Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Abstract

Aim: Although higher adiponectin levels predict a low risk of type 2 diabetes, elevated adiponectin levels predict higher mortality in older persons. Methods: We examined the associations of adiponectin with anthropometric, metabolic and hematological variables and renal function in 361 community-dwelling elderly women aged 76±8. Renal function was assessed using the estimated glomerular filtration rate (eGFR).

WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

“…According to existing evidences, chronic kidney failure, renal failure, and high adiponectin levels in T1DM and T2DM patients may be all related to nephropathy pathogenesis [23,[33][34][35][36][37]. The adiponectin protein encoded by the ADIPOQ gene can prevent vascular remodeling by inhibiting the proliferation and migration of smooth muscle cells and reduce TNF-α production to modulate the inflammatory response of endothelial cells [38,39].…”

<i>CDH13</i> Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass

“…Adiponectin levels have been shown to be increased due to reduced renal function [33][34][35] and decreased by cigarette smoking 36) . Reduced renal function would decrease the clearance of adiponectin, resulting in an increase in circulating adiponectin levels, even in the healthy subjects.…”

Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1

“…Kidney function was evaluated in the present study as well, because it is also well known that declining kidney function is common in the elderly and is associated with dysregulation of serum adipokines. [11][12][13] Methods We examined 159 community-living elderly women whose details have been reported elsewhere. 13 They were residents in Nishinomiya, an urban area of Hyogo, Japan and were recruited as volunteers by local welfare commissioners from the city of Nishinomiya.…”

“…[11][12][13] Methods We examined 159 community-living elderly women whose details have been reported elsewhere. 13 They were residents in Nishinomiya, an urban area of Hyogo, Japan and were recruited as volunteers by local welfare commissioners from the city of Nishinomiya. Although 43, 9, and 58 women (27.0%, 5.7%, and 36.5%, respectively) reported to be receiving statins, antidiabetic drugs, and antihypertensive drugs, respectively, detailed drug information was not available.…”

“…We evaluated routine chemical parameters, including glucose, insulin, serum lipids, and lipoproteins as previously reported. 13 Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR) using fasting plasma glucose and insulin levels. 14 Lipoprotein lipase mass in preheparin serum (from now on referred to as basal LPL) was measured by the sandwich enzymelinked immunosorbent assay (ELISA) with a specific monoclonal antibody against bovine milk LPL 15 using commercially available kits from Daiichi Pure Chemicals [interassay coefficient of variation (CV) = 2.8%].…”