Anémies sévères du post-partum immédiat. Pratique clinique et intérêt du fer par voie intraveineuse

Broche, D.-E.; Armand-Branger, S.; Grangeasse, L.; Terzibachian, J.-J.

doi:10.1016/j.gyobfe.2004.05.014

Cited by 24 publications

(6 citation statements)

References 7 publications

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“…In contrast, in two more recent studies, intravenous iron sucrose was shown to be superior to oral iron for treating anaemic puerperae [22,23]. However, Bhandal et al [22] gave iron only to those patients with proven iron deficiency as a cause of their anaemia, whereas Breyman et al [21] excluded those with prepartum anaemia. These results suggest that oral and intravenous iron appear to be largely equivalent except perhaps in particular circumstances, whereas additional treatment with rHuEPO should be reserved for those patients with profound postpartum inflammation (e.g.…”

Section: Pregnancy and Postpartummentioning

confidence: 98%

“…Regarding the treatment of postpartum anaemia, Breymann et al [21] randomized 40 patients with postpartum anaemia (Hb = 86 ± 11 g/l) to receive iron sucrose or oral iron alone, daily for 4 days beginning 48-72 h postpartum, and found that both regimens were of equal efficacy in both rate and degree of Hb recovery in the postpartum period. In contrast, in two more recent studies, intravenous iron sucrose was shown to be superior to oral iron for treating anaemic puerperae [22,23]. However, Bhandal et al [22] gave iron only to those patients with proven iron deficiency as a cause of their anaemia, whereas Breyman et al [21] excluded those with prepartum anaemia.…”

Section: Pregnancy and Postpartummentioning

confidence: 98%

“…[21] randomized 40 patients with postpartum anaemia (Hb = 86 ± 11 g/l) to receive iron sucrose or oral iron alone, daily for 4 days beginning 48–72 h postpartum, and found that both regimens were of equal efficacy in both rate and degree of Hb recovery in the postpartum period. In contrast, in two more recent studies, intravenous iron sucrose was shown to be superior to oral iron for treating anaemic puerperae [22,23]. However, Bhandal et al .…”

Section: Intravenous Iron Therapy In Non‐surgical Patientsmentioning

confidence: 99%

“…However, Bhandal et al . [22] gave iron only to those patients with proven iron deficiency as a cause of their anaemia, whereas Breyman et al . [21] excluded those with prepartum anaemia.…”

Section: Intravenous Iron Therapy In Non‐surgical Patientsmentioning

confidence: 99%

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Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion

et al. 2007

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Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion Muñoz, M; Breymann, C; García-Erce, J A; Gómez-Ramírez, S; Comin, J; Bisbe, E Muñoz, M; Breymann, C; García-Erce, J A; Gómez-Ramírez, S; Comin, J; Bisbe, E (2008 Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion Abstract Anaemia is a common condition among patients admitted to hospital medicosurgical departments, as well as in critically ill patients. Anaemia is more frequently due to absolute iron deficiency (e.g. chronic blood loss) or functional iron deficiency (e.g. chronic inflammatory states), with other causes being less frequent. In addition, preoperative anaemia is one of the major predictive factors for perioperative blood transfusion. In surgical patients, postoperative anaemia is mainly caused by perioperative blood loss, and it might be aggravated by inflammation-induced inhibition of erythropoietin and functional iron deficiency (a condition that cannot be corrected by the administration of oral iron). All these mechanisms may be involved in the anaemia of the critically ill. Intravenous iron administration seems to be safe, as very few severe side-effects were observed, and may result in hastened recovery from anaemia and lower transfusion requirements. However, it is noteworthy that many of the recommendations given for intravenous iron treatment are not supported by a high level of evidence and this must be borne in mind when making decisions regarding its application to a particular patient. Nonetheless, this also indicates the need for further large, randomized controlled trials on the safety and efficacy of intravenous iron for the treatment of anaemia in different clinical settings. Department of Internal Medicine, University Hospital Virgen de la Victoria, Málaga. Spain. 5Department of Cardiology, Hospital Mar-Esperanza, Barcelona, Spain. 6Department of Anaesthesiology, Hospital Mar-Esperanza, Barcelona, Spain. Correspondence:Prof. Manuel Muñoz.AWGE. AbstractAnaemia is common in medical, surgical and critically ill patients, mostly due to absolute or functional iron deficiency (e.g.chronic blood loss or chronic inflammatory states respectively). Other causes are less frequent. Its presence is predictive for perioperative blood transfusion. Postoperative anaemia is mainly caused by blood loss, and may be aggravated by inflammation-induced inhibition of erythropoietin and functional iron deficiency (not correctable by the administration of oral iron). All these mechanisms may be involved in the anaemia of the critically ill. Intravenous iron administration seems to be safe, with few severe side-effects, and may hasten recovery from anaemia and reduce transfusion requirements. All the same, many indications given for IV iron are not supported by much evidence, which must be borne in mind when making decisions for a particular patient. Thus we need large, randomized controlled trials on the safety and efficacy of IV iron for the trea...

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Section: Pregnancy and Postpartummentioning

confidence: 98%

Section: Pregnancy and Postpartummentioning

confidence: 98%

Section: Intravenous Iron Therapy In Non‐surgical Patientsmentioning

confidence: 99%

“…However, Bhandal et al . [22] gave iron only to those patients with proven iron deficiency as a cause of their anaemia, whereas Breyman et al . [21] excluded those with prepartum anaemia.…”

Section: Intravenous Iron Therapy In Non‐surgical Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion

et al. 2007

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“…In a retrospective study by Broche (2004), administration of intravenous (i.v.) iron reduced the number of transfused puerperal women by 65% . However, there are no published randomized controlled trials comparing i.v.…”

Section: Introductionmentioning

confidence: 99%

Single‐dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study

et al. 2016

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Background and Objectives There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion or intravenous iron, and to describe patient-reported outcomes, and haematological and iron parameters. Materials and MethodsWomen with a postpartum haemorrhage exceeding 1000 ml and an Hb between 5Á6 and 8Á1 g/dl were randomized to 1500 mg of intravenous iron (n = 7) isomaltoside or RBC transfusion (n = 6). Participants completed the Multidimensional Fatigue Inventory and Edinburgh Postnatal Depression Scale, and blood samples were drawn at inclusion, daily during the first week and at weeks 3, 8 and 12.Results We screened 162 women and included 13 (8%). There was no significant difference between groups in fatigue or depression scores. RBC transfusion was associated with a higher Hb on day 1, inhibition of reticulocytosis during the first week and low iron levels. Intravenous iron was associated with increased reticulocytosis during the first week, repleted iron stores and a higher Hb in weeks 3-12.Conclusion This pilot study shows that intravenous iron could be an attractive alternative to RBC transfusion in severe postpartum anaemia, and that a larger trial is needed and feasible.

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Transfusion Alternatives in Obstetrics

Breymann¹

2010

Alternatives to Blood Transfusion in Transfusion Medicine

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Anémies sévères du post-partum immédiat. Pratique clinique et intérêt du fer par voie intraveineuse

Cited by 24 publications

References 7 publications

Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion

Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion

Single‐dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study

Transfusion Alternatives in Obstetrics

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