Anesthetic Implications of Protein C Deficiency

Rc, Wetzel; Br, Marsh; Yaster, Myron; Jf, Casella

doi:10.1213/00000539-198609000-00013

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Cited by 7 publications

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“…Protein C inhibits the coagulation cascade by inactivating factors Va and VIIIa 4 and accelerates clot lysis, whilst protein S, the cofactor of protein C, enhances this property of anticoagulation 5 . A physiological decrease in total and free protein S is seen in pregnancy and the post partum period, predisposing to venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic Management of the Parturient with Protein S Deficiency and Lumboperitoneal Shunt

Gupta

Prakash

Gujral

2003

Anaesth Intensive Care

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Protein S, a vitamin K-dependent plasma protein, is a cofactor for protein C, an essential component of the regulatory system of coagulation. We describe the anaesthetic management of a parturient with protein S deficiency and an indwelling lumboperitoneal shunt, which was placed following transverse and sagittal sinus thrombosis. She was treated with aspirin and enoxaparin during pregnancy and underwent caesarean section under general anaesthesia without complication.

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Section: Discussionmentioning

confidence: 99%