Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, &lt;i&gt;in Vitro&lt;/i&gt; and &lt;i&gt;in Vivo&lt;/i&gt; Evaluation

Zou, Linghui; Ding, Wenya; Huang, Qiuyan; Yang, Xu; Li, Jilang; Huang, Tianyan; Li, Zeyu; Lin, Si; Jiao, Feng

doi:10.1248/bpb.b22-00154

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…XYP injection is a mixture of andrographolide sulfate made from andrographolide extracted from Andrographis Herba through sulfonation reaction to increase water solubility, bioavailability, and stability ( Loureiro Damasceno et al, 2022 ; Zou et al, 2022 ). Andrographolide is the main component of XYP injection.…”

Section: Resultsmentioning

confidence: 99%

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach

Shen

Guo

et al. 2022

Front. Pharmacol.

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Graphical AbstractA dual in vitro mitochondrial toxicity assay approach combing the conventional “glucose/galactose” assay in HepG2 cells with the cytotoxic assay in mitochondrial respiration deficient cells was established in this study. Using this platform, we systematically assessed the mitochondrial toxicity of TCM injections for the first time. Four TCM injections were identified with potential mitochondrial toxicity. Their toxic ingredients were predicted by molecular docking and validated by the dual in vitro approach.

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Section: Resultsmentioning

confidence: 99%

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach

Shen

Guo

et al. 2022

Front. Pharmacol.

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“…It forms complexes that retain poorly soluble molecules within its hydrophobic interior, while the exterior of the complex remains hydrophilic, thereby enhancing solubility (Zou et al. 2022 ); and (3) piperine, a bioenhancer that increases bioavailability (Dudhatra et al. 2012 ), leading to increased pharmacological efficacy of the active compound.…”

Section: Discussionmentioning

confidence: 99%

“…To develop the combination formulation, two main kinds of solubilizing agents were used in this study [β-cyclodextrin (Zou et al. 2022 ) and sodium dodecyl sulfate (SDS) (Bahr et al. 2019 )].…”

Section: Methodsmentioning

confidence: 99%

Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs

Songvut,

Boonyarattanasoonthorn,

Nuengchamnong

et al. 2024

Pharmaceutical Biology

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Context The therapeutic potential of andrographolide is hindered by its poor oral bioavailability and unpredictable pharmacokinetics, primarily due to its limited water solubility. Objective This work aimed to enhance the solubility and pharmacokinetics of andrographolide, a bioactive compound in Andrographis paniculata (Burm. f.) Nees (Acanthaceae), using solubilizing agents and a bioenhancer. Materials and methods Four groups of beagles were compared: (1) A. paniculata powder alone (control), (2) A. paniculata powder with 50% weight/weight (w/w) β-cyclodextrin solubilizer, (3) A. paniculata powder with 1% w/w sodium dodecyl sulfate (SDS) solubilizer, and (4) A. paniculata powder co-administered with 1% w/w SDS solubilizer and 10% piperine bioenhancer. All groups received a consistent oral dose of 3 mg/kg of andrographolide, administered both as a single dose and multiple doses over seven consecutive days. Results Thirteen chemical compounds were identified in A. paniculata powder, including 7 diterpenoids, 5 flavonoids, and 1 phenolic compound. A. paniculata co-administration with either 50% w/w β-cyclodextrin or 1% w/w SDS, alone or in combination with 10% w/w piperine, significantly increased systemic andrographolide exposure by enhancing bioavailability (131.01% to 196.05%) following single and multiple oral co-administration. Glucuronidation is one possible biotransformation pathway for andrographolide, as evidenced by the excretion of glucuronide conjugates in urine and feces. Conclusion The combination of solubilizing agents and a bioenhancer improved the oral bioavailability and pharmacokinetics of andrographolide, indicating potential implications for A. paniculata formulations and clinical therapeutic benefits. Further investigation in clinical studies is warranted.

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“…Although marker compounds of many natural products have been identified, this does not mean that they are biologically active compounds, and there are some compounds with low bioavailability ( Ministry of Food and Drug Safety, 2021 ). Compounds with low bioavailability can be considered in combination with carriers that increase bioavailability ( Parveen et al, 2022 ; Zou et al, 2022 ). There was a study conducted on resistant cancer cell lines, which shows the possibility of natural products to overcome the drug resistance in cancer ( Han et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of natural products in combination with anticancer agents in prostate cancer: A scoping review

Cheon

2022

Front. Pharmacol.

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Background: Prostate cancer is the second most common cancer in men and has the fourth highest mortality among men worldwide. Different combination therapies for cancer are being tested, and among them, the integration of natural products is increasing. This study reviews research on the combination of anticancer drugs and natural products for the treatment of prostate cancer and suggests future directions in this field.Methods: Articles were identified by searching the PubMed, Embase, and Cochrane Library databases. Search keywords included the following: “Antineoplastic agents,” “Anticancer drug,” “Phytotherapy,” “Natural product,” “Drug synergism,” and “Synergistic effect”. The selection process focused on whether the differences in efficacy of anticancer drugs were evaluated when combined with natural products.Results: Nineteen studies were included. All 19 studies evaluated efficacy in vitro, as well as 10 in vivo. There were 13 studies on a single compound extracted from natural products, three studies on mushroom and herb extracts, and three studies on herbal medicines consisting of three herbs, and a dietary supplement containing 10 herbs. Cancer cell lines used were PC-3 in nine studies, LNCaP in six studies, C4-2 in five studies, DU-145 in four studies, and 22Rv1 in two studies. Anti-cancer drugs co-administered were as follows: docetaxel in nine studies, doxorubicin and enzalutamide in three studies, paclitaxel and suberoylanilide hydroxamic acid in two studies, and cisplatin, vincristine, and bicalutamide in one study each.Conclusion: Although prostate cancer is prevalent worldwide, there are relatively few studies on the use of natural products with anticancer agents as treatment. Since it has reported that the efficacy of anticancer drugs is enhanced by coadministration of natural products, it is necessary to conduct further studies on this.

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Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, <i>in Vitro</i> and <i>in Vivo</i> Evaluation

Cited by 9 publications

References 50 publications

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach

Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs

Synergistic effects of natural products in combination with anticancer agents in prostate cancer: A scoping review

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