Anesthesia and developing brain: What have we learned from recent studies

Niu, Yixuan; Jia, Yan; Jiang, Hong

doi:10.3389/fnmol.2022.1017578

Cited by 11 publications

(10 citation statements)

References 78 publications

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“…Autophagy is a double-edged sword, with some studies showing that autophagy causes neurotoxicity, while others confirm its neuroprotective effects. The specific effects of autophagy need to be further investigated ( 34 ). Other mechanisms include oxidative stress and iron death ( 34 ), which are not represented in the basic research hotspot analysis map, probably due to their low number of studies at present.…”

Section: Discussionmentioning

confidence: 99%

“…The specific effects of autophagy need to be further investigated ( 34 ). Other mechanisms include oxidative stress and iron death ( 34 ), which are not represented in the basic research hotspot analysis map, probably due to their low number of studies at present. For specific signaling pathways, Jiaojiao Wang et al have reviewed the current signaling pathways for postoperative neurotoxicity in neonates due to general anesthesia, such as HIPK2/Akt/mTOR, PI3K/Akt, and JAK/STAT, with a view to providing an important reference for the treatment of clinical disease ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

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A bibliometric analysis of the neurotoxicity of anesthesia in the developing brain from 2002 to 2021

et al. 2023

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BackgroundThe neurotoxicity effects of anesthetic exposure on the developing brain have been one of the current research hotspots and numerous articles were published in the past decades. However, the quality and comparative information of these articles have not been reported. This research aimed to provide a comprehensive overview of the current state of the field by investigating research hotspots and publication trends concerning the neurotoxicity of anesthesia in the developing brain.Materials and methodsOn 15 June 2022, we searched articles on the neurotoxicity of anesthesia in the developing brain through the Science Citation Index databases from 2002 to 2021. Data of the author, title, publication, funding agency, date of publication, abstract, type of literature, country, journal, keywords, number of citations, and research direction were collected for further analysis.ResultsWe searched and analyzed 414 articles in English on the field of neurotoxicity of anesthesia in the developing brain from 2002 to 2021. The country with the largest number of publications was The United States (US) (n = 226), which also had the largest total number of citations (10,419). Research in this field reached a small peak in 2017. Furthermore, the largest number of articles were published in three journals, Anesthesiology, Anesthesia and Analgesia, and Pediatric Anesthesia. The top 20 articles that were cited most often were studied. In addition, the top hotspots of this area in clinical investigations and basic research were analyzed separately.ConclusionThis study provided an overview of the development in the neurotoxicity of anesthesia in the developing brain using bibliometric analysis. Current clinical studies in this area were mainly retrospective; in the future, we should place more emphasis on prospective, multicenter, long-term monitoring clinical studies. More basic research was also needed on the mechanisms of neurotoxicity of anesthesia in the developing brain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the neurotoxicity of anesthesia in the developing brain from 2002 to 2021

et al. 2023

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“…There is also more interest as of late due to some concern that certain inhaled and intravenous (i.v.) anaesthetic medications may have negative neurocognitive effects [10 ▪▪ ]. We will discuss a few regional techniques that are gaining popularity in paediatrics for postoperative pain management, including fascial plane blocks, spinal anaesthesia and continuous epidural anaesthesia.…”

Section: Paediatric Regional Anaesthesiamentioning

confidence: 99%

Paediatric pain management: from regional to virtual

Heydinger

Karthic

Olbrecht

2023

Current Opinion in Anaesthesiology

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Purpose of reviewDue to increased interest in opioid-sparing multimodal analgesic strategies both inside and outside of the operating room, anaesthesiologists have started to look towards regional anaesthesia as well as nonpharmacological pain-reducing techniques. The purpose of this article is to discuss current trends and recent developments in regional anaesthesia and virtual reality for paediatric pain management.Recent findingsThe development of novel fascial plane blocks has expanded regional options for anaesthesiologists, especially when neuraxial anaesthesia is not a viable or straightforward option. Other regional techniques, such as spinal anaesthesia and continuous epidural analgesia for infants and neonates, are becoming more popular, as more paediatric anaesthesiologists become familiar with these techniques. Virtual reality for paediatric pain management is a relatively new area of study that has shown promise, but more research needs to be done before widespread adoption of this practice becomes a reality. Various preexisting pain-reducing strategies such as distraction and biofeedback are being integrated with virtual reality to help optimize its effect on pain and anxiety for paediatric patients.SummaryRegional anaesthesia and virtual reality are valuable tools that serve to alleviate pain in paediatric patients. Advances are being made within both fields in various healthcare settings for different types of pain. Over the next few years, they will likely both play an increasing role in paediatric pain management.

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“…Retrospective clinical trials have conflicting results; while some trials found anesthesia related awareness or behavioral abnormalities, the others didn't show such effect. [3,4] Even though there are conflicting results in clinical research about anesthesia-induced neurotoxicity is a big concern for pediatric anesthetists. Besides children, experimental studies also showed that anesthesia could be related with postoperative delirium and neurocognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The bibliometric analysis of most cited 100 papers in anesthesia-induced neurotoxicity

Ocmen,

Erdost,

Hanci

2023

Medicine

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Anesthesia-induced neurotoxicity is a major concern for anesthetists for more than 20 years. Many experimental and clinical studies have been conducted on this topic since late 1990s. However, bibliometric analysis of these papers has not been reported. In this study, we aimed to analyze the 100 most cited articles on anesthesia-induced neurotoxicity. It was planned as cross-sectional study. On January 30, 2023, we searched the “Web of Science (WOS)” database for anesthesia-induced neurotoxicity and most cited 100 papers about this topic were obtained. Data such as authors’ names, year of publication, name of the journal, type of paper, and citation numbers were analyzed. The most cited 100 papers were read by the investigators, and the anesthetic, animal type in experimental studies, any protective agent and the method for detecting neurotoxicity used in the studies were also noted. There were 75 articles and 22 reviews in the 100 most cited articles. We found that most of the papers in most cited 100 list were published between 2010 to 1024. Most of the papers (11%) were from Harvard University and almost half of the papers (49%) were published in Anesthesiology. A great number of studies were performed in newborns or early childhood (85.5%) and inhalational anesthetics (54.7%) were the most studied anesthetic type. Most of the most cited 100 papers were published in Q1 journals (P = .012) and the continent of the most journals in this list was America (P = .014). The median total and annual citation numbers of funded papers were statistically significantly higher (P < .001 and P < .001 respectively). Anesthesia-induced neurotoxicity is very important, especially for pediatric anesthetists. This study is the first to conduct a bibliometric analysis of the most cited 100 publications on this field. Although there was a gap in the publications about this topic during COVID-19 pandemic, we believe that there will be many more publications on anesthesia-induced neurotoxicity since the mechanism, outcome and possible protection are still unknown.

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Anesthesia and developing brain: What have we learned from recent studies

Cited by 11 publications

References 78 publications

A bibliometric analysis of the neurotoxicity of anesthesia in the developing brain from 2002 to 2021

A bibliometric analysis of the neurotoxicity of anesthesia in the developing brain from 2002 to 2021

Paediatric pain management: from regional to virtual

The bibliometric analysis of most cited 100 papers in anesthesia-induced neurotoxicity

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