Anemia perniciosa y enfermedades tiroideas autoinmunes en una población mayor de 65 años

Velarde-Mayol, Cristina; Hoz-García, Benito de la; Cañizo-Fernández-Roldán, Carlos del; Hernández-López, Alba Marina; Loza-Candia, Isabel; Cardona-Hernández, Andrea

doi:10.1016/j.regg.2014.10.004

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…When there was a third autoimmune disease the likelihood of AITD and PA increased fourfold. Patients with AITD and taking drugs that affected the absorption of vitamin B 12 had double the probability of developing a PA compared with those who were not taking medications [35]. The occurrence of anti-thyroid antibodies in patients with PA has also been described much earlier at the level of 33% [17], which is consistent with the clinical observation of the coexistence of diseases with autoimmune aetiology in clinical medicine [13,16,[18][19][20].…”

Section: Original Papersupporting

confidence: 73%

“…In view of the fact that PA usually affects adults over 60 years of age, but about 50% of patients are < 60 years old [11], we assessed the levels of antithyroid antibodies in relation to age. So far, the association between AITD and PA among people aged 65 years or older has been confirmed, as well as a progressive increase in the incidence of these diseases ORIGINAL PAPER [35]. In almost half of the PA patients we examined, we found a clear increase in the amount of at least one of the two antibodies responsible for the development of AITD, which is sufficient to recognise the increased risk of Hashimoto's disease, and in combination with hormonal and ultrasound assessment determines the diagnosis of this most common thyroid disease.…”

Section: Original Papermentioning

confidence: 88%

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Pernicious anaemia and endocrine glands antibodies

Morawiec-Szymonik¹,

Fołtyn

Marek

et al. 2019

Endokrynologia Polska

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Introduction: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune haematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests. Material and methods: The study group consisted of 124 persons (men and women) with newly diagnosed pernicious anaemia (PA) and a control group (C) of 41 healthy people. Antibodies against: intrinsic factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb), and pituitary anterior lobe (PituitaryAb) were determined in the blood. Results: 1. The risk of the presence of antibodies against endocrine glands in patients with PA can be classified in order: TPOAb and/or TgAb-41.1%, TPOAb-36.3%, TgAb-25.0%, TPOAb and TgAb-20.2%, AdrenalAb-1.6%, PituitaryAb-0.8%. 2. TPOAb and/or TgAb (mainly TPOAb) are more frequently present in patients with PA, who have IFAb and/or APCA. This correlation is most evident in patients with simultaneous occurrence of IFAb and APCA. 3. Among patients with PA, the simultaneous presence of antibodies IFAb and/ or APCA with TPOAb and/or TgAb antibodies is most likely in women over 45 years of age. 4. In group C, 12% had at least one of two antithyroid antibodies (TgAb twice as often as TPOAb), and 2.4% had both. AdrenalAb and PituitaryAb are not found in healthy persons. Conclusions: In patients with PA, a screening for autoimmune thyroid disease is justified, which should first involve the determination of TPOAb (further TgAb) in the blood. The assessment of antithyroid antibodies should be recommended primarily to patients with PA, who have IFAb and/or APCA, and in particular those with concurrent IFAb and APCA.

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Section: Original Papersupporting

confidence: 73%

Section: Original Papermentioning

confidence: 88%

Pernicious anaemia and endocrine glands antibodies

Morawiec-Szymonik¹,

Fołtyn

Marek

et al. 2019

Endokrynologia Polska

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“…El síndrome tirogástrico autoinmune es definida como la presencia de afección tiroidea de etiología autoinmunitaria (tiroiditis de Hashimoto o enfermedad de Graves) y de gastritis crónica tipo (1,2) A .…”

Section: Introductionunclassified

“…La gastritis atrófica tipo A está se relaciona frecuentemente con otros tipos de enfermedades autoinmunes como la tiroiditis autoinmune, diabetes mellitus tipo I, enfermedad de Addison y el (1)(2)(3) vitíligo . Los pacientes con patologías auto inmunitarias de la tiroides tienen un riesgo aumentado de padecer anemia perniciosa con respecto a la población general.…”

Section: Introductionunclassified

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Autoimmune thyrogastric syndrome in a young woman

Duré¹,

Rotela

2022

Rev. virtual Soc. Parag. Med. Int

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El síndrome tirogástrico autoinmune es la asociación entre dos patologías de origen autoinmune: la anemia perniciosa y la tiroiditis autoinmune, generalmente de presentación en adultos mayores.Se presenta caso de una mujer de 34 años que acude por derrame pericárdico asociado a una pancitopenia por déficit de vitamina B12 debida a una gastritis atrófica de origen autoinmunitaria. Se diagnostica una tiroiditis autoinmune. Recibe tratamiento con complejo B y levotiroxina, con mejoría del derrame.Es importante que ante patologías autoinmunitarias se realice la búsqueda sistemática de otras enfermedades de la misma estirpe para el mejor manejo clínico.Palabras claves: síndrome tirogástrico autoinmune, anemia perniciosa, tiroiditis autoinmune.

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