Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis

He, Xing Xiang; Tang, Jun; Huang, Yan; Wang, Jiaoxue; Li, Haiqing; Duan, Xiaowei; Yu, Sen-Yuan; Hou, Xi-Lu; Liao, Guobin; Liu, Wei

doi:10.18632/aging.203751

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…It should be noted that a combination of 5-FU and anemoside B4 was found to be more efficient in suppressing tumor growth (derived from chemotherapy-resistant HCT116 colorectal cell line) than 5-FU given alone (He et al 2021b). This study provides additional experimental data supporting the potential of triterpene saponins as adjuvants in chemotherapy.…”

Section: Triterpene Saponins Active In In Vivo Models Of Breast Cancermentioning

confidence: 61%

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

et al. 2022

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Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial flora, especially higher plants, they can also be found in some marine organisms. Cytotoxic activity is one of the most frequently reported from a wide array of pharmacological activities known for these metabolites. The current review is an update of our previous paper—Saponins as cytotoxic agents (Podolak et al. Phytochem Rev 9:425–474, 2010), and covers studies that were since published (2010–2021). This part refers to triterpene saponins and complements the first, which was devoted solely to steroidal saponins (Sobolewska et al. Phytochem Rev 19:139–189, 2020). Cytotoxic activities in vitro and in vivo are presented with a main focus on structure-activity relationships and molecular mechanisms of action.

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Section: Triterpene Saponins Active In In Vivo Models Of Breast Cancermentioning

confidence: 61%

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

et al. 2022

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“…Li [32] found that the expression of P-gp protein (drug resistance protein) decreased after treatment with non-toxic dose of AB4, which could reverse the drug resistance of human colon cancer L-OHP resistant cells LoVo / L-OHP. He [33] also found that AB4 inhibited the proliferation of human colon cancer HCT116/5-FU cells in vitro and promoted the apoptosis of mouse drug-resistant colorectal cancer cells HCT11/5-FU in vivo. In addition, the combined treatment of AB4 and 5-FU induced the apoptosis of colorectal cancer cells by phosphorylation of Scr protein kinase and activation of caspase-9.…”

Section: Antitumor Mechanisms Of Ab4mentioning

confidence: 95%

Research progress on pharmacological actions and molecular mechanisms of Anemoside B4

Lü

Wang

et al. 2022

Preprint

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Anemoside B4 (AB4), as an important ingredient of Chinese herb Pulsatilla Chinensis, has been used in Chinese ancient medicine for thousands of years with exact therapeutic effects of anti-inflammation and anti-tumor. Due to its high potency and low toxicity, AB4 has caused more and more attention of researchers. In this paper, we will first review the clinical usage and fundamental research of AB4 against damaging inflammation of liver, lung, kidney, intestine and joints. Then, we will overview its application and molecular mechanisms in a range of cancers, such as liver cancer, lung cancer, colorectal cancer and cervical cancer. In addition, we pay attention to its pharmacological actions and molecular mechanisms against other diseases, for example, retinal injury, allergic conjunctivitis, pain, vulvovaginal inflammatory disease, acute infectious disease and oral ulcer. Finally, we will discuss the future perspectives of AB4, so as to improve its wide application in clinic.

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Novel Perspectives in the Management of Colorectal Cancer: Mechanistic Investigations Into the Reversal of Drug Resistance via Active Constituents Derived From Herbal Medicine

Zeng,

Wang,

Tao

et al. 2024

Phytotherapy Research

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The high incidence and mortality rate of colorectal cancer have become a significant global health burden. Chemotherapy has been the traditional treatment for colorectal cancer and has demonstrated promising antitumor effects, leading to significant improvements in patient survival. However, the development of chemoresistance poses a major challenge during chemotherapy in colorectal cancer, significantly impeding treatment efficacy and affecting patient prognosis. Despite the development of a variety of novel anticolorectal cancer chemotherapy agents, their effectiveness and side effects vary, possibly due to the complex mechanisms of resistance in colorectal cancer. Abnormal drug metabolism or protein targets are the most direct causes of resistance. Further studies have revealed that these resistance mechanisms involve biochemical processes such as altered protein expression, autophagy, and epithelial–mesenchymal transitions. Herbal active ingredients offer an alternative treatment option and have shown promise in reversing colorectal cancer drug resistance. This paper aims to summarize the role of various biochemical processes and key protein targets in the occurrence and maintenance of resistance mechanisms in colorectal cancer. Additionally, it elaborates on the mechanisms of action of herbal active ingredients in reversing colorectal cancer drug resistance. The article also discusses the limitations and opportunities in developing novel anticolorectal cancer drugs based on herbal medicine.

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Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis

Cited by 5 publications

References 31 publications

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

Research progress on pharmacological actions and molecular mechanisms of Anemoside B4

Novel Perspectives in the Management of Colorectal Cancer: Mechanistic Investigations Into the Reversal of Drug Resistance via Active Constituents Derived From Herbal Medicine

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