Andrographolide: A Review of its Anti-inflammatory Activity via Inhibition of NF-kappaB Activation from Computational Chemistry Aspects

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

“…1) exhibit an enhanced ability to induce apoptosis and G1 cell-cycle arrest in breast and colon cancer cells (25,27). Other studies have shown that AGP interferes with MAPK activation, increases sensitivity of Ras-transformed cells to radiation treatment in vitro and in vivo (27)(28)(29)(30), and is not toxic (31). The drug-like (32) AGP has three hydrogen-bond donors and five acceptors and a LogP of 2.6.…”

“…2. Pocket 1 comprises the effector binding loop (residues [30][31][32][33][34][35][36][37][38][39][40], β2 (residues 55 and 57), and several residues in α-helix 1. Pocket 2 involves the core β-strands 1 and 2, part of the effector loop, and switch 2.…”

Evaluation of anti–bacterial and anti–oxidant potential of andrographolide and echiodinin isolated from callus culture of Andrographis paniculata Nees

“…The in vitro antibacterial and antifungal assays were carried out by adopting the micro-dilution techniques according to the National Committee for Clinical Laboratory Standards procedures for aerobic testing. Briefly, each of the microbes tested were sub-cultured twice on Mueller-Hinton agar, and the colonies (5)(6)(7) were then transferred aseptically into individual tubes containing sterile nutrient broth (10 mL). The tubes were incubated for a period of 8-12 h at 37 °C to attain growth at log phase.…”

“…It is a popular ethno-medicinal herb used for treating infection, inflammation, cold, fever, snake bite, diarrhoea, dysentery, jaundice, kidney diseases, and anti-oxidant agent [3] . Previous phytochemical studies on A. paniculata Nees has resulted in isolation of flavonoids and andrographolides (AND) [4] , and various parts of this plant have been reported to possess multiple therapeutic properties including anti-cancer [5] , antidiabetes [6] , anti-inflammatory [7] , anti-malarial, antipyretic, anti-typhoid, antiviral, hepatoprotective [8] , antihuman immunodeficiency virus and immunostimulatory activity [9] .…”

Antifungal Activity of Andrographolide Compound Extracted From Andrographis Paniculata

“…In addition, in some cases fungi are indirectly responsible for allergic or toxic disorders among consumers because of the production of mycotoxins or allergens. Extensive research prevailed that Andrographis paniculata has broad range of pharmacologic effects such anti-inflammatory 12,13 , antimalarial 10 , Cardiovascular and anti-inflammatory activities 7,3 .…”