Andrographolide production and enhanced antioxidant activity in Andrographis paniculata (Burm f.) Nees. promoted by seaweed liquid extracts

Uthirapandi, Veeranan; Subramanian, S.; Ponnerulan, Boomibalagan; Saminathan, Eswaran; Narayanan, Vijayanand; Kathiresan, Durairaj

doi:10.1007/s40415-021-00715-x

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…A. paniculata has been used for centuries in traditional Asian medicines for the treatment of diarrhea, malaria, flu, leptospirosis, leprosy, rabies, syphilis, upper respiratory infections, sinusitis, HIV infection, and tuberculosis [ 28 , 29 , 30 , 31 ].…”

Section: Occurrence and Chemistry Of The Labdane Diterpenoid Androgra...mentioning

confidence: 99%

Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

Tundis

Patra

Bonesi

et al. 2023

Plants

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In spite of the progress in treatment strategies, cancer remains a major cause of death worldwide. Therefore, the main challenge should be the early diagnosis of cancer and the design of an optimal therapeutic strategy to increase the patient’s life expectancy as well as the continuation of the search for increasingly active and selective molecules for the treatment of different forms of cancer. In the recent decades, research in the field of natural compounds has increasingly shifted towards advanced and molecular level understandings, thus leading to the development of potent anti-cancer agents. Among them is the diterpene lactone andrographolide, isolated from Andrographis paniculata (Burm.f.) Wall. ex Nees that showed shows a plethora of biological activities, including not only anti-cancer activity, but also anti-inflammatory, anti-viral, anti-bacterial, neuroprotective, hepatoprotective, hypoglycemic, and immunomodulatory properties. Andrographolide has been shown to act as an anti-tumor drug by affecting specific molecular targets that play a part in the development and progression of several cancer types including breast, lung, colon, renal, and cervical cancer, as well as leukemia and hepatocarcinoma. This review comprehensively and systematically summarized the current research on the potential anti-cancer properties of andrographolide highlighting its mechanisms of action, pharmacokinetics, and potential side effects and discussing the future perspectives, challenges, and limitations of use.

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Section: Occurrence and Chemistry Of The Labdane Diterpenoid Androgra...mentioning

confidence: 99%

Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

Tundis

Patra

Bonesi

et al. 2023

Plants

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“…Hence, disparity of andrographolide content and antioxidant activity in products may be partly cause by using different part of the plant. Despite the fact that, there are several methods to determine andrographolide and antioxidant [6][7][8][9]. They are chemical involved, complicated and time consuming.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Andrographolide and Antioxidant Activities in Andrographis peniculata Commercial Products by Color Parameters

Petchpoung,

Soiklom,

Siri-Anusornsak

2024

Trends Sci

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Andrographis paniculata (Burm.f.) Wall.ex Nees is a standing out medicinal herb. It contains a large quantity of andrographolide and wildly used a traditional herb in many countries. Andrographolide is found in all part of the plant. However, those part are different in color, active compound content and antioxidant activity. Even though, there are several methods to determine andrographolide and antioxidant. They are chemical involved, complicated and time consuming. Therefore, the objective of this study was to develop estimation method of andrograhpholide content and antioxidant activities by CIE color parameters. The result showed that range of CIE color parameters of andrographolide sample were broad with range from light greyish yellow-green to greyish dark green. Antioxidant activity was barely correlated with colors. However, andrographolide content showed moderate correlation with colors. Dark green andrographis herb contain higher andrographolide than light greyish yellow-green one. Furthermore, andrographolide content could be numerical estimated by CIELab and CIELCh color parameters. The developed estimating method were easy, rapid and no chemical involved. HIGHLIGHTS Andrographolide content showed moderate correlation with colors Darker and greener andrographis herb was assumed that contain higher amount of andrographolide Andrographolide content could be numerical estimated by CIELab and CIELCh color parameters The estimating model were easy, rapid and no chemical involved GRAPHICAL ABSTRACT

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Andrographolide production and enhanced antioxidant activity in Andrographis paniculata (Burm f.) Nees. promoted by seaweed liquid extracts

Cited by 2 publications

References 46 publications

Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

Estimation of Andrographolide and Antioxidant Activities in Andrographis peniculata Commercial Products by Color Parameters

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