Anemia de las enfermedades crónicas asociada a obesidad: papel de la hepcidina como mediador central

H, Pía Villarroel; O, Miguel Arredondo; G, Manuel Olivares

doi:10.4067/s0034-98872013000700008

Cited by 10 publications

(8 citation statements)

References 55 publications

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“…Hepcidin was found in higher titers in obese and overweight individuals. Hepcidin works by causing subclinical inflammation, decreases iron absorption from the gut, and blunts the effects of iron fortification [28, 29]. Reducing weight may lower hepcidin, which may in return improve the iron stores of the body.…”

Section: Discussionmentioning

confidence: 99%

Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People

et al. 2016

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Background. In clinical practice, serum ferritin is used as a screening tool to detect iron deficiency. However, its reliability in obesity has been questioned. Objectives. To investigate the role of ferritin in overweight and obese people, either as a marker of inflammation or iron deficiency. Methods. On the basis of body mass index (BMI), 150 participants were divided into three equal groups: A: BMI 18.5–25 kg/m2, B: BMI 25–30 kg/m2, and C: BMI > 30 kg/m2. Serum iron, total iron binding capacity (TIBC), transferrin saturation, ferritin, C-reactive protein, and hemoglobin (Hb) were measured for each participant and analyzed through SPSS version 16. One-way ANOVA and Pearson's correlation tests were applied. Results. Ferritin was the highest in group C (M = 163.48 ± 2.23, P < 0.001) and the lowest in group A, (M = 152.78 ± 1.81, P < 0.001). Contrarily to ferritin, transferrin was the lowest in group C, (M = 30.65 ± 1.39, P < 0.001) and the highest in group A, (M = 38.66 ± 2.14, P < 0.001). Ferritin had a strong positive correlation with both BMI (r = 0.86, P < 0.001) and CRP (r = 0.87, P < 0.001) and strong negative correlation with Hb, iron, TIBC, and transferrin saturation (P < 0.001). Conclusion. Ferritin is a marker of inflammation rather than iron status in overweight and obese people. Complete iron profile including transferrin, rather than serum ferritin alone, can truly predict iron deficiency in such people.

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Section: Discussionmentioning

confidence: 99%

Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People

et al. 2016

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“…Higher EPO concentration among pregnant women with larger bodies may be a response to two concomitant mechanisms: First, the anti-inflammatory and cytoprotective role of EPO against hypoxia-induced inflammation of the adipose tissue resulting from obesity [21,22]; and second, having a larger body results in increased need of iron to meet greater tissue oxygen demands.…”

Section: Discussionmentioning

confidence: 99%

Erythropoiesis and Red Cell Indices Undergo Adjustments during Pregnancy in Response to Maternal Body Size but not Inflammation

et al. 2020

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During human pregnancy, iron requirements gradually increase, leading to higher amounts of erythropoietin (EPO) and reticulocytes, and changes in erythrocyte size and density. Women with pregestational obesity experience “obesity hypoferremia” during pregnancy, which alters iron homeostasis. In this study we aimed to describe the relationship between EPO and iron nutrition status during nonanemic pregnancy, and to explore whether obesity and inflammation influence erythropoiesis and red cell indices. We conducted a secondary analysis of a cohort followed throughout pregnancy. Participants were nonanemic women assigned to two study groups based on pregestational body mass index (pgBMI): adequate weight (AW, n = 53) or obesity (Ob, n = 40). All received a multivitamin supplement. At gestational ages (GA) 13, 21, 28 and 34, we measured hemoglobin and red cell indices with an ACT-5DIFF hematology counter, and reticulocyte percentage by manual cell counting. EPO, interleukin (IL–6) and markers of iron status, i.e., hepcidin, serum transferrin receptor (sTfr) and ferritin, were measured by ELISA. Bivariate correlations showed that EPO was positively associated with pgBMI, GA, sTfr and IL-6, but negatively associated with hepcidin, ferritin and hemoglobin, and unrelated to iron intake. Generalized linear models adjusted for confounding factors showed that EPO and erythrocyte concentrations were significantly higher in women in the Ob group, while mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and red cell distribution width (RDW) were lower; reticulocytes and mean corpuscular hemoglobin concentration (MCHC) were not different. Differences were not altered when controlling for inflammation (IL–6). These changes suggest that, in addition to altering iron metabolism, a larger maternal body size during pregnancy results in higher erythropoiesis without increasing hemoglobin, which is exhibited in the latter being distributed among more and smaller erythrocytes.

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“…Serum ferritin is a marker of inflammation in obese subjects, the high BMI is to have a high level of serum ferritin, which can be caused because of the dominant inflammatory conditions, in the presence of an increased adipose tissue [12]. as diluted hypoferremia, lack of dietary iron intake, increased iron demand, and/or iron absorption disorder, hepcidin has recently been identified as a major cause of obesity ID or IDA [23].…”

Section: Discussionmentioning

confidence: 99%

The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

Shoon¹

2017

jkbns

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The purpose of this study was to investigate the difference in serum ferritin and leukocyte regarding overweight and obese South Korean adults. Methods: This study was conducted on 5,281 subjects older than 19, according to data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-3), 2015. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffe' s test, Pearson' s correlation coefficient, and stepwise multiple regression analysis (SPSS 24.0). Results: First, serum ferritin and leukocyte were higher regardubg obesity, followed by being overweight and within normal weight. Second, body mass index (BMI) was positively correlated with serum ferritin and leukocyte. Third, factors affecting serum ferritin were gender, and being obese and overweight. Explanatory power of the model was 26.2%. Factors affecting leukocyte were gender, obesity, being overweight, and weight change over the past year (weight gain). Explanatory power of the model was 10.2%. Conclusion: Obesity and being overweight were factors affecting serum ferritin and leukocyte, and obesity was more affected than being overweight in Koreans older than 19. In conclusion, serum ferritin was a marker of inflammation, rather than iron status, in overweight and obese Korean adults.

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Anemia de las enfermedades crónicas asociada a obesidad: papel de la hepcidina como mediador central

Cited by 10 publications

References 55 publications

Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People

Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People

Erythropoiesis and Red Cell Indices Undergo Adjustments during Pregnancy in Response to Maternal Body Size but not Inflammation

The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

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