Anemia in Uremia

Abstract

Abstract. One hundred and thirty‐eight patients with renal insufficiency of varying degree have been studied with respect to anemia and signs of hemolysis. A control material is included in the study. 1) The patient group displayed a normochromic anemia with only a slightly subnormal mean corpuscular hemoglobin concentration. 2) A moderately elevated reticulocyte count together with a tendency to elevated endogenous carbon monoxide production indicated a certain degree of hemolysis in the uremic patient group compared with the controls. Patients with chronic pyelonephritis and active urinary infection displayed an elevated reticulocyte count (p < 0.001) and lower haptoglobin values (0.05 > p > 0.01) than non‐infected uremic patients. Thus we consider these infections to be a hemolysis‐promoting factor in patients with renal insufficiency. 3) In men there was a positive correlation between the concentrations of serum creatinine versus serum iron concentration and the saturation percentage of the total iron binding capacity. In the light of cited iron kinetic data, we consider this correlation an indicator of depressed erythropoiesis. 4) A selected group of severely ill uremic patients were studied with respect to their erythrocyte life span by the bilirubin turnover method. As a group, they displayed a shortened erythrocyte life span in comparison with an earlier published control group.

Συμβολη Στη Διαγνωστικη Αξια Της Φερριτινης Του Ορου Σε Διαταραχες Της Οικονομιας Του Σιδηρου Στον Οργανισμο

“…Δεδομένου δτι τά περιστατικά πού μελέτησαν ot ερευνητές αυτοί δέν περιλάμβαναν μόνο τήν αμιγή αναιμία της χρόνιας νεφρικής ανεπάρκει ας άλλα καί αναιμίες άλλης αίτιολογίας, (κυρίως σιδηροπενικές καί μεγαλοβλαστικές άπό έλλειψη φυλλικοϋ οξέος) πρέπει νά περιμένει κα νείς δτι τό ποσοστό αυτό θά εϋναι πολύ 1 μεγαλύτερο στην αμιγή αναι μία τής χρόνιας νεφρικής ανεπάρκειας (53,55,156).…”

“…"Εχει αποδειχτεί δτι στην ΧΝΑ υπάρχει διαταραχή τοΰ μεταβολισμού τοΰ σιδήρου ένώ ή απορ ρόφηση του είναι κανονική. (53,54,131,134).…”