2023
DOI: 10.1002/bab.2504
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Anemonin inhibits sepsis‐induced acute kidney injury via mitigating inflammation and oxidative stress

Dan Liu,
Li Li,
Zengyan Li

Abstract: Elevated inflammation and oxidative stress (OS) are the main pathologic features of acute kidney injury (AKI)‐caused by sepsis. Here, we made an investigation into the protective effects of the natural compound Anemonin (ANE) on sepsis‐induced AKI both in vitro and in vivo. Lipopolysaccharide (LPS) was applied to construct an in vitro AKI model in renal tubular epithelial cells, and the septic C57BL/6J mouse model was constructed via cecal ligation and puncture (CLP). Cell viability and apoptosis were detected… Show more

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