirds, the size of brain nuclei that control song learning and production change seasonally. These changes are mainly controlled by seasonal changes in plasma testosterone (T) concentration. One hypothesis to explain why it may be adaptive for these areas to regress in the fall is that this would decrease the metabolic demand of maintaining a large song system when singing is reduced or absent. We used a marker for cellular metabolism to examine birds with regressed song nuclei and compared them to birds whose song nuclei were induced to grow by administration of exogenous T. Photorefractory male Gambel's white-crowned sparrows were captured during their autumnal migration and kept in outdoor aviaries on a natural photoperiod. We implanted birds with Silastic capsules containing T or with empty implants. Three weeks later the birds were sacrificed. We assayed the brains for cytochrome oxidase (CO) activity and measured the volume of four song nuclei: HVc, RA, 1MAN, and area X. All four nuclei increased in volume in response to T treatment. T treatment increased the metabolic capacity of area X, HVc, and RA relative to surrounding tissue but had no effect on the metabolic capacity of 1MAN. These results support the hypothesis that song nuclei are more metabolically active under the influence of T than they are when plasma T levels are low.

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Section: Discussionmentioning

confidence: 97%

Testosterone treatment increases the metabolic capacity of adult avian song control nuclei

2001

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“…According to data obtained in a murine model (23), the BGLU activity of a male muscle homogenate was higher than that of females. This difference tended to disappear after orchidectomy and reappeared when the orchidectomized mice received testosterone.…”

Section: Discussionmentioning

confidence: 99%

Serum hexosaminidase and ß-glucuronidase activities in infants: effects of age and sex

Mabe

Beck

2003

Braz J Med Biol Res

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We investigated the effect of age and sex on the serum activity of hexosaminidase (HEX) and ß-glucuronidase (BGLU) in 275 normal term infants aged 12 h to 12 months. Up to six weeks of life, HEX was significantly higher in boys (P£0.023). During the age period of 1-26 weeks, BGLU was also higher in boys, but differences were significant only at 2-6 and 7-15 weeks (P£0.016). The developmental pattern of HEX and BGLU was sex dependent. HEX activity increased in both sexes from 4-7 days of life, reaching a maximum of 1.4-fold the birth value at 2-6 weeks of age in boys (P<0.001) and a maximum of 1.6-fold at 7-15 weeks in girls (P<0.001). HEX activity gradually decreased thereafter, reaching significantly lower levels at 27-53 weeks than during the first three days of life in boys (P = 0.002) and the same level of this age interval in girls. BGLU increased in both sexes from 4-7 days of age, showing a maximum increase at 7-15 weeks (3.3-fold in boys and 2.9-fold in girls, both P<0.001). Then BGLU decreased in boys to a value similar to that observed at 4-7 days of age. In girls, BGLU remained elevated until the end of the first year of life. These results indicate a variation of HEX and BGLU activities during the first year of life and a sex influence on their developmental pattern. This observation should be considered in the diagnosis of GM 2 gangliosidosis and mucopolysaccharidosis type VII.

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“…In laboratory rats and mice, there is some evidence to suggest that systemic androgen treatment can affect mitochondria and/or oxidative metabolism. In mice, androgen-dependent sex differences exist in cytochrome oxidase c activity (Koenig et al 1980), and indices of oxidative capacity are positively correlated with circulating testosterone (Pitteloud et al 2005). More direct evidence comes from studies of genetic manipulation of AR in myocytes.…”

Section: Mitochondriamentioning

confidence: 98%

Subcellular effects of myocyte-specific androgen receptor overexpression in mice

Musa

Fernando

Chatterjee

et al. 2011

Journal of Endocrinology

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Although androgen receptor (AR) within myocytes is thought to mediate many of the effects of testosterone and other androgens on skeletal muscle, little is known about the functions of AR within these cells. We, therefore, studied the ultrastructure of skeletal muscle of HSA-AR transgenic (Tg) mice that overexpress AR selectively in myocytes and exhibit neuromuscular atrophy. We examined male HSA-AR mice from two different founding lines: L78 (lower copy number and less severe phenotype) and L141 (higher copy number and more severe phenotype) and compared these to wild-type (Wt) brothers. We also examined testosterone-treated female mice from these two lines and compared them both to their Wt sisters and to vehicle-treated controls. Ultrastructural examination of extensor digitorum longus sections using transmission electron microscopy revealed remarkably disorganized myofibrils in male Tg and testosterone-treated female Tg mice. Quantification of ultrastructural pathology indicated reduced myofibril width, hypertrophic and hyperplastic intermyofibrillar mitochondria, and pronounced glycogen accumulation in HSA-AR males of both lines. Reduced myofibrillar width and increases in mitochondrial number, size, and volume density were also observed in testosterone-treated HSA-AR females, although glycogen accumulation was not observed. Structural abnormalities in mitochondria were also associated with increases in electron transport chain activity and systemic resting metabolic rate, indicative of hypermetabolism. We find that overexpression of AR in myocytes of HSA-AR mice results in alterations in myofibrils, mitochondria, and glycogen. Alterations in myofibrils and mitochondria appear to result from acute actions of testosterone, whereas those on glycogen do not. Pathology of myofibrils and/or mitochondria may, therefore, mediate in part the neuromuscular atrophy observed in HSA-AR mice.

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Androgens regulate mitochondrial cytochrome c oxidase and lysosomal hydrolases in mouse skeletal muscle

Cited by 37 publications

References 21 publications

Testosterone treatment increases the metabolic capacity of adult avian song control nuclei

Testosterone treatment increases the metabolic capacity of adult avian song control nuclei

Serum hexosaminidase and ß-glucuronidase activities in infants: effects of age and sex

Subcellular effects of myocyte-specific androgen receptor overexpression in mice

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