“…However, the use of anaesthesia also results in a depression of compensatory mechanisms and may, depending upon the nature of the anaesthetic, actually increase the magnitude of a haemodynamic response compared to the same conscious animal model. As another consideration, parenteral dosing is normally required in anaesthetized models due to inhibition of peristaltic activity in the gastrointestinal system by most anaesthetic agents (Ng and Smith 2002;Torjman et al 2005). First, the response obtained under anaesthesia may differ from the target clinical population typically composed of conscious individuals (see Fig.…”