Anemia, Iron Deficiency and Thalassemia among Adolescents in Northeast Thailand: Results from Two Independent Surveys

Pansuwan, Anupong; Fucharoen, Goonnapa; Fucharoen, Supan; Himakhun, Boonmee; Dangwiboon, Samrit

doi:10.1159/000322666

Cited by 21 publications

(27 citation statements)

References 48 publications

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“…A recent study conducted in Vietnamese children and nonpregnant women revealed results similar to those of this study, with markedly reduced prevalences of anemia, ID, and IDA [20]. Similar findings were also obtained in many studies conducted in Thailand in that the prevalence of IDA was not high [29,30,31,32]. The outcomes of the studies indicate that the burden of anemia due to ID in the region has improved.…”

Section: Discussionsupporting

confidence: 87%

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Burden of Anemia in Relation to Thalassemia and Iron Deficiency among Vietnamese Pregnant Women

et al. 2013

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Background and Aims: Information about the extent to which anemia is related to thalassemia and iron deficiency (ID) is not available in Vietnam. This study investigated the burden of anemia in relation to thalassemia and ID among Vietnamese pregnant women. Methods: A cross-sectional study was conducted in Thua Thien Hue, Central Vietnam. Blood samples taken from 399 pregnant women with a gestational age <12 weeks were analyzed. Anemia was defined as Hb levels <11 g/dl, and ID as ferritin values <15 ng/ml. Results: Out of 399 participants, 77 (19.3%) were anemic. While the prevalence of ID was 20.1%, the prevalence of ID anemia was 6.0%. The overall prevalence of thalassemia was 7.3%. Of the 77 anemic women, 24 (31.2%) had ID, and 20 (26.0%) had thalassemia genes. The rest (42.9%) were anemic due to unknown causes. Conclusions: The results indicate that ID remains a significant health burden among the study population, together with anemia caused by unknown factors. Thalassemias appear not to contribute to a great extent to anemia among Vietnamese pregnant women. Other causes need to be investigated further in order to develop an effective control program for anemia within the population.

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Section: Discussionsupporting

confidence: 87%

“…Several studies conducted in Northeast Thailand have demonstrated that anemia in the region is associated with thalassemia and hemoglobinopathies rather than ID [29,30,31,32]. This seems not to be the case in Vietnam since the prevalence of the 3 clinically significant thalassemias is relatively lower.…”

Section: Discussionmentioning

confidence: 99%

Burden of Anemia in Relation to Thalassemia and Iron Deficiency among Vietnamese Pregnant Women

et al. 2013

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“…While the proportion of thalassemia in the vegans is similar to the autochthonous population, as has been reported previously [17,18,19,20], the proportion of anemia, ID and IDA in the group of vegans is higher than in the general population within the area of northeast Thailand. The findings confirm the increased risk for individuals who are dedicated to a vegan lifestyle and this underlines the need to prevent and control IDA in this specific population.…”

Section: Discussionsupporting

confidence: 84%

“…For IDA, a prevalence range of 1–18% has been reported in pregnant women and school children [17,18,19,20]. There have been no reports for vegetarians.…”

Section: Introductionmentioning

confidence: 99%

Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Wongprachum

Sanchaisuriya

et al. 2012

Acta Haematol

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Background and Aims: The study aimed to determine the proportion of iron deficiency (ID) anemia (IDA) among vegans in northeast Thailand and to explore whether mathematical formulas derived from red blood cell (RBC) indices are applicable for IDA screening in the study population. Methods: Blood samples from 234 individuals (age 6–45 years) living in a vegan community were taken. Complete blood cell count, serum ferritin, hemoglobin profiles and DNA analysis for α-thalassemia were determined. Anemia was defined using the WHO criteria adjusted for age and sex. Serum ferritin <15 ng/ml was considered as ID. A number of mathematical formulas derived from RBC indices were applied to screen ID among anemic individuals. Results: Anemia was found in 41.5% (95% CI = 35.1–48.1%) of the study participants. The overall proportion of thalassemia and hemoglobinopathies was 56.4% (95% CI = 49.8–62.9%). Of the anemic participants, 45.4% had ID. Based on the receiver-operating characteristic curve analysis, 4 formulas were applicable for predicting ID among anemic individuals (highest sensitivity of 86.4%). Conclusions: The proposed formulas might be used as proxy indicators for the identification of ID among anemic children and adult vegans if more sophisticated laboratory determinations are not available due to limited financial resources.

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“…Thalassemia is the most common hematologic disease in Thailand [1,2]. Treatment of thalassemia, which including regular blood transfusion and iron chelation therapy have improved quality of life of these patients and increased their longevity.…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Testicular function in patients with regular blood transfusion for thalassemia major

et al. 2015

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Background: Regular blood transfusion and iron chelation therapy have improved the quality of life of patients with thalassemia and increased their longevity, but transfusion also increases the frequency of endocrine complications, possibly because of iron deposition in the pituitary gland or the gonads, or both. Objective: To evaluate testicular function in patients with thalassemia major by basal hormonal study, and identify risk factors for dysfunction. Methods: We performed a cross-sectional study of 28 patients with thalassemia major aged 11.7 ± 1.8 (8−14.9) years (15 in prepuberty, 13 in puberty with no delayed puberty) who had regular blood transfusions. A normal control group comprised 64 boys who were matched for age and Tanner genital stage. Results: The mean level of serum ferritin in the previous year was 1,575 ± 642 ng/mL, and the onset of blood transfusion was at 3.8 ± 2.3 years and iron chelation therapy was 6.6 ± 2.8 years. The trend for anti-Müllerian hormone levels in patients and controls was similar with age, and although higher in the patients, particularly at Tanner stage II, was not significantly different. Testosterone levels were lower in the patients compared with controls; particularly at Tanner stages IV-V (290.88 vs. 537.4 ng/dL, P < 0.05). Serum follicle-stimulating hormone and luteinizing hormone levels were not significantly different between the groups at any Tanner stage. Conclusion: Patients who received regular blood transfusions had normal Sertoli cell function. Leydig cell dysfunction may occur, even though the patients had a normal pubertal onset.

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Anemia, Iron Deficiency and Thalassemia among Adolescents in Northeast Thailand: Results from Two Independent Surveys

Cited by 21 publications

References 48 publications

Burden of Anemia in Relation to Thalassemia and Iron Deficiency among Vietnamese Pregnant Women

Burden of Anemia in Relation to Thalassemia and Iron Deficiency among Vietnamese Pregnant Women

Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Testicular function in patients with regular blood transfusion for thalassemia major

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