Androluteoma syndrome of pregnancy

Zander, J.; Mickan, H.; Holzmann, K; Lohe, K. J.

doi:10.1016/0002-9378(78)90362-9

Cited by 36 publications

(7 citation statements)

References 15 publications

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“…11 In 25% of cases, luteomas are hormonally active, with secretion of androgens, which can result in maternal hirsutism and virilization. 12 Virilization of the female fetus occurs in half the patients with maternal hirsutism, which results in clitoral enlargement and ambiguous genitalia. 9,13 Fetal sensitivity to maternal serum androgen depends on both the age at which exposure occurs and the ability of the placenta to aromatize androgens into estrogens.…”

Section: A B Cmentioning

confidence: 99%

Luteoma of pregnancy: sonographic findings in two cases.

Choi

Levine

Finberg

2000

Journal of Ultrasound in Medicine

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Luteoma of pregnancy is a rare nonneoplastic tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. It is usually asymptomatic and is found incidentally during a cesarean section or postpartum tubal ligation. However, luteomas can be hormonally active, with production of androgens resulting in maternal and fetal hirsutism and virilization. Less than 200 cases have been described in the literature, and none in radiologic journals. Recognition of this entity is important so that unnecessary oophorectomy, with concomitant risk to both the patient and the fetus, is avoided. In this report, we describe two cases of luteoma of pregnancy. The first case documents sequential ultrasonographic demonstration of a presumed luteoma of pregnancy in a patient who was seen with hirsutism during a second trimester pregnancy. The luteoma, serum androgen levels, and patient's condition improved after delivery. This case is unique in that although the mass significantly decreased in size post partum, it continued to be visualized 14 months post partum. The second case illustrates the pronounced cystic appearance that these classically described solid lesions can demonstrate because of extensive necrosis.

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Section: A B Cmentioning

confidence: 99%

Luteoma of pregnancy: sonographic findings in two cases.

Choi

Levine

Finberg

2000

Journal of Ultrasound in Medicine

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“…however, virilization has been caused by a pregnancy-related benign ovarian neoplasm, luteoma or androluteoma [20]. Here we present our own and 7 other cases, in which a bilateral ovarian hyperthecosis led to virili zation of a pregnant woman.…”

Section: Commentmentioning

confidence: 83%

“…Since 1930, approximately 50 cases of vir ilization associated with pregnancy have been described [3,4,7,9,12,14,20], Most of these were caused by a unilateral or bilateral ovarian tumor, and only few cases were with certainty due to bilateral hyperthecosis. Friedman et al [3] described a patient who developed virilization in both her pregnan cies.…”

Section: Commentmentioning

confidence: 99%

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Virilization during Pregnancy due to Bilateral Hyperthecosis

Erkkola¹,

Seppälä²,

Klemi³

1985

Horm Res

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A case of recurrent maternal virilization associated with bilateral hyperthecosis of the ovary during two pregnancies is described. In the first pregnancy, serum testosterone increased to the level of 12.5 nmol/l and in the second pregnancy to 35 nmol/l and after delivery to 66 nmol/l. 5 months after the second birth the testosterone level was 2.7 nmol/l and virilization had spontaneously regressed. Puerperal stimulation tests with human menopausal or with human chorionic gonadotropin did not increase ovarian androgen production. Female babies were not virilized.

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“…In 25% of the cases, luteomas are hormonally active leading to secretion of androgens causing maternal hirsutism and virilization. [5] Virilization of the female fetus occurs in half of the patients with maternal hirsutism, which results in clitoral enlargement and ambiguous genitalia. Male fetuses are not affected by this condition.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy luteoma: A rare case report

Verma

Paul

Chahal

et al. 2016

Int J App Basic Med Res

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Pregnancy luteomas are rare, nonneoplastic lesions of the ovary thought to be caused by the hormonal effects of pregnancy. Most of these patients are asymptomatic with the ovarian enlargement being incidentally discovered during imaging or surgery. Some patients develop hirsutism or virilization during late pregnancy. Luteomas spontaneously regress postpartum. It may be a diagnostic and management challenge as it can mimic the presentation of malignant ovarian tumors. We present a 33-year-old female with an enlarged ovary discovered incidentally at the time of cesarean section.

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Androluteoma syndrome of pregnancy

Cited by 36 publications

References 15 publications

Luteoma of pregnancy: sonographic findings in two cases.

Luteoma of pregnancy: sonographic findings in two cases.

Virilization during Pregnancy due to Bilateral Hyperthecosis

Pregnancy luteoma: A rare case report

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