Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway

Lee, Ko-Chen; Chang, Hen‐Hong; Chung, Ying-Hui; Lee, Tzung-Yan

doi:10.1016/j.jep.2011.03.068

Cited by 124 publications

(68 citation statements)

References 38 publications

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“…They suggested that the anti-tumor effect of andrographolide could partly be attributed to its apoptotic and anti-inflammatory potential during DMBA induced hamster buccal pouch carcinogenesis. Also, previous studies demonstrated the apoptotic and anti-inflammatory potential of andrographolide in various cancer cells (Cheung et al, 2005;Lee et al, 2011;. It has been demonstrated that andrographolide suppressed VEGF expression in prostate cancer and pulmonary tumors (Zhao et al, 2008).…”

Section: Discussionmentioning

confidence: 91%

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Singh

Manoharan²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 91%

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Singh

Manoharan²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Moreover, inflammation is a crucial process in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (Heneka and O'Banion, 2007), Parkinson's disease (Kim and Joh, 2006), and multiple sclerosis (Rock and Peterson, 2006). In general, microglia play an important role in neuroprotection, especially confrontation with pathogens from the external environment; however, overexpression of microglia causes many key cellular responses that can cause diseases by inducing pro-inflammatory mediators such as NO, PGE 2 and TNF-α (Lee et al, 2011). Therefore, a promising therapeutic strategy used for neurodegenerative diseases was focused on blocking microglial activation processes (Kim and Joh, 2006;Yuan et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Endoplasmic Reticulum Stress and NF-κB Pathway in Salidroside Mediated Neuroprotection: Potential of Salidroside in Neurodegenerative Diseases

Wang

Lou

et al. 2017

Am. J. Chin. Med.

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Microglial activation leads to increased production of proinflammatory enzymes and cytokines, which is considered to play crucial role in neurodegenerative diseases, however there are only a few drugs that target microglia activation. Recent studies have indicated that the Traditional Chinese Medicine, salidroside (Sal), exerted anti-inflammatory effects. According to this evidence, our present study aims to explore the effect of the Sal (a phenylpropanoid glycoside compound which is isolated from rhodiola), on microglia activation in lipopolysaccharide (LPS)-stimulated BV-2 cells. Our results showed that Sal could significantly inhibit the excessive production of Nitric Oxide (NO) and Prostaglandin E2 (PGE 2 ) in LPS-stimulated BV2 cells. Moreover, Sal treatment could suppress the mRNA and protein expressions of inflammatory enzymes, including Inducible Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2). The mechanisms may be related to the inhibition of the activation of Nuclear Factor-kappaB (NF-κB) and endoplasmic reticulum stress. Our study demonstrated that salidroside could inhibit lipopolysaccharide-induced microglia The American Journal of Chinese Medicine, Vol. 45, No. 7, 1459-1475 © 2017 activation via the inhibition of the NF-κB pathway and endoplasmic reticulum stress, which makes it a promising therapeutic agent for human neurodegenerative diseases.

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“…Previous studies have found that AG exhibits potent anti-inflammatory activity. [53][54][55] However, the therapeutic application of AG is restricted by its low solubility in water, which results in low bioavailability after oral administration. The oral bioavailability of AG was improved by the optimized AG-NE developed in this study and the anti-inflammatory potential of AG-NE was further proven.…”

mentioning

confidence: 99%

Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

Yen

Chen

et al. 2018

IJN

110

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Background Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflammatory bowel disease. Methods A high-pressure homogenization technique was used to prepare the AG-NE and solubility, viscosity, and droplet size tests were conducted to develop the optimized AG-NE composed of α-tocopherol, ethanol, Cremophor EL, and water. The permeability was assessed using everted rat gut sac method and in vivo absorption and anti-inflammatory effect in rats was also evaluated. The plasma concentration of AG was determined using our validated high performance liquid chromatography method, which was used to generate a linear calibration curve over the concentration range of 0.1–25 μg/mL in rat plasma ( R 2 >0.999). Results The optimized AG-NE had a droplet size of 122±11 nm confirmed using transmission electron microscopy and a viscosity of 28 centipoise (cps). It was stable at 4 and 25°C for 90 days. An ex vitro intestinal permeability study indicated that the jejunum was the optimal site for AG absorption from the optimized AG-NE, which was 8.21 and 1.40 times higher than that from an AG suspension and AG ethanol solution, respectively. The pharmacokinetic results indicate that the absorption of AG from AG-NE was significantly enhanced in comparison with that from the AG suspension, with a relative bioavailability of 594.3%. Moreover, the ulcer index and histological damage score of mice with indomethacin-induced intestinal lesions were significantly reduced by AG-NE pretreatment. Conclusion We conclude that the developed AG-NE not only enhanced the oral bioavailability of AG in this study but may also prove to be an effective formulation of AG for preventing gastrointestinal inflammatory disorders.

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Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway

Cited by 124 publications

References 38 publications

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Endoplasmic Reticulum Stress and NF-κB Pathway in Salidroside Mediated Neuroprotection: Potential of Salidroside in Neurodegenerative Diseases

Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

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