Anesthetic implications in a child with Crouzon syndrome

Kumar, Ajeet; Goel, Nitika; Sinha, Chandni; Singh, Abhishek

doi:10.4103/0259-1162.200234

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…CS patients should receive orthodontic evaluations at a young age. Early treatment allows obtaining higher possibilities to correct dental issues and facial asymmetry and prevent further complications such as increased intracranial pressure, respiratory distress, and optic atrophy [ 7 ]. Surgical extraction of several permanent teeth could reduce the crowding in the dental arch and the use of orthodontic appliances could expand the maxilla [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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An Adult Case of Crouzon Syndrome: Diagnostic Features and Treatment Modalities

Sobouti,

Dadgar,

Salehabadi

et al. 2024

Cureus

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Craniosynostosis syndromes are birth defects characterized by the premature fusion of one or more cranial sutures before the completion of brain growth and development. Crouzon syndrome (CS) is the most common craniosynostosis condition. The CS manifestations result from the early fusion of superior and posterior sutures of the maxilla along the orbital wall and affect the cranial vault, base, orbital, and maxillary regions. This report presents a rare case of a 25-year-old male CS patient referred for orthodontic treatment with the chief complaint of severe irregularities in the arrangement of teeth and abnormal facial appearance. In this report, the clinical, cephalometric features, and initial orthodontic management of this patient are discussed as part of multidisciplinary management.

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Section: Discussionmentioning

confidence: 99%

“…These characteristics either become more prominent or regress through time. Hearing loss is prevalent (55%), and C2 and C3 spinal fusion occur at a rate of 30% [ 7 ]. Progressive hydrocephalus (30%), tonsillar herniation, and sacrococcygeal tail are some of the other symptoms.…”

Section: Introductionmentioning

confidence: 99%

An Adult Case of Crouzon Syndrome: Diagnostic Features and Treatment Modalities

Sobouti,

Dadgar,

Salehabadi

et al. 2024

Cureus

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“…More than half of the known human pathological variants of genetic diseases are caused by point mutations. The Crouzon syndrome, recognized by Craniosynostosis, is an autosomal dominant genetic disease that causes premature fusion of the cranial sutures and malformations of the skull in infants (480)(481)(482). Crouzon syndrome is caused by a missense mutation, that is heterozygous and is present in the fibroblast growth factor receptor 2 (FGFR2) gene, chromosome 10q25-26, on exon 9 at cysteine 342, also known as FGFR2C³⁴²Y⁄ ⁺ (483,484).…”

Section: Case Study: Use Of Cas9 To Cure Crouzon Syndrome and Heredit...mentioning

confidence: 99%

Microbial treasure trove : Unravelling the potential of class 2 CRISPR–Cas systems

Mohanraju¹

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General introduction and thesis outline 1Prokaryotes versus viruses PRoKaRyotes veRsus viRusesL ife on earth is comprised of three domains; the Bacteria, the Archaea, and the Eukarya. Survival of all forms of life is continuously confronted by their constantly changing surroundings. Prokaryotes (bacteria and archaea) dominate many natural habitats, including some highly competitive and harsh environments. They thrive in such environments despite facing a constant threat of invasions by selfish Mobile Genetic Elements (MGEs) such as transposons, plasmids and viruses. Bacteriophages (phages), are the viruses of bacteria that have been estimated to be the most abundant biological entities on the planet with population numbers in the order of 10³¹ (1, 2). Phages are divided into two groups, virulent and temperate. Virulent phages follow a strictly productive lytic life cycle for propagation which ultimately kills the host for the release of new viral particles, each of which can engage in another round of infection. Temperate phages have the choice to switch between productive and dormant states. They either multiply in their host cells leading to cell lysis similar to virulent phages or integrate their phage genome into the bacterial chromosome to become a 'dormant' prophage. Prophages are propagated passively by the replication machinery of the bacterial cell (3). Microscopic phage-bacteria interactions have quite a profound effect on the macroscopic scale as they strongly influence global biogeochemical cycles (4), global climate (5), incidence of human diseases ( 6), as well as patterns of microbial genome diversity (7).The Red Queen hypothesis (Box 1) posits that antagonistic biotic interactions, such as those displayed by hosts and parasites, generates a selective pressure on host organisms to continuously evolve systems that neutralize infections leading to adaptations of the host and counteradaptations on the parasite's end (8). The continuous arms race of developing infection and resistance strategies results in a rapid co-evolution of the parasite's offence systems and host defence systems. Such an evolutionary trend is extremely prominent in phage-microbe interactions. This is mainly due to the rapid evolution and turnover of phage particles (4) leading to acute selective pressure on microbial communities to evade infection by developing immunity.

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Managing the Difficult Airway in a Neonate

Blythe

Cusack

2020

Emerging Topics and Controversies in Neonatology

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Anesthetic implications in a child with Crouzon syndrome

Cited by 10 publications

References 7 publications

An Adult Case of Crouzon Syndrome: Diagnostic Features and Treatment Modalities

An Adult Case of Crouzon Syndrome: Diagnostic Features and Treatment Modalities

Microbial treasure trove : Unravelling the potential of class 2 CRISPR–Cas systems

Managing the Difficult Airway in a Neonate

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