Anemia in chronic kidney disease patients in predialysis and postdialysis stages

Bhatta, Sushama; Aryal, Gopi; Kafle, RK

doi:10.3126/jpn.v1i1.4446

Cited by 17 publications

(17 citation statements)

References 10 publications

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“…Inflammation caused by the dialytic membrane can lead to lower mean Hb and Hct levels in dialysis patients. 9 Our study showed significant patients, which is similar to the study done by Seuga et al 10 The degree of anaemia increases as progressive destruction of kidney tissue occurs. This study like others revealed presence of a predominantly moderate degree of anaemia in pre-and post-dialysis patients.…”

Section: Discussionsupporting

confidence: 91%

Anaemia and Chronic Kidney Disease

Farooque¹,

Bhushan²

2017

jebmh

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BACKGROUND Blood haemoglobin (Hb) concentration serves as the key indicator for anaemia, because it can be measured directly. Aim: To determine the profile of anaemia and to correlate the severity of anaemia with serum creatinine levels in pre-and postdialysis CKD patients. MATERIALS AND METHODS The study was carried out over a period of 6 months. The study consisted of 40 pre-and post-dialysis CKD patients. Venous blood samples were obtained from patients before dialysis and after completion of dialysis. Hb, Hct and Red cell indices were calculated, peripheral blood smears were studied for red blood cell morphology and serum creatinine levels. RESULTS Of the 40 CKD patients, 20 (50%) were male and 20 (50%) were female. The age of the patients ranged from 20-83 years with mean age being 46.1 ± 1754 years. The most frequent causes of CKD was hypertension 30 (75%). Normocytic and normochromic anaemia was predominant in both pre-and post-dialysis patients. In post-dialysis patients, microcytic hypochromic and macrocytic normochromic anaemia was higher than in pre-dialysis patients (20% and 7.5%, respectively). Severe anaemia is increased in post-dialysis patients, i.e. 20% in pre-dialysis it is 5%. There was a significant difference in the Hb and Hct levels between post-dialysis and pre-dialysis patients (P < 0.001). The prevalence of anaemia was 100% in both pre-and post-dialysis patients. The relationship between Hb and Serum creatinine levels was determined using linear regression and correlation. The correlation between Hb and SC levels was not significant in both the pre-and post-dialysis groups (P > 0.05). CONCLUSION The most frequent anaemia in chronic kidney disease patients was normocytic and normochromic type of a moderate degree. Significant correlation was not found between the severity of anaemia and serum creatinine levels in both pre-and post-dialysis group of patients.

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Section: Discussionsupporting

confidence: 91%

Anaemia and Chronic Kidney Disease

Farooque¹,

Bhushan²

2017

jebmh

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“…The nding of this study is also very different from the Dialysis Outcomes and Practice Patterns study (DOPPS) international study, which reported a range of anemia prevalence from 23-77% in the studied countries [10]. However the present study is in agreement with the nding of earlier studies which found anemia in all studied patients [19]. It does also identify a greater prevalence of anemia in African descent patients that is inconsistent with the 67.5% found by a Brazilian study [20].…”

Section: Discussionsupporting

confidence: 59%

Prevalence and factors predicting anemia in sudanese hemodialysis patients

Abdelkarim

Abdelraheem

Abubakar³

et al. 2020

Preprint

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Background: Anemia is a deleterious complication of end stage renal disease (ESRD). It is highly prevalent in sub-saharan Africa. The predictors of control of hemoglobin levels in ESRD patients in Sudan are unknown. Methods: A prospective observational study was conducted to evaluate the prevalence of anemia and factors affecting the control of hemoglobin levels in ESRD patients. A standardized data collection form was used for collecting patient information. A total of 1015 hemodialysis patients were recruited from twelve centers. Results: The 534 (52.6%) patients were included in the final analysis. Those were excluded, including, 194 (19.1%) patients were transferred to other centers before completion of the study, 165 (16.3%) died, 38 (3.7%) underwent renal transplantation and 84 (8.3%) were lost to follow-up. Among the patients who included in the final analysis, 307 (57.5%) were males and the mean age was 48.7±16.1 years. All the analyzed patients were anemic (hemoglobin level<12 g/dL), 67% had a hemoglobin level <10 g/dL. In multivariate analysis the variables which had statistically significant associations with hemoglobin levels equal or higher than 10 g/dL were insured patients [OR = 1.53, 95% CI (1.04–2.25)]; and two drug combinations: "Erythropioesis simulating agent (ESA), intravenous (IV) iron, oral iron, and vitamins" [OR = 1.87, (1.27–2.76)] and "ESA, oral iron and vitamins" [OR = 6.67, (2.98–14.94)]. While, a family history of ESRD [OR = 0.57, (0.35–0.94)] and duration of hypertension for "6-9 years" [OR = 0.47, (0.25–0.87)]; Female patients were identified as being more likely to have lower hemoglobin in both univariate and multivariate analyses. Conclusion: There was suboptimal treated anemia requiring attention in this population. Patients with a family history of ESRD and duration of hypertension for "6-9 years" were predicted to have lower hemoglobin levels. More concern should be paid to uninsured patients and anemia drugs, including the ESA and iron preparations. The results of this study increase our knowledge about the prevalence of anemia and the factors that contribute to control of hemoglobin levels in Sudan. Keywords: Prevalence, Anemia in ESRD, Hemodialysis, Erythropioesis Stimulating Agents, Hemoglobin Level, Health Insurance, Hypertension, Family History of ESRD, Sudan, Khartoum.

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“…Urinary protein:creatinine ratio was found to not correlate with either HGB or HCT. A lack of correlation between creatinine concentration and the severity of anemia has been documented in human studies; 28 it has been proposed to result from the insensitivity of blood creatinine in detecting a decline in glomerular filtration rate (GFR), arising from changes in both the metabolism and renal handling of creatinine, and from compensatory mechanisms that serve to maintain normal GFR despite a reduction in functional renal mass. 27,29 There was also a correlation between the increase in blood pressure and decline in HGB and HCT, although not as strong as that seen for plasma urea.…”

Section: Discussionmentioning

confidence: 99%