Anemia as a Presenting Manifestation of Giant Cell Arteritis

Healey, L. A.; Wilske, Kenneth R.

doi:10.1002/art.1780140105

Cited by 31 publications

(8 citation statements)

References 7 publications

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“…The numerous series, reviews and case reports on temporal arteritis have undoubtedly resulted in an increased awareness of this disease [2,5,6]. Less well-known, however, is the fact that giant cell arteritis frequently presents with predominantly or solely vague constitutional symptoms such as fever, fatigue, anorexia, weight loss and anaemia [3,7,8]. This type of presentation was termed occult giant cell arteritis [3].…”

Section: Discussionmentioning

confidence: 99%

Temporal arteritis: the silent presentation and delay in diagnosis

Desmet¹,

Knockaert²,

Bobbaers³

1990

Journal of Internal Medicine

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To determine the frequency of the so-called silent or occult presentation of temporal arteritis (presentation with mere constitutional symptoms) and the resulting delay in diagnosis in this particular group, the medical records of all patients (n = 82) with temporal arteritis or polymyalgia rheumatica, presenting between 1982 and 1988 at the Department of General Internal Medicine of the University Hospital, were retrospectively analysed. Only biopsy-proven cases (n = 34) were studied further. Of the 34 patients with temporal arteritis, 13 (38%) presented with the silent or occult form. In this group the mean delay in diagnosis was 21.5 d (range 2-105) in contrast to a delay of 8.5 d (range 1-40) in the other group (P less than 0.05). Increased awareness of this presentation should lead to earlier diagnosis and treatment of this potentially life-threatening disease, resulting in a shorter hospital stay and fewer technical investigations, with a considerable financial saving.

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Section: Discussionmentioning

confidence: 99%

Temporal arteritis: the silent presentation and delay in diagnosis

Desmet¹,

Knockaert²,

Bobbaers³

1990

Journal of Internal Medicine

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“…liferative anemia (5), and increased plasma a,-globulins. Their relationship has been cemented by the recognition of myalgias in patients with temporal arteritis (6) and by the finding of occult giant cell arteritis in the temporal arteries of many patients with polymyalgia rheumatica (7).…”

mentioning

confidence: 96%

Familial aggregation of polymyalgia rheumatica and giant cell arteritis

Liang

Simkin

Hunder

et al. 1974

Arthritis & Rheumatism

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Four pairs of first-degree relatives with polymyalgia rheumatica, giant cell arteritis, or both have been encountered among approximately 250 such patients. Two of these pairs were mother-daughter combinations, the first such cases to be reported. Chance alone is unlikely to account for this association. The possible roles of environmental, genetic, and immunologic factors are considered.A clear relationship has been established in recent years between polymyalgia rheumatica and giant cell arteritis (temporal arteritis, cranial arteritis) (1-4). Both occur in older patients, are associated with systemic signs, respond exceptionally well to corticosteroid therapy, and share characteristic laboratory findings including a fast erythrocyte sedimentation rate, hypopro-

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“…If physical examination is normal and simple investigations such as white cell count, urine and blood cultures, chest X-ray, autoimmune and myeloma screens are all negative, an occult neoplasm may be sought. If no such neoplasm is found, a temporal artery biopsy should be performed even if the charac- (Healey & Wilske, 1971. However, as Allsop & Gallagher report (1981), a negative temporal artery biopsy does not exclude GCA and, if the biopsy is negative, the physician may be left with an ill elderly patient for whom further costly and uncomfortable investigations are unlikely to turn up an unsuspected treatable condition.…”

Section: Discussionmentioning

confidence: 99%

Steroid sensitive systemic disease with anaemia in the elderly: a manifestation of giant cell arteritis?

Allison

Gough

1985

Postgraduate Medical Journal

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Summary Nine elderly patients presented with features of a multisystem disorder thought to be either a connective tissue disease of undefined type or disseminated malignancy. Associated features were a normochromic anaemia, raised erythrocyte sedimentation rate (ESR) (or plasma viscosity) and raised serum alkaline phosphatase levels. None had symptoms to suggest either giant cell arteritis or polymyalgia rheumatica. Temporal artery biopsy was performed before trial of corticosteroid therapy in four, and two showed giant cell arteritis. All nine responded dramatically to corticosteroids and the anaemias resolved. One died after 6 y, and the rest are well after 1 to 7 y.

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Anemia as a Presenting Manifestation of Giant Cell Arteritis

Cited by 31 publications

References 7 publications

Temporal arteritis: the silent presentation and delay in diagnosis

Temporal arteritis: the silent presentation and delay in diagnosis

Familial aggregation of polymyalgia rheumatica and giant cell arteritis

Steroid sensitive systemic disease with anaemia in the elderly: a manifestation of giant cell arteritis?

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