Anesthetic Effect of Intrauterine Lidocaine Plus Naproxen Sodium in Endometrial Biopsy

Dogan, Erbil; Celıloğlu, Murat; Sarihan, Elif Irem; Demir, Ahmet

doi:10.1097/01.aog.0000109519.74229.30

Cited by 59 publications

(71 citation statements)

References 11 publications

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“…The largest trial of NSAIDs prior to IUD insertion used ibuprofen 400 mg, a dose lower than is commonly recommended in the United States [7]. Interestingly, NSAIDs are often recommended prior to other office-based gynecologic procedures, such as colposcopy [8], endometrial biopsy [9] and dilation and curettage [10][11][12], though data are mixed about their effectiveness with these procedures as well.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

et al. 2015

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TitleProphylactic ibuprofen does not improve pain with IUD insertion: a randomized trial. AbstractObjective: To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design: We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion.Results: A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions: Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

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Section: Introductionmentioning

confidence: 99%

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

et al. 2015

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“…Dogan et al conducted a study in which 120 women became candidate of outpatient endometrial biopsy and assigned to four Local Anesthesia Methods in Outpatient Endometrial Biopsy groups; a group received 5cc of intrauterine 2% lidocaine, and the other three received 550mg oral naproxen, 5cc of intrauterine lidocaine and 550 mg oral naproxen plus intrauterine normal saline. They concluded that intrauterine lidocaine instillation significantly decreases pain of pipelle endometrial when used in combination with oral naproxen sodium; while there was not seen considerable difference in two groups which received lidocaine and naproxen with controlling group (13). As it is declared, the results of different researches in this field were not aligned necessarily.…”

Section: Discussionmentioning

confidence: 98%

Role of Local Anesthetics on Pain Relief in Endometrial Biopsy: Randomized Clinical Trial

Ouladsahebmadarek¹,

Parvin²,

Fatemeh³

et al. 2014

IJWHR

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Objectives: Endometrial biopsy is necessary for diagnosing the reason of abnormal uterine bleeding in perimenopausal women. Currently outpatient endometrial biopsy is used for evaluation of abnormal uterine bleeding which is associated with moderate to severe pain. Using lidocaine is one of the procedures which is used for pain relief while biopsy. This study is aimed at comparing the effect of different local anesthesia procedures on pain relief during endometrial biopsy. Materials and Methods: In this randomized clinical trial, 160 multiparous 40-55 years old women with AUB (Abnormal Uterine Bleeding), candidates for endometrial biopsy, were randomly assigned into four equal groups, to receive: 1-intrauterine lidocaine; 2-cervical spray lidocaine; 3-intrauterine lidocaine plus cervical spray lidocaine; or 4-intrauterine distilled water. Pain relief was measured at 3 different times: during endometrial biopsy, just after and 15 minutes after biopsy. Results: Pain intensity was reduced significantly at different times in intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine receivers in compare with the groups which received cervical spray lidocaine and distilled water. The mean of difference pain relief during biopsy and 15 minutes after that was reduced significantly in the group which received intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine in comparison with the other two groups. Conclusion: Intrauterine lidocaine was effective during endometrial biopsy, and using it with cervical spray lidocaine had no more beneficial effect.

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“…[12] In another placebocontrolled trial, Dogan et al showed that naproxen when combined with lidocaine was effective in relieving pain during endometrial biopsy. [13] Drotaverine is effectively used in gynecological conditions like dysmenorrhea and nongynecological conditions like renal colic and cholelithiasis. [8] In the studies by Sharma et al and Singh et al, drotaverine when used during labor was shown to accelerate the labor and no adverse effects were seen.…”

Section: Discussionmentioning

confidence: 99%

“…[9,10] In literature there are studies where plain NSAIDs were used for pain relief before minor gynecological procedures and compared with placebo, paracervical block, intrauterine lignocaine insertion, local spray of lignocaine gel, but the results were not conclusive. [12][13][14] Various reasons have been cited for this, like cultural factors for pain tolerance, race, diameter of the hysteroscope, etc. There is a paucity of similar studies on Indian women.…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy

Sharma¹,

Aruna²,

Kumar³

et al. 2009

Indian J Med Sci

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Anesthetic Effect of Intrauterine Lidocaine Plus Naproxen Sodium in Endometrial Biopsy

Abstract: I

Cited by 59 publications

References 11 publications

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

Role of Local Anesthetics on Pain Relief in Endometrial Biopsy: Randomized Clinical Trial

Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy

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