Anemia dan Lama Konsumsi Obat Anti Tuberculosis

Abstract

<p style="text-align: justify;">Tuberculosis is an infectious disease due to Mycobacterium tuberculosis germ that can infect several organs, including the lungs, kidneys, and bones. The goal of treatment of tuberculosis is tuberculosis bacilli destroy quickly and prevent recurrence. First category treatment of tuberculosis is isoniazid, rifampin, streptomycin, ethambutol, and pyrazinamide. Although the most anti-tuberculosis drug is acceptable in therapy, but have potentially toxic effects hematologic reactions such as agranulocytosis, eosinophilia, thrombocytopenia, and anemia. This research aims to know the correlation between anti-tuberculosis drug consumption in pulmonary TB patients against anemia. Method of this research was Analytical Survey with a Cross-Sectional design. The average results of red blood cell count for 0 months 5,16 106/uL, 2 months 4,39 106/uL and 6 months 4,61 106/uL, haemoglobin levels for 0 month 15,17 g/dL, 2 months 12,73 g/dL and 6 months 13,28 g/dL as well as hematocrit value for 0 month 44,26 %, 2 months 38,24 % and 6 months 39,04 %. From Spearman statistics analytical was obtained significant of red blood cell count 0.004 < α (0.05), levels of hemoglobin 0.007 < α (0.05) and the value of hematocrit 0.015 < α (0.05), it was concluded there was correlation between long consumption of anti-tuberculosis drug with anemia and the value of the correlation coefficient count of red blood cells -0.531, levels of hemoglobin-0.479 as well as the value of hematocrit -0.440 means has the power correlations are medium. Further research is recommended to use different parameters such as the number of platelets, AST/ALT levels and should use the same patient sample or from 0 months up to 6 months </p>

Erythrocyte Morphology of Tuberculosis Patients

“…According to a study conducted by Fauziah and Siahaan (2014), the administration of anti-tuberculosis drugs affected the picture of hemoglobin in pulmonary TB patients, the decrease in hemoglobin levels was significant in 3 months of treatment, especially in the 3rd month of treatment 6 . The results of the study by Thuraidah et al (2017), the results of the average examination of red blood cell count, hemoglobin level and hematocrit value of pulmonary TB patients in the second month experienced anemia and there was a relationship between the duration of consumption of anti-tuberculosis drugs against anemia in pulmonary TB patients 7 . Table 1 shows there are 74% of Normocytic normochrome erythrocytes, according to the theory of Hoffbrand & Moss (2013), one of the most common types of anemia in patients with various chronic inflammatory or malignant diseases, one of which is the normocytic or hypochrome erythrocyte morphology light 8 .…”

Pengaruh Pemberian Obat Anti Tuberkulosisi (OAT) Terhadap Jumlah Trombosit pada Pasien TB Paru di BKPM Purwokerto

“…Berdasarkan beberapa penelitian yang ada, OAT dapat berpengaruh pada obat rifampisin dan isoniazid, yang memiliki efek samping terhadap organ terutama dalam sistem hematologi (Haliza, Wardani, Sudarsono, & Mulyanto, 2022). Thuraidah et al (2017), menyatakan bahwa efek samping OAT dapat menyebabkan anemia, selain itu kandungan OAT pada jenis rifampisin merupakan salah satu jenis obat yang dapat menyebabkan efek samping kelainan hematologis yaitu trombositopenia (penurunan jumlah trombosit). Penurunan jumlah trombosit disebabkan oleh terjadinya lisis dalam sirkulasi, dimana terjadi pada sebagian besar trombositopenia yang tergantung dari obat.…”

Citrus Hystrix D.C Fluid Inhibits the Growth of Escherichia Coli, Pseudomonas aerogenosa, and Bacillus subtilis

“…The bacterial infection is still a health problem in Indonesia. Bacterial diseases such as tuberculosis 1,2,3 and Staphylococcus aureus 4,5 . There are also problems with bacterial environmental contaminants such as Salmonella 6 , E. coli 7 , Staphylococcus aureus 8,9 and Bacillus 10,11 .…”