Anesthetic considerations of the herbal, kava

Raduege, Kevin M; Kleshinski, James F; Ryckman, Joseph V.; Tetzlaff, John E.

doi:10.1016/j.jclinane.2003.08.009

Cited by 30 publications

(25 citation statements)

References 44 publications

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“…Kava may also produce adverse neurologic effects (possibly related to its dopaminergic antagonism) 77,78 that may cause excessive perioperative sedation. 79 The pharmacokinetic and pharmacodynamic aspects of such interactions with this plant have not been studied systematically. However, pharmacodynamic herbdrug interactions include potentiation of the sedative effect of anesthetics by kava.…”

Section: T1mentioning

confidence: 99%

Drug Interactions With Herbal Medicines

Skalli¹,

Zaîd²,

Soulaymani-Bencheikh³

2007

Therapeutic Drug Monitoring

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Section: T1mentioning

confidence: 99%

Drug Interactions With Herbal Medicines

Skalli¹,

Zaîd²,

Soulaymani-Bencheikh³

2007

Therapeutic Drug Monitoring

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“…Kava prolongs anesthesia time, causes perioperative hypotension, increases drowsiness with narcotic administration, and has hepatotoxic side effects [21]. St. John’s wort is associated with hypotension under general anesthesia and has been linked to serotonin syndrome when used in combination with selective serotonin reuptake inhibitors [22].…”

Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine (CAM) use in women with pelvic floor disorders: a cohort study

et al. 2009

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Introduction and hypothesis The objective of this study was to compare complementary and alternative medicine (CAM) use in women with and without pelvic floor disorders (PFD). Methods We conducted a survey of women presenting to a specialty urogynecology (Urogyn) and gynecology (Gyn) clinic that examined demographic data, CAM use, and the presence of PFD (validated questionnaires). T tests, Fisher’s exact tests, and logistic regression were used for analysis. To detect a 20% difference between groups, 234 Urogyn and 103 Gyn patients were needed. Results Participants included 234 Urogyn and 103 Gyn patients. Urogyn patients reported more CAM use than Gyn patients, even when controlled for differences between groups (51% vs. 32%, adjusted p=0.006). Previous treatment (61% vs. 39%, adjusted p<0.001) and increased number of PFD was associated with increased CAM use (adjusted p=0.02). Conclusions Women with PFD use CAM more frequently than women without PFD.

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“…In order to use micellar carriers containing kavain as local anaesthetic (12), the influence of physiological solutes (NaCl 0.9% m/v and glucose 10% m/v) on kavain apparent solubility was investigated in the case of SDS micellar systems, those having the best characteristics in solubilizing kavain. Our studies evidenced that the solubility of kavain is not significantly affected till to 200 mM SDS micellar solutions.…”

Section: Effects Of Physiological Solutes On Kavain Solubility In Sdsmentioning

confidence: 99%

“…(kava-kava), a tropical plant growing in the South Pacific Islands (10) and traditionally used for its soporific and narcotic effects (10,11). Kava-kava extracts or isolated kavalactones are nowadays used for the treatment of anxiety and improvement of stress disorders, nervous tension and restlessness (10) and recently, a local anaesthetic activity has also been reported (10)(11)(12). Thus, in view of a possible therapeutic use of kava-kava extracts or single constituents for local anaesthesia, the behaviour of kavain, tested as a model-molecule, in the presence of micellar carrier systems, relatively unexpensive and simple formulation to topical application, was investigated in order to improve its scarce water solubility.…”

Section: Introductionmentioning

confidence: 99%