Anemia in Childhood

Khan, Leah

doi:10.3928/19382359-20180129-01

Cited by 34 publications

(20 citation statements)

References 12 publications

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“…This problem particularly concerns two main at-risk target groups: preschool children and young women [ 9 ]. The iron deficiency may affect school children (above 5 years) to a lesser extent than it does preschool children, but due to the increased demand related to the growth and development of the body, school children may also be at risk of iron deficiency and iron deficiency anemia [ 10 ]. In addition, obesity-related iron deficiency may impair brain development in children, which may disturb cognitive function, motor skills and behavior [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

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Section: Introductionmentioning

confidence: 99%

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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“…(42) Estudos ainda destacam a importância da prevenção da anemia ferropriva, portanto este assunto também deve ser abordado pelos enfermeiro pediatras, orientando os pais sobre a necessidade de ferro ao organismo infantil e as suas principais fontes. (42,43) A oferta de medicamentos às crianças foi elevada nesta pesquisa, mais frequentemente entre mães com maior escolaridade e multíparas. Tais resultados foram semelhantes a outro estudo, que analisou a oferta de fármacos e automedicação pelas mães aos seus filhos em hospital universitário da Espanha.…”

Section: Discussionunclassified

Uso de medicamentos em crianças menores de um ano

Souza¹,

Batista²,

Tacla³

et al. 2020

Revista Da Sociedade Brasileira De Enfermeiros Pediatras

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Objetivo: Analisar o uso de medicamentos em crianças do nascimento ao primeiro ano de vida. Métodos: Estudo descritivo longitudinal, realizada entre 2013 e 2015. Foram realizadas entrevistas com 302 mães em quatro etapas: no pós-parto ainda na maternidade, consulta de retorno puerperal imediato sete dias após o parto, visita domiciliar 42 dias pós-parto e visita domiciliar um ano pós-parto. Resultados: O uso de medicamentos nos primeiros 42 dias de vida foi de 76,8%, enquanto no decorrer de um ano, aumentou para 99%, a automedicação foi realizada em 27,8% das crianças. Os medicamentos mais utilizados foram paracetamol (85,1%), dimeticona (61,9%) e antianêmicos (40,1%). Os motivos para utilização foram, cólica abdominal, febre, dor, irritabilidade e vacinação. Conclusão: Foi elevada a incidência do uso de medicamentos, considerando que parte dos sintomas descritos pelas mães podem ser contidos com terapias não farmacológicas. Ressalta-se a necessidade de ações para prevenir o uso indiscriminado de medicamentos para crianças.

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“…Among the biomarkers recommended by the World Health Organization (WHO) for assessment of iron status, a combination of ferritin and soluble transferrin receptor (sTfR) levels reflects the full spectrum of iron status from normal iron stores to tissue iron deficiency [5,6]. Assessment of sTfR is particularly important in contexts where iron requirements and cellular uptake are increased for growth and development, such as during pregnancy [7,8], infancy [9,10], and early childhood [11,12]. Elevated sTfR concentrations are observed in iron-deficient erythropoiesis, with levels rising even prior to decline in haemoglobin concentrations.…”

Section: Introductionmentioning

confidence: 99%

Rapid diagnostics for point-of-care quantification of soluble transferrin receptor

Srinivasan

Finkelstein

O'Dell³

et al. 2019

EBioMedicine

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Background Iron deficiency (ID) and anaemia are major health concerns, particularly in young children. Screening for ID based on haemoglobin (Hb) concentration alone has been shown to lack sensitivity and specificity. The American Academy of Pediatrics (AAP) recommends soluble transferrin receptor (sTfR) as a promising approach to screen for iron deficiency. However, in most settings, assessment of iron status requires access to centralized laboratories. There is an urgent need for rapid, sensitive, and affordable diagnostics for sTfR at the point-of-care. Methods An immunochromatographic assay-based point-of-care screening device was developed for rapid quantification of sTfR from a drop of serum within a few minutes. Performance optimization of the assay was done in sTfR-spiked buffer and commercially available sTfR calibrator, followed by a small-scale proof-of-concept validation with archived serum samples. Findings On preliminary testing with archived serum samples and comparison with Ramco ELISA, a correlation of 0.93 (P < 0.0001) was observed, demonstrating its potential for point-of-care assessment of iron status. Interpretation The analytical performance of the point-of-care sTfR screening device indicates the potential for application in home-use test kits and field settings, especially in low- and middle-income settings. An added advantage of sTfR quantification in combination with our previously reported serum ferritin diagnostics is in integration of Cook's equation as a quantitative and minimally-invasive indicator of total body iron stores. Fund Thrasher Research Fund (Early Career Award #13379), NIH R03 EB 023190, NSF grant #1343058, and Nutrition International (project #10-8007-CORNE-01).

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Anemia in Childhood

Cited by 34 publications

References 12 publications

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Uso de medicamentos em crianças menores de um ano

Rapid diagnostics for point-of-care quantification of soluble transferrin receptor

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