Anechoic halo in solid liver tumors: sonographic, microangiographic, and histologic correlation.

Marchal, G; Pylyser, K; Tshibwabwa-Tumba, E; Verbeken, Eric; Oyen, Raymond; Baert, A L; Lauweryns, Joseph M.

doi:10.1148/radiology.156.2.2409569

Cited by 58 publications

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“…It is likely that the halo pattern is derived from certain histologic changes in the surrounding liver parenchyma compressed by the tumor. 16 Thus we conclude that ultrasonography is one of the useful modalities for differentiating between hepatocellular carcinoma and metastatic liver cancer. For this purpose, careful analysis of echo patterns should be made, including the internal echoes of tumor and external echoes associated with the tumor.…”

Section: Discussionmentioning

confidence: 73%

Ultrasonographic differentiation of hepatocellular carcinoma from metastatic liver cancer

Yoshida¹,

Matsue

Okazaki³

et al. 1987

J of Clinical Ultrasound

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Ultrasonographic features of tumor nodules in 64 patients with hepatocellular carcinoma and 87 with metastatic liver cancer were analyzed for differential diagnosis. Sonographic characteristics of hepatocellular carcinoma were the mosaic, posterior echo enhancement, and lateral shadow patterns, which were rarely observed in metastatic liver cancers. Small hepatocellular carcinomas, less than 3 cm in diameter, showed a hypoechoic pattern. Metastatic liver cancers originating from the gastrointestinal tract were frequently hyperechoic irrespective of their size and the bull's-eye-like pattern was specific for metastases from the lung. These results indicate that ultrasonography is useful for the differential diagnosis of hepatocellular carcinoma and metastatic liver cancer.

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Section: Discussionmentioning

confidence: 73%

Ultrasonographic differentiation of hepatocellular carcinoma from metastatic liver cancer

Yoshida¹,

Matsue

Okazaki³

et al. 1987

J of Clinical Ultrasound

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“…The architecture of the liver parenchyma is often changed by the presence of hepatic metastases leading to compression of hepatic parenchyma, inflammatory infiltrate, ductular transformation, and increased presence of immature hepatocytes. [25][26][27] It is known that immature hepatocytes often have impaired expression of their organic anion transporters, which are essential for the transport of many organic anions, including ICG. [28][29][30][31][32] For example, in the absence of multidrug resistance P-glycoprotein 2, the biliary excretion of ICG can be reduced by 90%.…”

Section: Discussionmentioning

confidence: 99%

Near‐infrared fluorescence‐guided resection of colorectal liver metastases

Vorst

Schaafsma

Hutteman

et al. 2013

Cancer

279

216

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BACKGROUND The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. Our objectives were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation. METHODS We exploited the high tissue penetration of near-infrared (NIR) light using the FLARE™ image-guided surgery system and the NIR fluorophore indocyanine green (ICG) in a clinical trial of 40 patients undergoing hepatic resection for colorectal cancer metastases. RESULTS A total of 71 superficially located (< 6.2 mm beneath the liver capsule) colorectal liver metastases were identified and resected using NIR fluorescence imaging. Median tumor-to-liver ratio (TLR) was 7.0 (range 1.9–18.7) and no significant differences between time-points or doses were found. ICG fluorescence was seen as a rim around the tumor, which we show to be entrapment around CK7-positive hepatocytes compressed by the tumor. Importantly, in 5 of 40 patients (12.5%, 95% CI: 5.0–26.6), additional small and superficially located lesions were detected using NIR fluorescence, and were otherwise undetectable by preoperative computed tomography (CT), intraoperative ultrasound (IOUS), visual inspection, and palpation. CONCLUSION We conclude that NIR fluorescence imaging, even when utilizing a non-targeted, clinically available NIR fluorophore, is complementary to conventional imaging and able to identify missed lesions by other modalities.

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“…The active tumour tissue is located in the periphery of the tumour and is often only a few mm thin border of the otherwise necrotic/fibrotic tumour (15). The needles were therefore aimed to hit the extreme periphery of the tumour so the risk of missing the tumour was substantial.…”

Section: Diagnostic Accuracy In Relation To Treatment Needle Size Anmentioning

confidence: 99%

“…The needles were therefore aimed to hit the extreme periphery of the tumour so the risk of missing the tumour was substantial. Some of the tumours had a hypoechoic peripheral zone from where the biopsy was taken because this is believed to be an active part of the tumour (15). On some of these occasions the pathology report showed normal liver and, on some, tumour.…”

Section: Diagnostic Accuracy In Relation To Treatment Needle Size Anmentioning

confidence: 99%

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Ultrasound-Guided Biopsies of Neuroendocrine Metastases

Elvin¹,

Wilander²,

Öberg³

et al. 1993

Acta Radiol

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Twenty-fivepatients with known neuroendocrine tumour disease were biopsied with 1.2 mm and 0.9 rom biopsy-gun needles to evaluate the respective diagnostic accuracy of the 2 needle sizes. The influence of treatment-related fibrosis on the histopathological diagnosis was also evaluated. The overall diagnostic accuracy with the 0.9 mm needle was 69% as compared to 92% with the 1.2 mm needle. This difference, however, seems more related to needle guiding difficulties with the 0.9 mm needle than to insufficient tissue yield. When the tumour was hit with both the 0.9 and the 1.2 mm needle the tissue yield was inferior with the 0.9 mm needle in only one of 16 cases. The increased amount of fibrous tissue due to interferon treatment did not seem to negatively influence the diagnostic accuracy.

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Anechoic halo in solid liver tumors: sonographic, microangiographic, and histologic correlation.

Cited by 58 publications

References 0 publications

Ultrasonographic differentiation of hepatocellular carcinoma from metastatic liver cancer

Ultrasonographic differentiation of hepatocellular carcinoma from metastatic liver cancer

Near‐infrared fluorescence‐guided resection of colorectal liver metastases

Ultrasound-Guided Biopsies of Neuroendocrine Metastases

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