Anemia in Patients With Diabetes and Prediabetes With Normal Kidney Function: Prevalence and Clinical Outcomes

Erez, Daniel; Shefler, Coral; Roitman, Eytan; Levy, Sigal; Dovrish, Zamir; Ellis, Martin; Twito, Orit

doi:10.1016/j.eprac.2021.10.005

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Along these lines, reduced hemoglobin levels could potentially identify DM patients at increased risk of hospitalization and mortality [ 33 ]. The prevalence of anemia in DM patients (both types 1 and 2) has been reported to display ethnic and geographic variations, ranging between 14% and 45%, among different populations worldwide [ 24 , 31 , 32 , 34 , 35 , 36 ]. The insidious development of anemia in DM patients was also shown to be more frequent in men and women older than 60 years of age [ 31 ].…”

Section: Epidemiology and Subtypes Of Anemia In Diabetesmentioning

confidence: 99%

“…In DM patients, however, no concrete clinical evidence is available that mechanistically links proteinuria with anemia. Remarkably, a recent study found a significant prevalence of anemia unrelated to renal failure, both in patients with DM and pre-DM, suggesting that compromised renal function is one of several players in the pathogenesis of anemia in DM patients [ 35 ].…”

Section: Multifactorial Mechanisms Of Rbc Dysfunction and Anemia In D...mentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications

et al. 2023

View full text Add to dashboard Cite

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting evidence suggests that red blood cell (RBC) alterations are both a cause and consequence of disturbances related to DM-associated complications. Importantly, a significant proportion of DM patients develop varying degrees of anemia of confounding etiology, leading to increased morbidity. In chronic hyperglycemia, RBCs display morphological, enzymatic, and biophysical changes, which in turn prime them for swift phagocytic clearance from circulation. A multitude of endogenous factors, such as oxidative and dicarbonyl stress, uremic toxins, extracellular hypertonicity, sorbitol accumulation, and deranged nitric oxide metabolism, have been implicated in pathological RBC changes in DM. This review collates clinical laboratory findings of changes in hematology indices in DM patients and discusses recent reports on the putative mechanisms underpinning shortened RBC survival and disturbed cell membrane architecture within the diabetic milieu. Specifically, RBC cell death signaling, RBC metabolism, procoagulant RBC phenotype, RBC-triggered endothelial cell dysfunction, and changes in RBC deformability and aggregation in the context of DM are discussed. Understanding the mechanisms of RBC alterations in DM provides valuable insights into the clinical significance of the crosstalk between RBCs and microangiopathy in DM.

show abstract

Section: Epidemiology and Subtypes Of Anemia In Diabetesmentioning

confidence: 99%

Section: Multifactorial Mechanisms Of Rbc Dysfunction and Anemia In D...mentioning

confidence: 99%

Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications

et al. 2023

View full text Add to dashboard Cite

show abstract

Low hemoglobin, even within the normal range, is associated with diabetic kidney disease

Wang,

Tang

et al. 2024

Diabetes & Metabolism

View full text Add to dashboard Cite

The Prevalence and Characteristics of Anemia in Romanian Patients with Type 2 Diabetes: A Cross-Sectional Study

Gaita,

Timar,

Lazar

et al. 2024

JCM

View full text Add to dashboard Cite

Background/Objectives: Anemia is a prevalent comorbidity of diabetes, and although various mechanisms have been shown to link these two conditions, their interaction has not been sufficiently explored. Our cross-sectional, non-interventional study aimed to evaluate the prevalence of anemia and its subtypes, as well as their interactions, in patients with type 2 diabetes (T2D). Methods: A total of 227 patients previously diagnosed with T2D were enrolled. These patients were assessed regarding their medical history and the evolution of their diabetes, and were screened for anemia. Results: Anemia was encountered in 32.6% of the 227 hospitalized patients previously diagnosed with T2D enrolled in this study. Its presence was associated with a higher prevalence of complications and comorbidities, such as chronic kidney disease (CKD), retinopathy, and atrial fibrillation. The most common types of anemia observed were those associated with CKD, other chronic conditions, and iron deficiency. A moderate, positive correlation (r = 0.307; p < 0.0001) has been observed between estimated glomerular filtration rate (eGFR) and hemoglobin, and a moderate, negative correlation has been observed between age and hemoglobin (r = −0.351; p < 0.0001), with the results also analyzed using multiple regression and ROC curve analysis. Additionally, a weak, positive, yet statistically significant correlation was observed between glycemic values and hemoglobin levels, which requires further research. Conclusions: Anemia is frequently encountered in patients with T2D, especially in those with increased age, decreased eGFR, and additional chronic degenerative complications or other comorbidities; thus, a systematic screening for an early diagnosis and interdisciplinary management is recommended for improved outcomes related to morbidity, mortality, and quality of life.

show abstract

Anemia in Patients With Diabetes and Prediabetes With Normal Kidney Function: Prevalence and Clinical Outcomes

Cited by 3 publications

References 33 publications

Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications

Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications

Low hemoglobin, even within the normal range, is associated with diabetic kidney disease

The Prevalence and Characteristics of Anemia in Romanian Patients with Type 2 Diabetes: A Cross-Sectional Study

Contact Info

Product

Resources

About