Anemia

Cascio, Michael J.; DeLoughery, Thomas G.

doi:10.1016/j.mcna.2016.09.003

Cited by 72 publications

(27 citation statements)

References 14 publications

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“…During anemia of chronic infections, inflammations, and concurrent micronutrient deficiencies, iron stores are adequate, but there is impaired iron delivery to the developing red cell. As a result, the hemoglobin content of newly synthesized RBC will be decreased (hypochromic) [10]. However, normocytic hypochromic anemia was significantly lowered after supplementation, from 28/50 to 8/27.…”

Section: Discussionmentioning

confidence: 99%

“…This may due to either lack of specificity in MCV measurement or morphologic changes that occur over the time. As several possible factors can cause this morphologic abnormality, the morphologic of RBC can be changed as the causes are altered overtime [10]. Therefore, this may not be necessarily due to the effect of supplementation alone.…”

Section: Discussionmentioning

confidence: 99%

“…Normocytic anemia (MCV 80–100 fL) is majorly due to anemia of chronic infection and inflammation, multiple causes and hemolysis or blood loss. Based on underlying mechanism anemia is classified as hypo proliferative (decrease in RBC production) or maturation abnormalities (increase in RBC loss or destruction) [10–12]. …”

Section: Introductionmentioning

confidence: 99%

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Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia

et al. 2018

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ObjectiveTo characterize anemia and evaluate hematological responses to universal iron-folic acid (IFA) supplementation in Ethiopian pregnant women.MethodA hospital- based prospective follow up study was done between December 2016 and June 2017. Hematological profiles were measured in pregnant women before and after a minimum of one-month IFA supplementation. Mean values and abnormal proportions of hematological profiles were compared before and after supplementation using paired t-test and McNemar test, respectively. Univariate and multivariate analysis were used to analyze the association between independent variables and poor treatment responses.ResultLack of adequate hemoglobin response was found in 48.5%(95/196) of the participants. Prevalence of anemia and low hematocrit value were decreased significantly after IFA supplementation (p = 0.002, and p = 0.001, respectively). Normocytic hypochromic anemia was the commonest form of anemia found in this study followed by normocytic normochromic anemia. There was no statistically significant association between poor hemoglobin responses and all studied factors such as educational level, household size, parity, recent illness, stage of pregnancy, coffee consumption, and duration of iron treatment.ConclusionOur study revealed poor hemoglobin responses in nearly half of the study participants and a high proportion of anemias morphologically atypical of iron deficiency anemia. There is a need to consider anemia attributable to etiologies other than an iron deficiency in anemia intervention programs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia

et al. 2018

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“…Sustained hyperglycemia is shown to exacerbate cardiac damage through changes of erythrocyte [ 14 ]. Mean corpuscular volume (MCV) is the measure of the average size of erythrocytes, which is closely related to erythrocyte disorders [ 15 , 16 ]. It is reduced in diabetes, probably because iron deficiency anemia is common in people with diabetes [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Admission Mean Corpuscular Volume for Major Adverse Cardiovascular Events following Stent Implantation in Nondiabetic and Diabetic Patients with Acute Coronary Syndrome

et al. 2020

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Background. One of the key concerns of the clinician is to identify and manage risk factors for major adverse cardiovascular events (MACEs) in nondiabetic and diabetic patients with acute coronary syndrome (ACS) undergoing stent implantation. Mean corpuscular volume (MCV) is a marker of erythrocyte size and activity and is associated with prognosis of cardiovascular disease. However, the role of admission MCV in predicting MACEs following stent implantation in diabetes mellitus (DM), non-DM, or whole patients with ACS remains largely unknown. Methods and Results. A total of 437 ACS patients undergoing stent implantation, including 294 non-DM (59.08±10.24 years) and 143 DM (63.02±9.92 years), were analyzed. Admission MCV was higher in non-DM than DM patients. During a median of 31.93 months follow-up, Kaplan-Meier curve demonstrated that higher admission MCV level was significantly associated with increased MACEs in whole and non-DM, but not in DM patients. In Cox regression analysis, the highest MCV tertile was associated with higher MACEs in whole ([HR] 1.870, 95% CI 1.113-3.144, P=0.018), especially those non-DM ([HR] 2.089, 95% CI 1.077-4.501, P=0.029) patients after adjustment of several cardiovascular risk factors. MCV did not predict MACEs in DM patients. During landmark analysis, admission MCV showed better predictive value for MACEs in the first 32 months of follow-up than in the subsequent period. Finally, the receiver operating characteristic (ROC) curve was conducted to confirmed the value of admission MCV within 32 months. Conclusion. In patients with ACS, elevated admission MCV is an important and independent predictor for MACEs following stent implantation, especially amongst those without DM even after adjusting for lifestyle and clinical risk factors. However, as the follow-up period increased, the admission MCV lost its ability to predict MACEs.

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“… 4 , 5 It has been recommended that measuring homocysteine, a nonspecific functional biomarker of FD, is a more sensitive way of detecting FD than assessing blood folate. 6 It is worth remembering that hyperhomocysteinemia is also present in cobalamin deficiency, so a correct interpretation of homocysteine comes at the expense of concurrently measuring vitamin B12, or rather, its associated metabolite, methylmalonic acid, whose levels will be increased even in the presence of borderline cobalamin levels. A comprehensive review of folate biomarkers and their caveats can be found elsewhere.…”

mentioning

confidence: 99%

It is never too late to rethink serum folate

Fertrin

2018

Hematology, Transfusion and Cell Therapy

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Anemia

Cited by 72 publications

References 14 publications

Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia

Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia

Prognostic Value of Admission Mean Corpuscular Volume for Major Adverse Cardiovascular Events following Stent Implantation in Nondiabetic and Diabetic Patients with Acute Coronary Syndrome

It is never too late to rethink serum folate

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