Anesthésie pour chirurgie d'un phéochromocytome malin. Accès hypertensif après administration de dropéridol

Brinquin, L.; Philip, Y.; Gulluche, Y. Le; Jp, Bonsignour; Buffat, J

doi:10.1016/s0750-7658(87)80080-1

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…In any step of their catabolism, circulating phenolic metabolites can undergo phase II metabolism in the liver, leading to the formation of sulfate, glucuronide, and methylated conjugates through the action of sulfotransferases (SULTs), uridine-5′-diphosphate glucuronosyltransferases (UGTs), and catechol-O-methyltransferases (COMTs), respectively. 40 It is however still not fully understood if phase II conjugates can still be catabolized into smaller metabolites or if they are directly excreted in the urine without further modifications. Moreover, since both endogenous human and microbiota metabolism play important roles in producing lowmolecular weight phenolic compounds in blood circulation, it is difficult to unravel the origin of one compound.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Carregosa

Carecho

Figueira

et al. 2019

J. Agric. Food Chem.

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Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)phenols is very low when compared with their corresponding (poly)phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)phenolic metabolites effects, range from 0.1 to <50 μM and their role on neuroinflammation, a central hallmark in neurodegenerative diseases.

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Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Carregosa

Carecho

Figueira

et al. 2019

J. Agric. Food Chem.

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“…Histamin (und Glukagon) wurden in der Vergangenheit als Provokationstest bei Verdacht auf Phäochromozytom eingesetzt (13,21); neben der Katecholaminausschüttung führt Histamin zu weiteren eigenständigen und unerwünschten Kreislaufeffekten (3). Zeitgleich mit der Injektion von Droperidol aufgetretene Blutdruckkrisen wurden zunächst als Fallbericht mitgeteilt (4.9, andere Autqen wiesen eine Verdoppelung der Noradrenalinspiegel nach Injektion von Droperidol nach (7). Dieses Phänomen blieb zunächst unverständlich, da Droperidol zu einer kurzfristigen U-Blockade mit Abfall des Blutdrucks fuhrt (19).…”

Section: Prämedikation Anästhesie Postoperative Phaseunclassified

Anästhesie bei Patienten mit Phäochromozytom - Eigene Ergebnisse und Übersicht

Adams¹,

Hempelmann²

1993

Anästhesiol Intensivmed Notfallmed Schmerzther

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Phaeochromocytoma is a rare, autonomous catecholamine secreting tumour of the sympatho-adrenergic system. Due to the continuous or phasic secretion of catecholamines from the tumour, patients present with hypertensive crisis, episodic or sustained hypertension or arrhythmia. Excessive intraoperative hypertension unable to control by usual methods should be considered to be a phaeochromocytoma. Surgical removal of identified lesions should be performed under controlled conditions and after sufficient preparation of the patient. Preoperative alpha-adrenergic blockade with prazosin and phentolamine allows an increase in intravascular volume and affords some protection against excessive intraoperative hypertension. The use of beta-adrenergic antagonists is only recommended in patients with arrhythmia (especially tachycardia) and after induction of alpha-adrenergic blockade. For operation of phaeochromocytoma, modified neuroleptic anaesthesia is a useful anaesthetic technique. Intraoperative hypertension is controlled with sodium nitroprusside and phentolamine. Intravascular volume is substituted under CVP or PAP control, and epinephrine or norepinephrine are used if necessary. During the postoperative period, hypotension or hypertension or left ventricular failure may occur. In an own study, 9 patients with phaeochromocytoma were investigated, 7 patients with other operations of the adrenal glands served as controls. Despite specific preoperative preparation and intraoperative use of antihypertensive drugs, excessive increases in blood pressure could not be avoided in some cases. Extremely high plasma levels of catecholamines up to the factor 1,000 of the normal range were found. Even in controls, considerable increases in blood pressure and catecholamine levels were observed.(ABSTRACT TRUNCATED AT 250 WORDS)

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Stratégie simplifiée pour l'anesthésie du phéochromocytome

Colson

Ribstein

1991

Annales Françaises d'Anesthésie et de Réanimation

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Anesthésie pour chirurgie d'un phéochromocytome malin. Accès hypertensif après administration de dropéridol

Cited by 6 publications

References 9 publications

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Anästhesie bei Patienten mit Phäochromozytom - Eigene Ergebnisse und Übersicht

Stratégie simplifiée pour l'anesthésie du phéochromocytome

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