Hetero‐modulated neural activation is vital for adaptive information processing and learning that occurs in brain. To implement brain‐inspired adaptive processing, previously various neuro‐transistors oriented for synaptic functions had been extensively explored, however, the emulation of nonlinear neural activation and hetero‐modulated behaviors had been not possible due to the lack of threshold switching behavior in a conventional transistor structure. Here, we report a two‐dimensional van der Waals (vdW) float gate transistor (FGT) that exhibits steep threshold switching behavior, and the emulation of hetero‐modulated neuron functions (integrate‐and‐fire, sigmoid type activation) for adaptive sensory processing. Unlike conventional FGTs, the threshold switching behavior stems from impact ionization in channel and the coupled charge injection to float gate. When a threshold is met, a sub‐30 mV/dec increase of transistor conductance by more than four orders is triggered with a typical switch time of ∼milliseconds. Essentially, by feeding light sensing signal as the modulation input, we demonstrate that two typical tasks that relies on adaptive neural activation, including collision avoidance and adaptive visual perception, can be realized. Our results may shed light on the emulation of rich hetero‐modulating behaviors in biological neurons and the realization of biomimetic neuromorphic processing at low hardware cost.This article is protected by copyright. All rights reserved